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961.
Daeun You Yisun Jeong Sun Young Yoon Sung A Kim Eunji Lo Seok Won Kim Jeong Eon Lee Seok Jin Nam Sangmin Kim 《Molecules (Basel, Switzerland)》2021,26(12)
Interleukin-1 (IL1) is a proinflammatory cytokine and promotes cancer cell proliferation and invasiveness in a diversity of cancers, such as breast and colon cancer. Here, we focused on the pharmacological effect of Entelon® (ETL) on the tumorigenesis of triple-negative breast cancer (TNBC) cells by IL1-alpha (IL1A). IL1A enhanced the cell growth and invasiveness of TNBC cells. We observed that abnormal IL1A induction is related with the poor prognosis of TNBC patients. IL1A also increased a variety of chemokines such as CCL2 and IL8. Interestingly, IL1A expression was reduced by the ETL treatment. Here, we found that ETL significantly decreased the MEK/ERK signaling pathway in TNBC cells. IL1A expression was reduced by UO126. Lastly, we studied the effect of ETL on the metastatic potential of TNBC cells. Our results showed that ETL significantly reduced the lung metastasis of TNBC cells. Our results showed that IL1A expression was regulated by the MEK/ERK- and PI3K/AKT-dependent pathway. Taken together, ETL inhibited the MEK/ERK and PI3K/AKT signaling pathway and suppressing the lung metastasis of TNBC cells through downregulation of IL1A. Therefore, we propose the possibility of ETL as an effective adjuvant for treating TNBC. 相似文献
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966.
Christopher F. H. Nam John A. D. Aston Adam M. Johansen 《Annals of the Institute of Statistical Mathematics》2014,66(3):553-575
The majority of modelling and inference regarding Hidden Markov Models (HMMs) assumes that the number of underlying states is known a priori. However, this is often not the case and thus determining the appropriate number of underlying states for a HMM is of considerable interest. This paper proposes the use of a parallel sequential Monte Carlo samplers framework to approximate the posterior distribution of the number of states. This requires no additional computational effort if approximating parameter posteriors conditioned on the number of states is also necessary. The proposed strategy is evaluated on a comprehensive set of simulated data and shown to outperform the state of the art in this area: although the approach is simple, it provides good performance by fully exploiting the particular structure of the problem. An application to business cycle analysis is also presented. 相似文献
967.
Yunsun Nam 《Graphs and Combinatorics》2010,26(6):805-813
In this paper, we obtain some sufficient conditions based on binding number for a graph to have a connected factor with degree restrictions. Let α and k be positive integers with α + k ≥ 4. Let G be a connected graph with a spanning subgraph F, each component of which has order at least α. We show that if the binding number of G is greater than (α k − α)/(α k − α −1) (k ≥ 2) and α/(α −2) (k = 1) then G has a connected subgraph which has F and in which every vertex v has degree at most deg F (v) + k. From the result, we derive various sufficient conditions for a graph to have a connected [a, b]-factor. 相似文献
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The European Physical Journal C - Primordial black holes (PBHs) are convenient candidates to explain the elusive dark matter (DM). However, years of constraints from various astronomical... 相似文献
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Christian Brennecke Phan Thành Nam Marcin Napiórkowski Benjamin Schlein 《Annales de l'Institut Henri Poincaré (C) Analyse Non Linéaire》2019,36(5):1201-1235
We consider a system of N bosons interacting through a singular two-body potential scaling with N and having the form , for an arbitrary parameter . We provide a norm-approximation for the many-body evolution of initial data exhibiting Bose–Einstein condensation in terms of a cubic nonlinear Schrödinger equation for the condensate wave function and of a unitary Fock space evolution with a generator quadratic in creation and annihilation operators for the fluctuations. 相似文献
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