Enhanced affinochromism of polydiacetylene monolayer in response to bacteria by incorporating CdS nano-crystallites

By incorporating bio-specific receptors, such as p-10,12-pentacosadiyne-1-N-(3,6,9-trioxaundecylamide)-alpha-D-mannopyranoside (MPDA), into 10,12-pentacosadiyonic acid (PDA) monolayer, the MPDA/PDA monolayer underwent affinochromatic transition in response to the bacteria binding to the receptor. Here, we described a new method to study the membrane/macromolececular interaction between Escherichia coli (E. coli) and mannose and its relative affinochromism by modifying MPDA/PDA with CdS nano-crystallites (MPDA/PDA-CdS). CdS not only triggered the strong tropism of the bacteria but also reduced the rigidity of the MPDA/PDA backbone, resulting in the enhanced affinochromism. This discovery might be of significance in basic biophysical studies of membrane/macromolececular and designing novel biosensor.     

正入射全自动扫描反射率绝对值光谱仪的研制

采用Ｍ型棱镜分光束法研制了一台全自动扫描绝对反射率光谱仪，测量光谱范围为３５０ｎｍ～８２０ｎｍ（１．５～３．５ｅＶ），样品入射角为５°，测量和数据采集处理全过程由计算机控制．测量绝对值精度优于±１％，测量重复性优于０．１％．采用本谱仪对热蒸发金膜和（１１１）锗本征体单晶进行测量，获得了与椭偏测量以及文献报道相一致的结果．     

A Facile Method to Assemble PNIPAM‐Containing Microgel Photonic Crystals

Structural colors: Poly(N‐isopropyl acrylamide) based microgel photonic crystals are fabricated by using a new method called “high‐temperature‐induced hydrophobic assembly”. The assembling conditions affect the water content of the crystals, thus determining their structural color (see image). The obtained photonic crystals are sensitive to solvents, and the reversible changes in their color can be observed with the naked eye.

     

Enantioselective synthesis of β-hydroxyisobutyric acid: a useful synthon in the synthesis of polypropionate-type natural products

The aldol reaction of formaldehyde with the dicyclopentylborinyl enolate derived from $\text{S}$-(or $\text{R}$-) 1-tert-butyldimethylsilyloxy-l-cyclohexylbutan-2-one, followed by desilylation and sodium meta-periodate oxidation, provides $\text{R}$-(or $\text{S}$-) β-hydroxyisobutyric acid.     

Separation of electrical and optical energy gaps for constructing bipolar organic wide bandgap materials

An electrical and optical energy gaps separation strategy is put forward for the design of organic wide bandgap semiconductors. This new principle could achieve optimization of wide bandgap (both high singlet and triplet energies) and favorable carrier injection energy levels simultaneously.     

乙醇法合成硼硅Pentasil型分子筛

七十年代,美国Mobil公司^[1]发表了ZSM-5型沸石分子筛的专利,该沸石具有独特的结构和良好的催化性能,在石油化工技术中业已展现出广阔的应用前景.1980年,M.Taramasso^[2]等人用四丙基胺、正硅酸乙酯等原料合成出了四种硼硅分子筛.1981年,作者^[3]在国内首次用有机胶合成出硼硅Pentasil型分子筛(ZSM-5型).本文以水玻璃、白炭黑为硅源,用乙醇取代有机胺,在微量导向剂存在下,合成了硼硅pentasil型分子筛;并用正交实验的方法探讨了合成中诸因素对分子筛结晶度的影响.     

Hydrothermal Synthesis,Conversion Reaction,and Crystal Structure of 2-D 2-bromo-1,4-benzenedicarboxylate Copper(II) Complex with 2,2′-bipyridine

A fully deprotonated 2-bromo-1,4-benzenedicarboxylate copper(II) complex, [Cu(bbdc)(2,2′-bipy)](H₂O) (bbdc= 2-bromo-1,4-benzenedicarboxylate dianion, 2,2′-bipy=2,2′-bipyridine), was synthesized under hydrothermal conditions. This compound also can be prepared from the partly deprotonated [Cu(Hbbdc)₂(2,2′-bipy)] under basic and hydrothermal conditions. The crystal structure consists of infinite chains of [Cu₂(μ₄-bbdc)]²⁺ building blocks connected by bis-monodentate bbdc ligands and exhibits an extended 2-D architecture. Electronic supplementary material Electronic supplementary material is available for this article at and accessible for authorised users.     

THE OPERATOR METHOD FOR SOLVING THE MOMENT EQUATION OF FOKKER-PLANCK EQUATION

In this paper we study the moment equation of Fokker-Planck equation (FPE) , by using the translation operator and the technique of the exponential operator decomposition. Some results of the relaxation process described by FPE are obtained.     

Consensus model for identification of novel PI3K inhibitors in large chemical library

Phosphoinositide 3-kinases (PI3Ks) inhibitors have treatment potential for cancer, diabetes, cardiovascular disease, chronic inflammation and asthma. A consensus model consisting of three base classifiers (AODE, kNN, and SVM) trained with 1,283 positive compounds (PI3K inhibitors), 16 negative compounds (PI3K non-inhibitors) and 64,078 generated putative negatives was developed for predicting compounds with PI3K inhibitory activity of IC₅₀ ≤ 10 μM. The consensus model has an estimated false positive rate of 0.75%. Nine novel potential inhibitors were identified using the consensus model and several of these contain structural features that are consistent with those found to be important for PI3K inhibitory activities. An advantage of the current model is that it does not require knowledge of 3D structural information of the various PI3K isoforms, which is not readily available for all isoforms.     

Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine

Four prolinamide-based organocatalysts were readily synthesized and applied to the direct asymmetric aldol reactions of ketones and aromatic aldehydes in brine. When 2,4-dinitrophenol (DNP) was used as an acidic additive, 1 mol % low loading of 2b afforded aldol products with excellent diastereoselectivity of up to 98/2 dr and high enantioselectivity of up to 97% ee.