Synthesis,microwave‐promoted catalytic activity in Suzuki–Miyaura cross‐coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group

A mixture of benzimidazole salts (2–7), Pd(OAc)₂ and K₂CO₃ in DMF–H₂O catalyzes the Suzuki–Miyaura cross‐coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki–Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2–7) were identified by ¹H‐¹³C, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X‐ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1–7) were also tested against standard strains. Copyright © 2011 John Wiley & Sons, Ltd.     

Monitoring of Mycophenolic Acid in the Plasma of Transplant Patients by Capillary Electrophoresis

Plasma samples from 60 transplant patients on mycophenolate mofetil therapy were analysed using validated capillary electrophoresis (CE) method to determine mycophenolic acid (MPA) and its main metabolite mycophenolic acid glucuronide. Enzyme multiplied immunoassay technique (EMIT) values were available for the same samples. The differences between the results from the two methods was clarified by using Bland–Altman analysis and further statistical analysis. More than 90% of the results showed a positive bias, with EMIT giving higher levels than CE.     

Radioiodination and preliminary biological tests of aniline-mustard and its glucuronide conjugate as a potential anticancer prodrug

Aniline-mustard and its glucuronide conjugate were radioiodinated with ¹³¹I. The preliminary dynamic tests were carried out on rabbits. The scintigrams showed clearly that the glucuronide conjugate of aniline-mustard was very quickly cleared from the metabolism, accumulating in the bladder in about 15 minutes. The clearance time of radioiodinated aniline-mustard-glucuronide was considerably longer (about 45 min.). The results obtained from the biodistributional studies have represented interesting differences between the metabolic details of radioiodinated compounds, and indicated that the glucuronide conjugate of aniline-mustard may be a promising radioiodinated prodrug, if verification of its selective accumulation in some kinds of tumor cells can be obtained.     

On stable least squares solution to the system of linear inequalities

The system of inequalities is transformed to the least squares problem on the positive ortant. This problem is solved using orthogonal transformations which are memorized as products. Author’s previous paper presented a method where at each step all the coefficients of the system were transformed. This paper describes a method applicable also to large matrices. Like in revised simplex method, in this method an auxiliary matrix is used for the computations. The algorithm is suitable for unstable and degenerate problems primarily.      

On optimal design of rigid plastic beams with additional supports in the case of impulsive loading

A rigid plastic beam under implusive loading is considered. In order to increase the stiffness of the beam, some additional supports are applied. The locations of these supports must be selected so as to minimize the maximal permanent deflection of the beam. This problem is solved with the aid of the optimal control theory of distributed parameter systems. Optimality conditions are deduced. The case where the problem is self-conjugate is examined. An example is given.     

Heat transfer in an oscillating vertical annular liquid column open to atmosphere

The heat transfer from a surface heated with constant heat flux to an oscillating vertical annular liquid column having an interface with the atmosphere is investigated experimentally in the present paper. The analysis is carried out for the case of different oscillation frequencies while the displacement amplitude remains constant. Based on the experimental data a correlation equation is obtained for the cycle-averaged Nusselt number as a function of kinetic Reynolds number.     

Theory of vibronic interactions in D2 and H2: a comparison between multichannel-quantum-defect and coupled-equation approaches

New experimental energy levels for the 2pπC(1)Π(u)(-) state of D(2) are reported extending up to the dissociation limit and including rotational quantum numbers up to N = 10. These data are extracted from recent high resolution optical emission spectra, and they are used for a detailed comparison of two theoretical approaches, both of which are fully ab initio and are based on the same state-of-the-art clamped-nuclei potential energy curves. These are the coupled differential equations (CE) and the multichannel quantum defect theory (MQDT) approaches, each of which accounts for adiabatic corrections and non-adiabatic couplings. Both theoretical approaches reproduce the experimental levels to within a fraction of a wavenumber unit (cm(-1)) for the lower vibrational quantum numbers, with the MQDT surpassing the CE method. As the dissociation limit is approached, the residuals observed-calculated increase up to several cm(-1) and the MQDT method is up to a factor of two less accurate than the CE method. The same analysis is carried out with existing data for the H(2) isotopomer and yields similar results. An analogous comparison is also made for the 3pπD(1)Π(u)(-) and 4pπD('1)Π(u)(-) states for both isotopomers, where the MQDT is found to be superior to the CE approach.     

Prompt Gamma Activation Analysis with the Texas Cold Neutron Source

A Prompt Gamma Activation Analysis (PGAA) facility is being developed at The University of Texas at Austin (UT). The UT-PGAA facility will utilize a focused cold-neutron beam from the Texas Cold Neutron Source (TCNS). the TCNS consists of a cold source cryostat and a curved neutron guide. the use of a guided focused cold-neutron beam will provide a high capture reaction rate and low background. The UT-PGAA facility will be used in the nondestructive determination of B, Cd, Gd and S in biological and environmental samples.