We study the properties of spin-orbit coupled and harmonically trapped quasi-two-dimensional Fermi gas with tunable s-wave interaction between the two spin species. We adapt an effective two-channel model which takes the excited states occupation in the strongly confined axial direction into consideration by introducing dressed molecules in the closed channel, and use a Bogoliubovde Gennes (BdG) formalism to go beyond local density approximation. We find that both the in-trap phase structure and density distribution can be significantly modified near a wide Feshbach resonance compared with the single-channel model without the dressed molecules. Our findings will be helpful for the experimental search for the topological superfluid phase in ultracold Fermi gases. 相似文献
A one-equation turbulence model which relies on the turbulent kinetic energy transport equation has been developed to predict the flow properties of the recirculating flows. The turbulent eddy-viscosity coefficient is computed from a recalibrated Bradshaw’s assumption that the constant a1 = 0.31 is recalibrated to a function based on a set of direct numerical simulation (DNS) data. The values of dissipation of turbulent kinetic energy consist of the near-wall part and isotropic part, and the isotropic part involves the von Karman length scale as the turbulent length scale. The performance of the new model is evaluated by the results from DNS for fully developed turbulence channel flow with a wide range of Reynolds numbers. However, the computed result of the recirculating flow at the separated bubble of NACA4412 demonstrates that an increase is needed on the turbulent dissipation, and this leads to an advanced tuning on the self-adjusted function. The improved model predicts better results in both the non-equilibrium and equilibrium flows, e.g. channel flows, backward-facing step flow and hump in a channel. 相似文献
A new method of fiber-optic based beam shaping is investigated both numerically and experimentally. A cylindrically symmetric method of lines (MoLs) is developed to simulate the device. The device is fabricated by fusion splicing a predetermined length of multimode fiber (MMF) to a single-mode fiber. The multimode interference (MMI) effects create ring-shaped field profiles at certain positions inside the MMF. The shaped beam can be used in medical applications requiring particular irradiation patterns. 相似文献
Some photonic crystals (PCs) consisting of complex lattices of dielectric cylinders can have an effective refraction index (neff) of −1. Subwavelength imaging by a slab of a honeycomb PC of dielectric cylinders with neff=−1 is investigated and an open resonator with a quality factor higher than 3000 is designed with the same PC. Air–PC interfaces with low reflection are also used for the slab lens and open resonator. 相似文献
Indoleamine 2,3-dioxygenase (IDO), an immune checkpoint protein, can cause the depletion of tryptophan (Trp) and accumulation of its metabolite of kynurenine (Kyn) in cancer cells, and generates the immunosuppressive microenvironment that supports tumor cell growth. A novel immunoregulatory prodrug micelle based on polyethylene glycol-derivatized an IDO-selective inhibitor of 1-methyltryptophan (1-MT), PEG-Fmoc-1-MT, was developed for inhibiting the IDO activity of the conversion of Trp to Kyn in tumor microenvironments. To investigate the 1-MT distribution and Trp/Kyn ratios in mice tumors with PEG-Fmoc-1-MT prodrug micelles treatment, a HPLC–MS/MS method for simultaneous determination of 1-MT and IDO biomakers of Trp and Kyn in mouse tumors was developed and validated. Triple-quadrupole mass spectrometry with positive electrospray ionization as source ionization in multiple reaction monitoring at m/z 219.0?→?160.1, 205.0?→?118.2, 209.0?→?146.1 and 249.3?→?148.3 was used for determination of 1-MT, Trp, Kyn and matrine (internal standard). The method demonstrated good linearity at the concentrations ranging from 10 to 10,000 ng/mL and lower limits of quantitation of 1 ng/mL for 1-MT, Trp and Kyn, respectively. The validated method was successfully applied to 1-MT tumor biodistribution and Trp/Kyn ratio studies in 4T1 tumor bearing mice i.v. with PEG-Fmoc-1-MT prodrug micelles. The mice tumors with PEG-Fmoc-1-MT prodrug micelles treatment exhibited higher 1-MT accumulation and lower Trp/Kyn ratio, in comparison with those of mice with 1-MT solution treatment. The developed PEG-Fmoc-1-MT prodrug micelles could be a promising IDO immunoregulatory prodrug micelles for cancer immunotherapy.
Thermophoresis of charged spheroids has been widely applied in biology and medical science. In this work, we report an analysis of the anisotropic thermophoresis of diluted spheroidal colloids in aqueous media for extremely thin EDL cases. Under the boundary layer approximation, we formulate the thermophoretic velocity, the thermophoretic force, and the thermodiffusion coefficient of a randomly dispersed spheroid. The parametric studies show that under the aforementioned conditions, the thermophoresis is anisotropic and its thermodiffusion coefficient should be considered as a vector, DT. The thermodiffusion coefficient values and directions of DT are strongly related to the aspect ratio and the angle θ between the externally applied temperature gradient and the particle's axis of revolution: The increasing aspect ratio enlarges the thermodiffusion coefficient value DT of prolate (oblate) spheroids to a constant value when θ < 60° (θ > 45°), and it reduces DT of prolate (oblate) spheroids to a constant value when θ > 60° (θ < 45°). The thermodiffusion coefficient direction of both prolate and oblate spheroids deviates slightly from −∇T∞ for a small aspect ratio, and such deviation becomes serious for a large aspect ratio. 相似文献
Journal of Radioanalytical and Nuclear Chemistry - To long-term immobilization of secondary iodine-waste, iodine loaded silver-coated silica-gel (AgIs), glass-powder was used to directly solidify... 相似文献