A mild halogenation of pyrazoles using sodium halide salts and Oxone

A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided.     

What causes the hyperintense T2-weighting and increased short T2 signal in the corticospinal tract?

The corticospinal tract (CST) appears hyperintense on both T₂-weighted images and myelin water maps. Here, an extended multiecho T₂ relaxation sequence with echoes out to 1120 ms was used to characterize the longer T₂ times present in the CST. The T₂ distribution from the CST was compared to other white matter structures in 14 healthy subjects. The intra-/extracellular T₂ peak of the CST was broadened relative to other white matter structures and often split into two distinct peaks. In the CST, it appeared that the intracellular and extracellular water environments had unique T₂ times, causing the intracellular water peak to be pushed down into the myelin water T₂ regime and the extracellular peak to be pushed up to longer T₂ times. The conventional myelin water T₂ limits of 5-40 ms resulted in an artificial increase in myelin water fraction (MWF), causing the CST to be bright on myelin water images. When the upper limit for MWF was decreased to 25 ms, the CST regions exhibited MWF values similar to those found for adjacent anterior and posterior regions. The CST has unique magnetic resonance characteristics, which should be taken into consideration when being examined, especially when compared to pathological tissue.     

Optimization of small deviation for mixed fractional Brownian motion with trend

In this paper, we investigate two-sided bounds for the small ball probability of a mixed fractional Brownian motion with a general deterministic trend function, in terms of respective small ball probability of a mixed fractional Brownian motion without trend. To maximize the lower bound, we consider various ways to split the trend function between the components of the mixed fractional Brownian motion for the application of Girsanov theorem, and we show that the optimal split is the solution of a Fredholm integral equation. We find that the upper bound for the probability is also a function of this optimal split. The asymptotic behaviour of the probability as the ball becomes small is analysed for zero trend function and for the particular choice of the upper limiting function.     

In vivo multiecho T2 relaxation measurements using variable TR to decrease scan time

Multiecho T2 relaxation measurements to determine geometric mean T2 (GMT2) and myelin water fraction (MWF) are lengthy, resulting in increased motion artefacts from patient discomfort and reduced patient compliance. The goal of this study was to shorten the acquisition time for multiecho T2 measurements without affecting T1 weighting by varying TR across k-space. Six phantoms and 10 healthy volunteers were imaged with both a constant TR and a variable TR multiecho T2 sequence. T1 weighting was determined by TR at the center of k-space; for variable TR measurement, TR was shortened linearly from the center to the edges of k-space. Phantoms showed excellent agreement for proton density and GMT2 between constant and variable TR measurements. No significant differences were found in proton density or MWF for any of the brain structures between the two measurements. The average GMT2 over all structures between the two experiments was not significantly different. In summary, with the variable TR approach, scan time was reduced by >20%, with minimal loss of image resolution and no significant affect on proton density, MWF or GMT2.     

Transport in 3D volume-preserving flows

Summary The idea of surfaces of locally minimal flux is introduced as a key concept for understanding transport in steady three-dimensional, volume-preserving flows. Particular attention is paid to the role of the skeleton formed by the equilibrium points, selected hyperbolic periodic orbits and cantori and connecting orbits, to which many surfaces of locally minimal flux can be attached. Applications are given to spheromaks (spherical vortices) and eccentric Taylor-Couette Flow.     

Universal behaviour in families of area-preserving maps

We have investigated numerically the behaviour, as a perturbation parameter is varied, of periodic orbits of some reversible area-preserving maps of the plane. Typically, an initially stable periodic orbit loses its stability at some parameter value and gives birth to a stable orbit of twice the period. An infinite sequence of such bifurcations is accomplished in a finite parameter range. This period-doubling sequence has a universal limiting behaviour: the intervals in parameter between successive bifurcations tend to a geometric progression with a ratio of $\text{1}\text{δ}\text{=}\text{1}\text{8.721097200}$…, and when examined in the proper coordinates, the pattern of periodic points reproduces itself, asymptotically, from one bifurcation to the next when the scale is expanded by α = ?4.018076704… in one direction, and by β = 16.363896879… in another. Indeed, the whole map, including its dependence on the parameter, reproduces itself on squaring and rescaling by the three factors α, β and δ above. In the limit we obtain a universal one-parameter, area-preserving map of the plane. The period-doubling sequence is found to be connected with the destruction of closed invariant curves, leading to irregular motion almost everywhere in a neighbourhood.     

Conserved charges and supersymmetry in principal chiral and WZW models

Conserved and commuting charges are investigated in both bosonic and supersymmetric classical chiral models, with and without Wess–Zumino terms. In the bosonic theories, there are conserved currents based on symmetric invariant tensors of the underlying algebra, and the construction of infinitely many commuting charges, with spins equal to the exponents of the algebra modulo its Coxeter number, can be carried out irrespective of the coefficient of the Wess–Zumino term. In the supersymmetric models, a different pattern of conserved quantities emerges, based on antisymmetric invariant tensors. The current algebra is much more complicated than in the bosonic case, and it is analysed in some detail. Two families of commuting charges can be constructed, each with finitely many members whose spins are exactly the exponents of the algebra (with no repetition modulo the Coxeter number). The conserved quantities in the bosonic and supersymmetric theories are only indirectly related, except for the special case of the WZW model and its supersymmetric extension.