低阻抗大面积二极管的研制

采用高纯石墨环状阴极和有机玻璃绝缘子,研制了一套低阻抗大面积二极管系统。使用理论计算和数值模拟方法对二极管进行优化设计,在保证绝缘要求的同时,尽量优化二极管轴向长度和内外筒距离以减小二极管的回路电感。实验结果表明,优化后的二极管能在200 kV左右的电压上稳定工作,绝缘结构未发生击穿现象;实验中最高输出电压为213 kV,电流为221 kA,特性阻抗约为1 ,电流密度为8 kA/cm2,脉宽(FWHM)为50 ns。     

“闪光二号”5 T脉冲强磁场装置

为了满足闪光二号加速器材料热力学效应研究的新需求,设计了一套电容器储能型脉冲强磁场装置。装置主要由储能电容器、半导体放电开关、磁场线圈及高压恒流充电源组成。磁场线圈中心处最大磁感应强度可达5 T,并且可以通过调整磁场线圈与二极管的相对位置实现磁透镜比的调节。通过理论计算和数值模拟相结合的方法对脉冲强磁场的关键参数进行了分析,然后进行了脉冲强磁场的工程设计,最后使用该强磁场装置进行了实验研究。强磁场实验中,当储能电容器充电21 kV时,在磁场线圈中心处获得了5.3 T脉冲强磁场。     

基于多尺度分解的超光谱图像异常检测

提出了一种基于多尺度分解的超光谱图像异常检测算法。在目标和背景均未知的前提下,利用光谱和空间两种信息完成对异常目标信号的定位,从而实现超光谱遥感数据中异常目标检测。首先利用非下采样塔式变换对超光谱图像进行分解,将其划分为不同尺度子块;然后依据超光谱图像同一波段不同尺度空间内相邻系数的相关性,采用不同波段各个尺度空间的反锐化掩模方法优化背景数据分布,从而抑制异常数据对背景的干扰;最后利用设计的核RX算子得到异常目标检测结果。为验证方法的有效性,利用真实和模拟的AVIRIS数据进行了实验,并与经典RX算法相比较,实验结果表明,基于非下采样塔式分解的异常检测方法具有更好的检测性能和较低的虚警。     

3 MV多级多通道缩比开关自击穿特性

通过短接电极间隙,开展了3 MV多级多通道缩比开关不同间隙级数和单独触发间隙的自击穿特性分析,结果表明：自击穿电压随电极间隙距离不是线性增加,与Bradley经验公式存在差距。采用Ansoft软件模拟了实验开关不同级数的电场分布,得到不同级数开关电场分布的不均匀系数。结合缩比开关自击穿实验数据、Bradley经验公式和电场分布不均匀系数,在Bradley经验公式中加入开关作用时间因素和电场不均匀系数,得到一个Bradley外推公式,能较好地反应多级多通道气体开关的自击穿电压,使3 MV实际开关自击穿电压理论值与实验值误差减小到5%。     

Diluting the Resistance of Built-in Electric Fields in Oxygen Vacancy-enriched Ru/NiMoO4-x for Enhanced Hydrogen Spillover in Alkaline Seawater Splitting

Recently, hydrogen spillover based binary (HSBB) catalysts have received widespread attention due to the sufficiently utilized reaction sites. However, the specific regulation mechanism of spillover intensity is still unclear. Herein, we have fabricated oxygen vacancies enriched Ru/NiMoO_4-x to investigate the internal relationship between electron supply and mechanism of hydrogen spillover enhancement. The DFT calculations cooperate with in situ Raman spectrum to uncover that the H* spillover from NiMoO_4-x to Ru. Meanwhile, oxygen vacancies weakened the electron supply from Ru to NiMoO_4-x, which contributes to dilute the resistance of built-in electric field (BEF) for hydrogen spillover. In addition, the higher ion concentration in electrolyte will promote the H* adsorption step obviously, which is demonstrated by in situ EIS tests. As a result, the Ru/NiMoO_4-x exhibits a low overpotential of 206 mV at 3.0 A cm⁻², a small Tafel slope of 28.8 mV dec⁻¹, and an excellent durability of 550 h at the current density of 0.5 A cm⁻² for HER in 1.0 M KOH seawater.     

Farbstoffe

Ohne Zusammenfassung     

Untersuchung von Harn, Blut und sonstigem biologischen Material

Ohne Zusammenfassung     

Piezo1 Mechano-Activation Is Augmented by Resveratrol and Differs between Colorectal Cancer Cells of Primary and Metastatic Origin

Cancer cells must survive aberrant fluid shear stress (FSS) in the circulation to metastasize. Herein, we investigate the role that FSS has on colorectal cancer cell apoptosis, proliferation, membrane damage, calcium influx, and therapeutic sensitization. We tested this using SW480 (primary tumor) and SW620 cells (lymph node metastasis) derived from the same patient. The cells were exposed to either shear pulses, modeling millisecond intervals of high FSS seen in regions of turbulent flow, or sustained shear to model average magnitudes experienced by circulating tumor cells. SW480 cells were significantly more sensitive to FSS-induced death than their metastatic counterparts. Shear pulses caused significant cell membrane damage, while constant shear decreased cell proliferation and increased the expression of CD133. To investigate the role of mechanosensitive ion channels, we treated cells with the Piezo1 agonist Yoda1, which increased intracellular calcium. Pretreatment with resveratrol further increased the calcium influx via the lipid-raft colocalization of Piezo1. However, minimal changes in apoptosis were observed due to calcium saturation, as predicted via a computational model of apoptosis. Furthermore, SW480 cells had increased levels of Piezo1, calcium influx, and TRAIL-mediated apoptosis compared to SW620 cells, highlighting differences in the mechano-activation of metastatic cells, which may be a necessary element for successful dissemination in vivo.     

波纹误差对同轴布拉格结构反射特性的影响

利用模式匹配法建立了分析波纹参数具有随机误差的矩形槽同轴布拉格结构反射特性的理论模型,并以一个以基模（TEM）工作于220 GHz附近的矩形槽同轴布拉格结构为例,研究了矩形凹槽的深度、宽度、周期长度以及位置的随机误差对其反射率频率响应的影响。数值模拟结果表明：在给定的误差范围条件下,凹槽宽度与位置的随机误差对该结构的反射性能影响较小,而凹槽深度与周期长度的随机误差是影响结构反射特性的主要因素,因此在结构的加工制备过程中应视器件性能要求严格控制两者的制造公差。