首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   4231篇
  免费   201篇
  国内免费   32篇
化学   3205篇
晶体学   24篇
力学   116篇
数学   526篇
物理学   593篇
  2023年   37篇
  2022年   46篇
  2021年   79篇
  2020年   100篇
  2019年   102篇
  2018年   71篇
  2017年   57篇
  2016年   138篇
  2015年   121篇
  2014年   152篇
  2013年   227篇
  2012年   299篇
  2011年   366篇
  2010年   162篇
  2009年   131篇
  2008年   322篇
  2007年   315篇
  2006年   306篇
  2005年   253篇
  2004年   216篇
  2003年   192篇
  2002年   155篇
  2001年   34篇
  2000年   34篇
  1999年   37篇
  1998年   36篇
  1997年   41篇
  1996年   56篇
  1995年   31篇
  1994年   28篇
  1993年   24篇
  1992年   21篇
  1991年   25篇
  1990年   25篇
  1989年   13篇
  1988年   12篇
  1987年   12篇
  1986年   8篇
  1985年   22篇
  1984年   27篇
  1983年   11篇
  1982年   14篇
  1981年   13篇
  1980年   18篇
  1979年   10篇
  1978年   16篇
  1977年   12篇
  1976年   13篇
  1975年   8篇
  1974年   10篇
排序方式: 共有4464条查询结果,搜索用时 15 毫秒
921.
Thermoplastic composites were prepared using two continuous regenerated cellulose fiber types, rayon and lyocell, and with several different commercially-available thermoplastic cellulose esters as matrix. Matrix options included cellulose acetate propionate (CAP), and several cellulose acetate butyrates (CAB) with different butyryl content, having different molecular weights and different methods of plasticization (adipates and very low molecular weight cellulose ester fractions). Choice of cellulose ester type was generally found to have little or no effect on mechanical properties. A significant effect, however, was revealed for fiber type. The lyocell-based composites thereby were reflective of the greater stiffness of a fiber produced from anisotropic solution state. Their modulus consistently exceeded 20GPa whereas the rayon fiber-based composites had moduli between 6 and 8GPa. The latter, however, possessed failure strains that were 3 to 4 times greater than their stiffer counterparts.  相似文献   
922.
The structure of the title compound, C11H13NO3, is characterized by a two‐dimensional infinite network of intermolecular N—H?O and O—H?O hydrogen bonds.  相似文献   
923.
Microstructures for a cubic to orthorhombic transition are constructed using a geometrically nonlinear, thermoelastic theory of martensitic transformations. Such microstructures are of interest because they provide low energy paths along which a specimen can transform. The particular microstructures considered are the twinned martensite, austenite–martensite, wedge, triangle, and diamond. More specifically, all possible twins are found along with the corresponding twinning elements and magnitude of the twin shear. Further, two kinds of austenite–martensite microstructures are studied: those with a single variant of martensite and those with twinned martensite. The regions in the space of transformation stretches in which each of these microstructures exist are determined, and the shape strains and habit plane normals are found as well. In addition, special microstructures, the wedge, triangle, and diamond, are constructed with both the austenite-single variant and austenite-twinned martensite microstructures. These special microstructures are of interest because they provide a mechanism through which the transformation may proceed more easily, and they are possible only in alloys with particular transformation stretches. Numerically computed level curves in the space of the stretches are presented on which the special microstructures are possible. These results may be useful in providing guidelines for alloy design.  相似文献   
924.
The fermentation characteristics and effects of lignocelulosic toxic compounds on recombinant Zymomonas mobilis ZM4(pZB5), which is capable of converting both glucose and xylose to ethanol, and its parental strain, ZM4, were characterized using 13C and 31P nuclear magnetic resonance (NMR) in vivo. From the 31P NMR data, the levels of nucleoside triphosphates (NTP) of ZM(pZB5) using xylose were lower than those of glucose. This can be related to the intrinsically slower assimilation and/or metabolism of xylose compared to glucose and is evidence of a less energized state of ZM4(pZB5) cells during xylose fermentation. Acetic acid was shown to be strongly inhibitory to ZM4(pZB5) on xylose medium, with xylose utilization being completely inhibited at pH 5.0 or lower in the presence of 10.9 g/L of sodium acetate. From the 31P NMR results, the addition of sodium acetate caused decreased NTP and sugar phosphates, together with acidification of the cytoplasm. Intracellular deenergization and acidification appear to be the major mechanisms by which acetic acid exerts its toxic effects on this recombinant strain.  相似文献   
925.
926.
Summary: A novel non‐aqueous emulsion system, consisting of cyclohexane as the continuous and acetonitrile as the dispersed phase, is described. Stabilization of the system can be achieved by using polyisoprene‐block‐poly(methyl methacrylate) copolymers as emulsifiers. The suitability of this system for performing water‐sensitive, catalytic, and oxidative polymerizations and polycondensations is demonstrated by the synthesis of poly(3,4‐ethylenedioxythiophene), poly(thiophene‐3‐yl‐acetic acid), and polyacetylene. In all cases spherical nanoparticles with diameters as small as 23 nm can be obtained.

  相似文献   

927.
Summary: The equilibrium sorption and swelling behavior in supercritical CO2 of poly(D,L-lactic acid) and poly(lactic-co-glycolic acid) has been studied at a temperature of 35 °C and at pressures up to 200 bar. Sorption was measured through a gravimetric technique and swelling by visualization. From these data, the behavior of the different polymers can be compared. In terms of partial molar volume of CO2 in the polymer matrix, all the polymers exhibit a behavior typical of rubbery systems. The experimental results have been modeled using the Sanchez-Lacombe equation of state, which is able to represent the actual behavior of the polymer-CO2 systems with reasonable accuracy.  相似文献   
928.
In the title compound, Na+·H+·2C8H7O3, the anion contains a short Speakman-type hydrogen bond [O⃛O = 2.413 (2) Å]. The anions and the Na atoms lie across twofold axes.  相似文献   
929.
The functions of natural nucleic acids such as DNA and RNA have transcended genetic information carriers and now encompass affinity reagents, molecular catalysts, nanostructures, data storage, and many others. However, the vulnerability of natural nucleic acids to nuclease degradation and the lack of chemical functionality have imposed a significant constraint on their ever-expanding applications. Herein, we report the synthesis and polymerase recognition of a 5-(octa-1,7-diynyl)uracil 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) triphosphate. The DNA-templated, polymerase-mediated primer extension using this “click handle”-modified FANA (cmFANA) triphosphate and other FANA nucleotide triphosphates consisting of canonical nucleobases efficiently generated full-length products. The resulting cmFANA polymers exhibited excellent nuclease resistance and the ability to undergo efficient click conjugation with azide-functionalized molecules, thereby becoming a promising platform for serving as a programmable and evolvable synthetic genetic polymer capable of post-polymerization functionalization.

Polymerase-mediated incorporation of a “click handle”-modified fluoroarabinonucleic acid (cmFANA) triphosphate produces a new class of nuclease-resistant, evolvable genetic polymers that can be functionalized with azide-containing molecules.  相似文献   
930.
Limited tissue selectivity and targeting of anticancer therapeutics in systemic administration can produce harmful side effects in the body. Various polymer nano-vehicles have been developed to encapsulate therapeutics and prevent premature drug release. Dually responsive polymeric vesicles (polymersomes) assembled from temperature-/pH-sensitive block copolymers are particularly interesting for the delivery of encapsulated therapeutics to targeted tumors and inflamed tissues. We have previously demonstrated that temperature-responsive poly(N-vinylcaprolactam) (PVCL)-b-poly(dimethylsiloxane) (PDMS)-b-PVCL polymersomes exhibit high loading efficiency of anticancer therapeutics in physiological conditions. However, the in-vivo toxicity of these polymersomes as biocompatible materials has not yet been explored. Nevertheless, developing an advanced therapeutic nanocarrier must provide the knowledge of possible risks from the material’s toxicity to support its future clinical research in humans. Herein, we studied pH-induced degradation of PVCL10-b-PDMS65-b-PVCL10 vesicles in-situ and their dually (pH- and temperature-) responsive release of the anticancer drug, doxorubicin, using NMR, DLS, TEM, and absorbance spectroscopy. The toxic potential of the polymersomes was evaluated in-vivo by intravenous injection (40 mg kg−1 single dose) of PVCL10-PDMS65-PVCL10 vesicles to mice. The sub-acute toxicity study (14 days) included gravimetric, histological, and hematological analyses and provided evidence for good biocompatibility and non-toxicity of the biomaterial. These results show the potential of these vesicles to be used in clinical research.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号