排序方式: 共有51条查询结果,搜索用时 10 毫秒
31.
Bilal Elhajjar Abdelkader Mojtabi Manuel Marcoux Marie-Catherine Charrier-Mojtabi 《Comptes Rendus Mecanique》2006,334(10):621-627
We propose an analytical and numerical study of the combined action of the thermodiffusion and the convection in a binary mixture. The combination of these two phenomena is called thermogravitational diffusion. We are interested in quantifying the separation in a horizontal parallelepipedic cavity filled with a binary mixture and subjected to a constant horizontal temperature gradient on the two horizontal walls, the other walls being thermally insulated and impermeable. This new procedure is different from the classical one where the cavity is vertical and differentially heated on the two vertical walls. To cite this article: B. Elhajjar et al., C. R. Mecanique 334 (2006). 相似文献
32.
François‐Ludovic Sauvage Nicolas Picard Franck Saint‐Marcoux Jean‐Michel Gaulier Gérard Lachâtre Pierre Marquet 《Journal of separation science》2009,32(18):3074-3083
LC coupled to single (LC–MS) and tandem (LC–MS/MS) mass spectrometry is recognized as the most powerful analytical tools for metabolic studies in drug discovery. In this article, we describe five cases illustrating the utility of screening xenobiotic metabolites in routine analysis of forensic samples using LC–MS/MS. Analyses were performed using a previously published LC–MS/MS general unknown screening (GUS) procedure developed using a hybrid linear IT–tandem mass spectrometer. In each of the cases presented, the presence of metabolites of xenobiotics was suspected after analyzing urine samples. In two cases, the parent drug was also detected and the metabolites were merely useful to confirm drug intake, but in three other cases, metabolite detection was of actual forensic interest. The presented results indicate that: (i) the GUS procedure developed is useful to detect a large variety of drug metabolites, which would have been hardly detected using targeted methods in the context of clinical or forensic toxicology; (ii) metabolite structure can generally be inferred from their “enhanced” product ion scan spectra; and (iii) structure confirmation can be achieved through in vitro metabolic experiments or through the analysis of urine samples from individuals taking the parent drug. 相似文献
33.
In this article we provide generalizations of Specht's theorem which states that two n × n matrices A and B are unitarily equivalent if and only if all traces of words in two non-commuting variables applied to the pairs (A, A*) and (B, B*) coincide. First, we obtain conditions which allow us to extend this to simultaneous similarity or unitary equivalence of families of operators, and secondly, we show that it suffices to consider a more restricted family of functions when comparing traces. Our results do not require the traces of words in (A, A*) and (B, B*) to coincide, but only to be close. 相似文献
34.
Claire Simonneau Bérénice Leclercq Alexandra Mougel Eric Adriaenssens Charlotte Paquet Laurent Raibaut Nathalie Ollivier Hervé Drobecq Julien Marcoux Sarah Cianférani David Tulasne Hugo de Jonge Oleg Melnyk Jér?me Vicogne 《Chemical science》2015,6(3):2110-2121
The development of MET receptor agonists is an important goal in regenerative medicine, but is limited by the complexity and incomplete understanding of its interaction with HGF/SF (Hepatocyte Growth Factor/Scatter Factor). NK1 is a natural occurring agonist comprising the N-terminal (N) and the first kringle (K1) domains of HGF/SF. In the presence of heparin, NK1 can self-associate into a “head to tail” dimer which is considered as the minimal structural module able to trigger MET dimerization and activation whereas isolated K1 and N domains showed a weak or a complete lack of agonistic activity respectively. Starting from these structural and biological observations, we investigated whether it was possible to recapitulate the biological properties of NK1 using a new molecular architecture of isolated N or K1 domains. Therefore, we engineered multivalent N or K1 scaffolds by combining synthetic and homogeneous site-specifically biotinylated N and K1 domains (NB and K1B) and streptavidin (S). NB alone or in complex failed to activate MET signaling and to trigger cellular phenotypes. Importantly and to the contrary of K1B alone, the semi-synthetic K1B/S complex mimicked NK1 MET agonist activity in cell scattering, morphogenesis and survival phenotypic assays. Impressively, K1B/S complex stimulated in vivo angiogenesis and, when injected in mice, protected the liver against fulminant hepatitis in a MET dependent manner whereas NK1 and HGF were substantially less potent. These data reveal that without N domain, proper multimerization of K1 domain is a promising strategy for the rational design of powerful MET agonists. 相似文献
35.
A general preparation of pyridines and pyridones via the annulation of ketones and esters 总被引:1,自引:0,他引:1
Marcoux JF Marcotte FA Wu J Dormer PG Davies IW Hughes D Reider PJ 《The Journal of organic chemistry》2001,66(12):4194-4199
A general preparation of pyridines 4a-f from stabilized ketones 3a-c and aryl ketones 3d-f is described. The annulation of stabilized esters 3g,h gives access to the corresponding 2-pyridones 4g,h. The annulation reactions proceed in fair to excellent yields (46-87%) with vinamidinium hexafluorophosphate salts 2a-d containing electron-withdrawing groups at the beta-position. The mechanism of the reaction was investigated by NMR and proceeds through the formation of a dienaminone intermediate. 相似文献
36.
B. E. Forrest L. W. Marcoux 《Transactions of the American Mathematical Society》2002,354(4):1435-1452
Let and be unital Banach algebras, and let be a Banach -module. Then becomes a triangular Banach algebra when equipped with the Banach space norm . A Banach algebra is said to be -weakly amenable if all derivations from into its dual space are inner. In this paper we investigate Arens regularity and -weak amenability of a triangular Banach algebra in relation to that of the algebras , and their action on the module .
37.
D. A. Herrero has defined the (U+K)-orbit of an operatorT acting on an Hilbert space as (U+K)(T)={R
–1
TR: R invertible of the form unitary plus compact}. In this paper we consider the (U+K)-orbit and the closure thereof for bilateral and unilateral weighted shifts. In particular, we determine which shifts are in the (U+K)-orbits of injective weighted shifts and which shifts are in the closure of the (U+K)-orbit of periodic injective shifts. Also, the closure of the (U+K)-orbit of injective essentially normal shifts is determined.Research supported in part by an NSERC operating grant. 相似文献
38.
39.
We establish finite- and infinite-dimensional versions of the following assertion. If M is a matrix with the property that whenever P and Q are diagonal projections with P?Q, the spectrum of PMP (considered as an operator on the range of P) is contained in that of QMQ (considered as an operator on the range of Q), then there is a permutation matrix U such that U−1MU is triangular. 相似文献
40.
Marcoux JF Corley EG Rossen K Pye P Wu J Robbins MA Davies IW Larsen RD Reider PJ 《Organic letters》2000,2(15):2339-2341
alpha-Aryl ketones react with vinamidinium hexafluorophosphate salts to give access to the corresponding 3-arylpyridines. The annulation reactions proceed in good to excellent yields with vinamidinium salts containing electron-withdrawing groups at the beta-position (R(2)). The reaction was applied to the preparation of the COX-2 specific inhibitor 5-chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine (1), as well as a series of analogues. 相似文献