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51.
Md. Khalid Anwer Essam A. Ali Muzaffar Iqbal Mohammed Muqtader Ahmed Mohammed F. Aldawsari Ahmed Al Saqr Mohd Nazam Ansari M. Ali Aboudzadeh 《Molecules (Basel, Switzerland)》2022,27(1)
Baricitinib (BTB) is an orally administered Janus kinase inhibitor, therapeutically used for the treatment of rheumatoid arthritis. Recently it has also been approved for the treatment of COVID-19 infection. In this study, four different BTB-loaded lipids (stearin)-polymer (Poly(d,l-lactide-co-glycolide)) hybrid nanoparticles (B-PLN1 to B-PLN4) were prepared by the single-step nanoprecipitation method. Next, they were characterised in terms of physicochemical properties such as particle size, zeta potential (ζP), polydispersity index (PDI), entrapment efficiency (EE) and drug loading (DL). Based on preliminary evaluation, the B-PLN4 was regarded as the optimised formulation with particle size (272 ± 7.6 nm), PDI (0.225), ζP (−36.5 ± 3.1 mV), %EE (71.6 ± 1.5%) and %DL (2.87 ± 0.42%). This formulation (B-PLN4) was further assessed concerning morphology, in vitro release, and in vivo pharmacokinetic studies in rats. The in vitro release profile exhibited a sustained release pattern well-fitted by the Korsmeyer–Peppas kinetic model (R2 = 0.879). The in vivo pharmacokinetic data showed an enhancement (2.92 times more) in bioavailability in comparison to the normal suspension of pure BTB. These data concluded that the formulated lipid-polymer hybrid nanoparticles could be a promising drug delivery option to enhance the bioavailability of BTB. Overall, this study provides a scientific basis for future studies on the entrapment efficiency of lipid-polymer hybrid systems as promising carriers for overcoming pharmacokinetic limitations. 相似文献
52.
Ramajayam Govindan Mohamed El-Sherbiny Khalid Mohamed Morsy Ibraheem Srinivasan Narasimhan Mohamed EL-Dosoky Mohamed Salama Fazil Ahmad Selvaraj Jayaraman Vishnu Priya Veeraraghavan Srinivasan Vengadassalapathy Surapaneni Krishna Mohan Vidhya Rekha Umapathy Gayathri Rengasamy Shazia Fathima Jaffer Hussain Maheshkumar Poomarimuthu Senthilkumar Kalimuthu 《Molecules (Basel, Switzerland)》2022,27(3)
53.
Transport in Porous Media - This work investigates the interplay of gas transport in the microcracks and matrix of shale using He and $$\hbox {CO}_2$$ via transient upstream pressure-pulse-decay... 相似文献
54.
55.
Kamal YT Mohammed Musthaba S Singh M Parveen R Ahmad S Baboota S Ali I Siddiqui KM Arif Zaidi SM 《Biomedical chromatography : BMC》2012,26(10):1183-1190
An attempt has been made to develop and validate a simultaneous HPLC method for novel approach of drug release via oil‐in‐water (o/w) nanoemulsion formulation and Habb‐e‐Khardal Unani tablet containing piperine and guggul sterones E and Z as main ingredients. Nanoemulsion was prepared by titration method using sefsol‐218 as an oily phase, cremophor‐EL as a surfactant, transcutol as a co‐surfactant and distilled water as an aqueous phase. The formulation was optimized on the basis of thermodynamic stability and dispersibilty test. The nanoformulation was evaluated for particle size, surface morphology, electrical conductivity and viscosity determination. The in vitro dissolution was carried out by dialysis bag method. Drugs were quantified using an HPLC method developed in‐house with a C18 column as stationary phase and acetonitrile and water as mobile phase at λmax of 240 nm. The optimized formulation showed higher drug release, lower droplet size and less viscosity as compared with the conventional Habb‐e‐Khardal Unani tablet. The present study illustrated the potential of nanoemulsion dosage form in improving biopharmaceutic performance of piperine and guggul sterone. The HPLC method was also found to be quite sufficient for the routine quality control of formulations containing piperine and guggul sterone E and Z as ingredients and also for in vitro drug release studies. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
56.
Lubna Atta Ruqaiya Khalil Khalid Mohammed Khan Moatter Zehra Faiza Saleem Mohammad Nur-e-Alam Zaheer Ul-Haq 《Molecules (Basel, Switzerland)》2022,27(4)
Dental caries, a global oral health concern, is a biofilm-mediated disease. Streptococcus mutans, the most prevalent oral microbiota, produces extracellular enzymes, including glycosyltransferases responsible for sucrose polymerization. In bacterial communities, the biofilm matrix confers resistance to host immune responses and antibiotics. Thus, in cases of chronic dental caries, inhibiting bacterial biofilm assembly should prevent demineralization of tooth enamel, thereby preventing tooth decay. A high throughput screening was performed in the present study to identify small molecule inhibitors of S. mutans glycosyltransferases. Multiple pharmacophore models were developed, validated with multiple datasets, and used for virtual screening against large chemical databases. Over 3000 drug-like hits were obtained that were analyzed to explore their binding mode. Finally, six compounds that showed good binding affinities were further analyzed for ADME (absorption, distribution, metabolism, and excretion) properties. The obtained in silico hits were evaluated for in vitro biofilm formation. The compounds displayed excellent antibiofilm activities with minimum inhibitory concentration (MIC) values of 15.26–250 µg/mL. 相似文献
57.
Ragaa A. Hamouda Mervat H. Hussein Noura El-Ahmady El-Naggar Mohammed A. Karim-Eldeen Khalid H. Alamer Muneera A. Saleh Luluah M. Al Masoudi Eman M. Sharaf Reham M. Abd El-Azeem 《Molecules (Basel, Switzerland)》2022,27(4)
Seaweeds can play a vital role in plant growth promotion. Two concentrations (5 and 10 mg/mL) of soluble polysaccharides extracted from the green macroalgae Ulva fasciata and Ulva lactuca were tested on Zea mays L. The carbohydrate and protein contents, and antioxidant activities (phenols, ascorbic, peroxidase, and catalase) were measured, as well as the protein banding patterns. The soluble polysaccharides at 5 mg/mL had the greatest effect on the base of all of the parameters. The highest effects of soluble polysaccharides on the Zea mays were 38.453, 96.76, 4, 835, 1.658, 7.462, and 38615.19, mg/mL for carbohydrates, proteins, phenol, µg ascorbic/mL, mg peroxidase/g dry tissue, and units/g tissue of catalase, respectively. The total number of protein bands (as determined by SDS PAGE) was not changed, but the density of the bands was correlated to the treatments. The highest band density and promoting effect were correlated to 5 mg/mL soluble polysaccharide treatments extracted from Ulva fasciata in Zea mays, which can be used as a biofertilizer. 相似文献
58.
An easy,safe,solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide(C-200) in high yield within short span of time.All reactions were carried out just by grinding the two reactants in the presence of activated barium hydroxide(C-200). Results are also compared with sodium hydroxide and potassium hydroxide. 相似文献
59.
A new simple and sensitive spectrophotometric method for the determination of chromium(VI) is established. It relies upon the oxidation of iron(II) with the titled ion, in acidic medium, to form iron(III) which is complexed with tiron to form a stable blue color with maximum absorption at 650 nm. Adherence to Beer's law is observed in the range 10–100 μg of chromium(VI) per 25 ml, with a molar absorptivity of 5.6 × 103 liters mol?1 cm?1, sensitivity index of 0.0093 μg cm?1, relative error of ?5.0 to +0.3%, and relative standard deviation of 0.3–4.0%, depending on the concentration level. Furthermore, the reaction needs neither temperature control nor an extraction step. 相似文献
60.
Muhammad Sultan Hajira Tahir Khalid Ahmed Qazi Jahanzeb 《Frontiers of Chemistry in China》2011,6(2):105-112
The kinetics of the reaction of Fast Green dye (FG) with cetylpyridinum chloride was studied in alkaline medium by UV-Visible
spectrophotometer. Reduction of Fast Green dye was carried out by varying the fast green dye concentration, cetylpyridinum
chloride concentration and concentration of sodium hydroxide. In the present study the reduction of dye was carried out in
order to reduce the color content. The interaction of dye was carried out with reducing analyte (cetylpyridinum chloride).
The rate of the reaction was determined by varying the above parameters at different temperatures. It was observed that the
reduction followed pseudo first-order kinetics with respect to dye, surfactant, OH− ion concentration according to the following reaction pathway. The mechanism for the photo bleaching of the dye has been
proposed and well confirmed by the data simulation procedure. The activation parameters of the reaction like entropy of activation
(ΔS) and free energy of activation (ΔG) showed the extremely solvated states of transient complex which was less disorderly arranged than the oxidized form of dye,
whereas E
a
values reflects a high amount of energy required for the reduction of dye with cetylpyridinum chloride. 相似文献