Contrasting products in the reactions of Cr, Mo, and W atoms with H2O2: Argon matrix infrared spectra and theoretical calculations

Products in the reactions of H2O2 and H2, O2 mixtures have been observed by matrix infrared absorptions and identified through comparisons with vibrational frequencies calculated for these molecules. The chromium reactions are dominated by lower oxidation state products, whereas molybdenum and tungsten chemistry favors higher oxidation state products. For example chromium dihydroxide, Cr(OH)2, molybdenum hydride oxide, H2MoO2, and tungsten hydride oxide, H2WO2, were observed in laser-ablated metal atom reactions with H2O2, and calculations show that these are the most stable molecules for this stoichiometry. Chromium monohydroxide, CrOH, was identified through O-H and Cr-O stretching modes, while HWO was observed by W-H and W=O stretching modes. The metal oxyhydroxides, HMO(OH), were observed for all metals. However, reactions with two H2O2 molecules give OCr(OH)2, MoO2(OH)2, and WO2(OH)2. The relative stabilities of different structures for Cr, Mo, and W are due to different participations of occupied d orbitals. The reactivity of the cold metal atoms with H2O2 on annealing the solid argon matrix increases on going down the group.     

Tetraacyldiborates: selective and efficient acylation reagents suitable for multiple parallel synthetic applications

Boron-based mixed anhydrides are rapidly reactive, easy to prepare, cheap, efficient, and general acylating reagents capable of selectivity when chelation is possible. High yields of various esters, amides and thioesters are quickly obtainable and the products are easy to isolate in high purity. The method is readily used under multiple parallel synthesis conditions and is readily scaleable.     

A class of new silylating agents. II. A highly reactive reagent for introduction of the trimethylsilyl group.

Trimethylsilyl enol ethers of pentane-2,4-dione and methyl acetoacetate react rapidly with alcohols at room temperature without the need for catalytic assistance to give high isolated yields of trimethylsilyl ethers.     

A THEORETICAL STUDY OF EXCITONS IN CHLOROPHYLL a PHOTOSYSTEMS ON A PICOSECOND TIMESCALE

Abstract— The creation and decay of singlet excitons in structurally-explicit Chi a photosystems were investigated by numerical integration of the appropriate Master Equations. The antenna chlorophylls were excited by a simulated 6ps Gaussian light pulse. Positions and orientations for the antenna chlorophylls were randomly generated within regions whose size and shape were chosen to be appropriate for the particles observed in freeze-fractured photosynthetic membranes. Among the variables considered were chlorophyll concentration, depth of the trap (i.e. P680 or P700), and the R₀ parameter for Förster transfer. Among the properties considered were antenna fluorescence lifetime; detrapping rates; the instantaneous and integrated quantum yields for antenna fluorescence and intersystem crossing; and the instantaneous and integrated quantum yields for trap fluorescence, intersystem crossing, and photochemistry. A variety of experimental evidence was used as input to the computational model.     

Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?

Using unnatural amino acid mutagenesis, the binding site for serotonin at the novel Caenorhabditis elegans receptor MOD-1 has been probed. As with the closely related serotonin receptor 5-HT3, MOD-1 makes use of a strong cation-pi interaction between the ammonium of serotonin and the indole side chain of a tryptophan. However, the specific Trp used by MOD-1 is different from that used for 5-HT3 (and the nAChR), aligning with a residue more than 40 amino acids distant in sequence space and on a different "loop" of the agonist binding site. This suggests a significant rearrangement of the ligand on binding these two closely related receptors. It is suggested that, unlike enzymes, receptors and other signaling molecules may need only to deliver an agonist to a general binding region, rather than establishing precise drug-receptor interactions.     

Matrix infrared spectra and density functional calculations of transition metal hydrides and dihydrogen complexes

Metal hydrides are of considerable importance in chemical synthesis as intermediates in catalytic hydrogenation reactions. Transition metal atoms react with dihydrogen to produce metal dihydrides or dihydrogen complexes and these may be trapped in solid matrix samples for infrared spectroscopic study. The MH(2) or M(H(2)) molecules so formed react further to form higher MH(4), (H(2))MH(2), or M(H(2))(2), and MH(6), (H(2))(2)MH(2), or M(H(2))(3) hydrides or complexes depending on the metal. In this critical review these transition metal and dihydrogen reaction products are surveyed for Groups 3 though 12 and the contrasting behaviour in Groups 6 and 10 is discussed. Minimum energy structures and vibrational frequencies predicted by Density Functional Theory agree with the experimental results, strongly supporting the identification of novel binary transition metal hydride species, which the matrix-isolation method is well-suited to investigate. 104 references are cited.     

On the noble-gas-induced intersystem crossing for the CUO molecule: experimental and theoretical investigations of CUO(Ng)n (Ng = Ar, Kr, Xe; n = 1, 2, 3, 4) complexes in solid neon

Uranium atoms excited by laser ablation react with CO in excess neon to produce the novel CUO molecule, which forms distinct Ng complexes (Ng = Ar, Kr, Xe) when the heavier noble gases are added. The CUO(Ng) complexes are identified through CO isotopic and Ng substitution on the neon matrix infrared spectra and by comparison to DFT frequency calculations. The U-C and U-O stretching frequencies of CUO(Ng) complexes are slightly red-shifted from frequencies for the (1)Sigma(+) CUO ground state, which identifies singlet ground state CUO(Ng) complexes. In solid neon the CUO molecule is also a complex CUO(Ne)(n), and the CUO(Ne)(n-1)(Ng) complexes are likewise specified. The next singlet CUO(Ne)(x)(Ng)(2) complexes in excess neon follow in like manner. However, the higher CUO(Ne)(x)(Ng)(n) complex (n = 3, 4) stretching modes approach pure argon matrix CUO(Ar)(n) values and isotopic behavior, which are characterized as triplet ground state complexes by DFT frequency calculations. This work suggests that the singlet-triplet crossing occurs with 3 Ar, 3 Kr, or 4 Xe and a balance of Ne atoms coordinated to CUO in the neon matrix host.     

Fluorescence spectrum of the benzene radical cation in solid argon

Argon/benzene samples were condensed at 12 K with continuous argon resonance radiation. Laser excitation at 421 nm produced a weak emission with structure at 19770, 19140 and 18290 cm^?1, assigned to the ²A_2u → ²E_1g emission of C₆H₆⁺. Observation of 630 and 1480 cm^?1 intervals for the vibrations v₁₈ (e_2g) and v₆ (e_2g), respectively, supports this assignment.     

Synthesis of novel 2-azabicyclo[2.2.0]- and [2.1.1]hexanols

Methyl- and phenyl-substituted N-(ethoxycarbonyl)-2-azabicyclo[2.2.0]hex-5-enes 6 were reacted with NBS in wet DMSO to afford bromohydrins. Mixtures of unrearranged 6-exo-bromo-5-endo-hydroxy-2-azabicyclo[2.2.0]hexanes 7a,b and rearranged 5-anti-bromo-6-anti-hydroxy-2-azabicyclo[2.1.1]hexanes 8a,b were formed stereoselectively from the parent alkene 6a and 4-methyl alkene 6b. The 5-methyl alkene 6c affords only unrearranged bromohydrin 7c and dibromohydrin 9. By contrast, solely rearranged 3-endo-substituted-2-azabicyclo[2.1.1]hexane bromohydrins 8d-f result from additions to 3-endo-methyl alkene 6d, 3-endo-4-dimethyl alkene 6e, and 3-endo-phenyl alkene 6f. As an alternative route to bromohydrins, the parent 5,6-exo-epoxide 10a and 5-endo-methyl-5,6-exo-epoxide 10b were ring opened with bromine/triphenylphosphine to afford unrearranged 5-endo-bromo-6-exo-hydroxy-2-azabicyclo[2.2.0]hexanes 11a,b, while the 3-endo-methyl epoxide 10c afforded solely the rearranged 5-anti-bromo-6-anti-hydroxy-3-exo-methyl-2-azabicyclo[2.1.1]hexane isomer 8g. Tributyltin hydride reduction of bromohydrins 7a,b and 11a afforded novel 2-azabicyclo[2.2.0]hexan-5-ols 13a,b and -6-ol 14, and bromohydrins 8a,b, 8d-g afforded new 2-azabicyclo[2.1.1]-hexan-5-ols 15a,b and 15d-g.