Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo

The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of tumor growth, pronounced vascular damage (thrombosis and destruction of vascular walls) and eventual tumor necrosis.     

Hopanoids of methylotropic acetobacteria

Squalene, 35-methoxyho-6-ene-32R,33R,34S-triol, hop-22(29)-ene, and hopan-22-ol have been isolated fromAcetobacter sp. VSB 917. The structures of the substances isolated and of the 35-methoxyhop-6-ene-32R,33R,34S-triol triacetate obtained have been established by IR, mass, and¹H and¹³C NMR spectroscopies.Vitaminy Scientific-Production Association, Moscow. Translated from Khimiya Prirodnykh Soedinenii, Nos. 3,4, pp. 367–372, May–August, 1992.     

Nucleophilic reactions of polydialkylcyclosilazanes

A study is made of the catalytic condensation polymerization of polydialkylcyclosilazanes [RR'SiNH]_n (n=3,4; R=CH₃, C₂H₅; R'=C₂H₅, C₄H₉, C₆H₁₃, C₉H₁₉) in the presence of small amounts of nucleophilic reagents, to give compounds of the general type R₅R₆'Si₆N₃(NH)₂ and oligomers. The reactivities of polydialkylsilazanes decrease with increase in aliphatic group chain length.