全文获取类型
收费全文 | 3454篇 |
免费 | 136篇 |
国内免费 | 17篇 |
专业分类
化学 | 2160篇 |
晶体学 | 6篇 |
力学 | 133篇 |
数学 | 633篇 |
物理学 | 675篇 |
出版年
2023年 | 34篇 |
2022年 | 98篇 |
2021年 | 135篇 |
2020年 | 78篇 |
2019年 | 93篇 |
2018年 | 69篇 |
2017年 | 52篇 |
2016年 | 125篇 |
2015年 | 120篇 |
2014年 | 129篇 |
2013年 | 198篇 |
2012年 | 246篇 |
2011年 | 280篇 |
2010年 | 155篇 |
2009年 | 118篇 |
2008年 | 236篇 |
2007年 | 210篇 |
2006年 | 191篇 |
2005年 | 199篇 |
2004年 | 146篇 |
2003年 | 115篇 |
2002年 | 117篇 |
2001年 | 54篇 |
2000年 | 47篇 |
1999年 | 34篇 |
1998年 | 18篇 |
1997年 | 35篇 |
1996年 | 27篇 |
1995年 | 28篇 |
1994年 | 25篇 |
1993年 | 17篇 |
1992年 | 14篇 |
1991年 | 6篇 |
1990年 | 11篇 |
1989年 | 12篇 |
1988年 | 9篇 |
1987年 | 4篇 |
1986年 | 9篇 |
1985年 | 13篇 |
1984年 | 19篇 |
1983年 | 12篇 |
1982年 | 5篇 |
1981年 | 10篇 |
1980年 | 11篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1974年 | 5篇 |
1973年 | 3篇 |
排序方式: 共有3607条查询结果,搜索用时 15 毫秒
81.
The influence of simulation methods, cutoff based and particle mesh Ewald (PME) on the accuracy by which experimentally derived nuclear Overhauser effect (NOE) data are reproduced, has been investigated using 500-ns-long molecular dynamics simulations on a model -sheet peptide in explicit solvent. The structural and conformational features under the different conditions were evaluated in terms of flexibility, secondary structure content, hydrogen-bonding pattern and percent of native contacts as a function of time. It was found that the different simulation methods strongly influence the dynamics of the peptide, confirming previous observations based on ideal peptide models simulated for much shorter times. Moreover, the results of our simulations prove once more that it is necessary to reach extremely long time scales to obtain enough statistics to accurately reproduce experimental NOE restraints even in the case of the PME method, despite its tendency to the stabilization of conformations which are structurally closely related to the ones derived through experiment. Possible implications regarding the stabilization and folding mechanisms, together with their relationship to the experimental study of peptide models, are discussed. 相似文献
82.
Moret I Gambaro A Piazza R Corami F Ravazzi C Andreoli C Truzzi C Lambertucci L Scarponi G 《Annali di chimica》2004,94(5-6):373-387
During the period March 1997-March 1998 dimethyl sulphide (DMS), dimethylsulphoniopropionate (DMSP) and carbon disulphide (CS2) were determined weekly in the water of the Lagoon of Venice, Italy (at three stations located in the Giudecca Canal, the San Secondo Canal and the Rio di San Nicolò). At the same time, the following hydrological and biological variables were also measured: tide height, temperature, transmittance, fluorescence, pH, salinity, chlorinity, sulphate, ammonia, nitrite, nitrate, phosphate, silicate, chlorophyll a, phaeopigments, phytoplankton (abundance and biomass). Principal component analysis (PCA), applied as a dimension reduction tool, made it possible to summarize multivariate information in a small number of components, which highlighted the relationships between the temporal evolutions of the sulphur compounds with hydrological and biological variables in the seasonal biogeochemical cycle of the lagoon. In particular the overall temporal cycle, which begins with the development of biological activity in late winter and spring, followed by the predominance of degradation processes during the late summer and the remineralization of nutrients in autumn, is clearly described in the plane of the first two principal components, together with the interrelationships between all the relevant variables. 相似文献
83.
J. Douady V. Barone Y. Ellinger R. Subra 《International journal of quantum chemistry》1980,17(2):211-233
A complete development of the PCILO method is presented for the INDO approximation. The introduction of exchange terms in the theoretical treatment is discussed and a detailed analysis of the successive contributions to the total energy is given. The method is applied to various conformational problems (geometry optimization, rotation, and inversion barriers). Its ability to deal with biological systems is tested on the acetylcholine neurotransmitter. Inversion barriers are highly improved with respect to the corresponding CNDO algorithm. A better account of σ-π exchange phenomena can be expected with the presented PCILO -INDO development. 相似文献
84.
6-Trifluoromethyl-12-acylindolo[1,2-c]quinazolines are prepared in high yield through the palladium-catalyzed reaction of bis(o-trifluoroacetamidophenyl)acetylene with aryl or vinyl halides and triflates. The reaction, which tolerates a variety of important functional groups, probably involves the formation of a 3-acyl-2-(o-trifluoroacetamidophenyl)indole intermediate, followed by its cyclization to the indoloquinazoline product. [reaction: see text] 相似文献
85.
Abbotto A Beverina L Bozio R Facchetti A Ferrante C Pagani GA Pedron D Signorini R 《Chemical communications (Cambridge, England)》2003,(17):2144-2145
The first examples of heterocycle-based multi-branched dyes with efficient two-photon absorption (TPA) activity are reported; the novel chromophores exhibit large TPA cross sections (as high as 1600 x 10(-50) cm4 s photon(-1) molecule(-1), measured with 150 fs laser pulses at 800 nm); a strong cooperative enhancement in the branched systems with respect to the one-dimensional sub-units is found. 相似文献
86.
Herein, we report the 1,2-dialkylation of simple feedstock acrylates for the synthesis of valuable tertiary carboxylic acids by merging Giese-type radical addition with an Ireland–Claisen rearrangement. Key to success is the utilization of the reductive radical-polar crossover concept under photocatalytic reaction conditions to force the [3,3]-sigmatropic rearrangement after alkyl radical addition to allyl acrylates. Using readily available alkyl boronic acids as radical progenitors, this redox-neutral, transition-metal-free protocol allows the mild formation of two C(sp3)–C(sp3) bonds, thus providing rapid access to complex tertiary carboxylic acids in a single step. Moreover, this strategy enables the efficient synthesis of highly attractive α,α-dialkylated γ-amino butyric acids (GABAs) when α-silyl amines are used as radical precursors – a structural motif that was still inaccessible in related transformations. Depending on the nature of the radical precursors and their inherent oxidation potentials, either a photoredox-induced radical chain or a solely photoredox mechanism is proposed to be operative.A photocatalytic 1,2-dialkylation of α-substituted acrylates is enabled by a reaction cascade combining reductive radical-polar crossover with the established Ireland–Claisen rearrangement for the synthesis of valuable tertiary carboxylic acids. 相似文献
87.
Treatment of methyl 2-chloro-2-phenylhydrazonoacetate (1) with 1-phenylsulphonylpropyne (3) in the presence of triethylamine gives pyrazole derivatives due to cycloadditions of a nitrile imine intermediate with 3 and with its rearranged product phenylsulphonylallene (4). 相似文献
88.
In this work we present a study of growth and characterization of ZnS/carbon nanotube (CNT) composites. The composites were prepared with a chemical mix technique and characterized by SEM analysis, Auger Electron Spectroscopy (AES) and Cathodoluminescence (CL) spectroscopy. The analyses show that the sample is formed by a direct contact between CNT and zinc sulfide. In particular, SEM images show CNTs wrapped around ZnS micrometer particles. Furthermore, AES spectroscopy shows the absence of chemical bonds between ZnS and CNT and that the sample homogeneity increases with the CNT amount in the composite.Finally CL studies show that our composites present a visible luminescence signal centered at about 500 nm, with a shift of luminescence emission peak linked to the amount of CNT in the sample. 相似文献
89.
90.