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101.
A sensitive LC/MS/MS assay for determining zidovudine (ZDV) and lamivudine (3TC) in human plasma was validated to support antiretroviral pharmacology research programs. After addition of stable labeled isotopic zidovudine (ZDV‐IS) and lamivudine (3TC‐IS) as internal standard, a solid‐phase extraction was performed with an Oasis HLB 1 cm3 cartridge, with recoveries of 92.3% for ZDV and 93.9% for 3TC. A Phenomonex Synergi Hydro‐RP (2.0 × 150 mm) reversed‐phase analytical column was utilized for chromatographic separation. The mobile phase consisted of an aqueous solution of 15% acetonitrile and 0.1% acetic acid. Detection was accomplished by ESI/MS/MS in the positive ion mode, monitoring 268/127, 271/130, 230/112 and 233/115 transitions, for ZDV, ZDV‐IS, 3TC and 3TC‐IS, respectively. The method was linear from 1 to 3000 ng/mL with a minimum quantifiable limit of 1 ng/mL when 100 μL of plasma was analyzed. Validation results demonstrated high accuracy (≤8.3% deviation) and high precision (≤10% CV) for the quality control samples. The method was also shown to be specific and reproducible. The value of the high sensitivity was demonstrated by quantitation of approximately 100 existing samples that had ZDV below the limit of quantitation using a previously validated, less sensitive HPLC‐UV method utilized in the laboratory. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
102.
The graph-theoretic Ramsey numbers are notoriously difficult to calculate. In fact, for the two-color Ramsey numbers R(m,n) with m, n≥3, only nine are currently known. We present a quantum algorithm for the computation of the Ramsey numbers R(m,n). We show how the computation of R(m,n) can be mapped to a combinatorial optimization problem whose solution can be found using adiabatic quantum evolution. We numerically simulate this adiabatic quantum algorithm and show that it correctly determines the Ramsey numbers R(3,3) and R(2,s) for 5≤s≤7. We then discuss the algorithm's experimental implementation, and close by showing that Ramsey number computation belongs to the quantum complexity class quantum Merlin Arthur. 相似文献
103.
A laboratory experiment for senior undergraduate students, the determination of the rate coefficient for the reaction of oxygen atoms with hexafluoropropene, is presented. This reaction has the advantage of not having any important secondary reactions. This laboratory experiment introduces the undergraduate physical chemistry student to advanced kinetic techniques and provides a test of the fundamental principles of chemical kinetics. 相似文献
104.
The preceding paper Strong statements of analysisby A. R. D. Mathias defends a so-called full-blooded set theorywithout full detail [3]. He again objects to a weak set theorywhich he calls Mac, in which the usual ZermeloFraenkelseparation scheme is required only for formulas with suitablyrestricted quantifiers. I had proposed that suchseparation is adequate for all standard uses of set theory inmathematics. But Mathias has not produced any counter examplesof actual mathematics which requires the use of a stronger separation. 相似文献
105.
Qusai Hassan Rudraksha Dutta Majumdar Bing Wu Daniel Lane Maryam Tabatabaei-Anraki Ronald Soong Myrna J. Simpson Andre J. Simpson 《Magnetic resonance in chemistry : MRC》2019,57(2-3):69-81
Proton nuclear magnetic resonance (NMR) spectra of intact biological samples often show strong contributions from lipids, which overlap with signals of interest from small metabolites. Pioneering work by Diserens et al. demonstrated that the relative differences in diffusivity and relaxation of lipids versus small metabolites could be exploited to suppress lipid signals, in high-resolution magic angle spinning (HR-MAS) NMR spectroscopy. In solution-state NMR, suspended samples can exhibit very broad water signals, which are challenging to suppress. Here, improved water suppression is incorporated into the sequence, and the Carr-Purcell-Meiboom-Gill sequence (CPMG) train is replaced with a low-power adiabatic spinlock that reduces heating and spectral artefacts seen with longer CPMG filters. The result is a robust sequence that works well in both HR-MAS as well as static solution-state samples. Applications are also extended to include in vivo organisms. For solution-state NMR, samples containing significant amount of fats such as milk and hemp hearts seeds are used to demonstrate the technique. For HR-MAS, living earthworms (Eisenia fetida) and freshwater shrimp (Hyalella azteca) are used for in vivo applications. Lipid suppression techniques are essential for non-invasive NMR-based analysis of biological samples with a high-lipid content and adds to the suite of experiments advantageous for in vivo environmental metabolomics. 相似文献
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Wm.C. Lane T.H. Edwards James R. Gillis Francis S. Bonomo Frank J. Murcray 《Journal of Molecular Spectroscopy》1985,111(2):320-326
We have extended our analysis of the (010) vibrational state of H2S, this time using Watson's A-reduced Hamiltonian (through P8 terms) in the I′ rotational representation. We have determined separate sets of (010) upper state constants for each isotopomer (H232S, H233S, and H234S) by fitting the ν2 spectral lines, keeping the ground state constants fixed to the values determined by Flaud, Camy-Peyret, and Johns. Determinable coefficients for H232S and a slightly revised set of ν2 line assignments for H233S and H234S are also reported. 相似文献
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110.
Ahlen S Ambrosio M Antolini R Auriemma G Baker R Baldini A Barbarino GC Barish BC Battistoni G Bellotti R Bemporad C Bernardini P Bilokon H Bisi V Bloise C Bussino S Cafagna F Calicchio M Campana P Campana D Carboni M Cecchini S Cei F Chiarella V Chiera C Cobis A Cormack R Corona A Coutu S DeCataldo G Dekhissi H DeMarzo C De Vincenzi M Di Credico A Diehl E Erriquez O Favuzzi C Ficenec D Forti C Foti L Fusco P Giacomelli G Giannini G Giglietto N Giubellino P Grassi M Green P Grillo A Guarino F 《Physical review letters》1992,69(13):1860-1863