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971.
Time operator is studied on the basis of field quantization, where the difficulty stemming from Pauli?s theorem is circumvented by borrowing ideas from the covariant quantization of the bosonic string, i.e., one can remove the negative energy states by imposing Virasoro constraints. Applying the index theorem, one can show that in a different subspace of a Fock space, there is a different self-adjoint time operator. However, the self-adjoint time operator in the maximal subspace of the Fock space can also represent the self-adjoint time operator in the other subspaces, such that it can be taken as the single, universal time operator. Furthermore, a new insight on Pauli?s theorem is presented. 相似文献
972.
探讨了中药地龙水提液和醇提液有无促进成骨细胞增殖、分化和基质矿化的作用及对大鼠牙槽骨吸收疗效进行了研究.制备地龙的水相及醇相提取液,以小鼠成骨细胞株MC3T3-E1作为体外药效的试验模型,分别通过MTT法,流式细胞术,碱性磷酸酶活性测定,骨钙素检测和Von kossa基质矿化染色法观察上述药物的促细胞增殖、分化、基质矿化作用.以实验牙位龈正中注射脂多糖建立的SD大鼠实验性牙槽骨吸收作为体内药效试验模型,通过组织切片形态学骨密度观察和抗酒石酸酸性磷酸酶染色评价上述药物对大鼠实验性牙槽骨吸收的疗效.结果发现:1 mg·L-1 水提液,0.01 mg·L-1 和1 mg*L-1醇提液能显著促进MC3T3-E1细胞增殖.各浓度的水提液和醇提液均能使S期细胞百分率升高,G1期细胞百分率减少.0.01 mg*L-1水提液和1 mg·L-1 醇提液作用于细胞的第1~3 d内、100 mg·L-1醇提液作用第7~9 d内、100 mg·L-1水提液作用第10~12 d内可显著提高细胞骨钙素合成和分泌.0.01 mg·L-1水提液和醇提液,1 mg·L-1水提液可显著促进细胞体外基质矿化.地龙水提液和醇提液组的骨密度均有显著增高,破骨细胞数显著降低.阴性对照组至第30 d时牙槽骨仍可见大量破骨细胞.结果表明:地龙水相和醇相提取物中均存在较高活性的促成骨细胞增殖、分化和基质矿化的物质,且对实验性牙槽骨吸收模型有一定治疗作用,可抑制其牙槽骨吸收,促进成骨活动使其修复重建. 相似文献
973.
Guang‐Ri Xu Xin‐hua Qi Fengxia Yang Jae‐Joon Lee Ming‐Lu Xu Yu‐Ping Zhang Sunghyun Kim 《Electroanalysis》2009,21(22):2486-2490
A glassy carbon electrode having two polymer layers has been applied to selectively detect epinephrine. The inner layer formed by electropolymerization of macrocyclic nickel complex functioned as an electrocatalyst for epinephrine oxidation and the outer layer composed of hydrolyzed polyurethane γ‐benzyl L ‐glutamate as a screening layer. Differential pulse voltammetry showed almost 100% recovery of epinephrine even in 100‐fold excess of interferents. When applied to a dual glassy carbon electrode as an amperometric detector in flow injection analysis, a linear response over 0.1 μM and 10 μM was obtained. Recovery tested for 5‐fold diluted human urine samples was 97.5%. 相似文献
974.
975.
Xia Li Min Lu Qi Wu De‐shui Lv Xian‐Fu Lin 《Journal of polymer science. Part A, Polymer chemistry》2008,46(1):117-126
To develop designed polymer–drug conjugates, where the rate of drug liberation and hepatoma cell targeting function could be rationally and widely controlled, we facilely synthesized a series of novel, galactose‐functionalized polymer–acyclovir conjugates with different linkers and first reported the effect of the linker structure including the type of acyclovir‐linked bond (an ester bond or an amide bond) and relative length of the linker between acyclovir and the polymer main chain on release rate and targeting ability of conjugates. In vitro release studies showed that the cumulative released acyclovir from these polymer–acyclovir conjugates was between 24 and 65% in pH 1.2 glycine solution after 7 days. The ester bond more easily underwent hydrolysis than the amide bond. The longer the relative linker length was, the faster the acyclovir was released. The cell recognition experiments visualized using confocal laser scanning microscopy exhibited that the resultant galactose‐functionalized polymer–acyclovir conjugates had evident targeting to hepG2 cells, and targeting ability was also in connection with the relative length of linker. By choosing appropriate linker, cellular internalization of acyclovir could be well achieved. We consider these results to be helpful for the design of multifunctional polymeric prodrugs, in which the required release rate and targeting ability could be rationally controlled by predetermined molecular architecture. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 117–126, 2008 相似文献
976.
L J Shi Z M Ni S F Lu G Wang H L Qi Q X Su 《Science in China. Series B, Chemistry, life sciences & earth sciences》1989,32(7):816-821
Spindle fiber attachments (SFAs) were enriched in a fraction of nuclei isolated from mouse livers. The enrichment method combines sonication, treatment with 2 mol/L NaCl and high speed centrifugation. SFA was enriched 27-fold on the average (n = 4) when measured by radioimmunoassay. The basic method offers opportunities for further increases of yield and for the enrichment of SFA of other vertebrates. 相似文献
977.
978.
该文利用修正的带权 K- 泛函K2σ f, t2)w,p, 考虑Gamma算子在Lp~ (1≤p ≤∞)空间带权同时逼近, 给出了它的 B -型强逆不等式. 相似文献
979.
980.
QiGuiYANG 《数学学报(英文版)》2005,21(1):17-30
By using the Riccati technique and the technique, new oscillation criteria are obtained for the second order matrix differential system(P(t)Y′(t))′ r(t)P(t)Y′(t) Q(t)Y(t) = 0, t≥t0.These results in the present paper generalize and improve many known conclusions. Furthermore, some results are different from the most known ones in the sense that they are based on the information only on a sequence of subintervals of [t0, ∞), rather than on the whole half-line. In particular, our results complement a number of existing results and handle the ease that is not covered by the known criteria. 相似文献