Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity

Pyroptosis is a programmed cell death widely studied in cancer cells for tumour inhibition, but rarely in dendritic cell (DC) activation for vaccine development. Here, we report the synthesis of sodium stabilized mesoporous aluminosilicate nanoparticles as DC pyroptosis modulators and antigen carriers. By surface modification of sodium-stabilized four-coordinate aluminium species on dendritic mesoporous silica nanoparticles, the resultant Na-^IVAl-DMSN significantly activated DC through caspase-1 dependent pyroptosis via pH responsive intracellular ion exchange. The released proinflammatory cellular contents further mediated DC hyperactivation with prolonged cytokine release. In vivo studies showed that Na-^IVAl-DMSN induced enhanced cellular immunity mediated by natural killer (NK) cells, cytotoxic T cells, and memory T cells as well as humoral immune response. Our results provide a new principle for the design of next-generation nanoadjuvants for vaccine applications.

Na-^IVAl-DMSN acts as both antigen carriers and modulators to “hyperactivate” dendritic cells (DCs) via potassium (K⁺) efflux dependent pyroptosis, eventually leading to enhanced adaptive and innate immunity.     

Three-dimensional architectures based on carbon nanotube bridged Ti2C MXene nanosheets for Li-S batteries

Lithium-sulfur(Li-S)batteries are promising candidates for high density electrochemical energy storage systems.However,the poor conductivity of S and the shuttl...     

用光学多道分析器测定RH的不确定度评定

本文使用光学多道分析器测定了氢原子光谱的计Hα、Hβ、Hγ、Hδ,谱线波长,利用最小二乘法处理测量数据：建立了测量数学模型,得到氢原子光谱里德伯常量RH,按国家计量技术规范JJF1059—1999标准对测量的不确定度进行了分析与评定。     

Luminescence interference-free lifetime nanothermometry pinpoints in vivo temperature

Luminescence nanothermometry makes non-invasive and real-time temperature readings possible in living animals. However,the spectral fluctuation in tissues and fluids, as well as the interaction between fluorophores and environment hinders accuracy of the thermometry. Here, we report a luminescence lifetime-based nanothermometry which specifically addresses this problem. A temporal based calibration(lifetime sensing) in the NIR range, an endogenous thermal response as well as a polymer encapsulation evading environmental factors, altogether help to pinpoint temperature in vivo. Thanks to the highly condensed NdYb ions in a well-protected tiny core-shell nanocrystal(overall 11 nm), a temperature sensitivity about 2.07% K~(-1)(with 5% Yb~(3+) doped nanoparticles) and an accuracy of 0.27 K(with 25% Yb~(3+) doped nanoparticles) in biological fluids are achieved.Hopefully, combining thermally activated energy transfer nanothermometer with anti-interference lifetime thermometry would provide a more accurate temperature measurement for biological and preclinical studies.     

1D atom localization via probe absorption spectrum in a four-level cascade-type atomic system

We present a simple scheme of atom localization in a subwavelength domain via manipulation of probe absorption spectrum in a four-level atomic system. Due to the joint quantum interference induced by the standing-wave and radio-frequency driving fields, the localization peak position and number as well as the conditional position probability can be controlled by properly adjusting the system parameters. The proposed scheme may provide a promising way to achieve high-precision and high-resolution 1D atom localization.     

Near-infrared photonic crystals with higher-order bandgaps generated by two-photon photopolymerization

Three-dimensional photonic crystals with bandgaps of 1.5-2.3 mum in wavelength and with gap/midgap ratios of as much as 18% were generated efficiently by two-photon photopolymerization in a liquid resin. From 0.5-1.1-mW femtosecond-pulsed 540-nm light, woodpile structures consisting of 40 layers of elliptically shaped rods spaced at 350-500 nm were fabricated by focusing with a 1.3-N.A. objective. The high degree of correlation in these structures allowed the suppression of infrared transmission by as much as 50% as well as the observation of higher-order bandgaps. We also investigated the decrease in the gap wavelength on reduction of layer spacing, in-plane rod spacing, and rod size.     

Highly simplified device for ultrashort-pulse measurement

We show that a frequency-resolved optical gating device using (1) a thick nonlinear crystal to replace the usual thin crystal and spectrometer and (2) a Fresnel biprism to replace the beam splitter and delay line yields a remarkably simple single-shot ultrashort-pulse intensity-and-phase measurement device with no sensitive alignment parameters and significantly greater sensitivity.     

<Emphasis Type="Italic">Cis</Emphasis>/<Emphasis Type="Italic">trans</Emphasis> Fluorescent Recognition by Naphthalimide Dyes ⊂ CB [7] Assembly

A novel method to recognize cis/trans isomers was studied here. The naphthalimide dye as guest could bind with host cucurbit [7]uril (CB [7]) and 1:1 naphthalimide dye ? CB [7] assembly was formed. Moreover, this assembly was used as a fluorescent probe to recognized Fumaric acid (FA) and maleic acid (MA) via fluorescence titration. Two carboxyls in MA are in the same side, they could form stable interaction with the assembly and the fluorescence intensity decreased obviously when naphthalimide dye ? CB [7] was titrated by MA (nearly quenched in 1.5 equiv). But two carboxyls in FA are in opposite sides, the interaction between FA and the assembly was weak and not stable, and the fluorescence intensity changed inconspicuously when the assembly was titrated by FA.     

Electronic band structure of a type-II ’W’ quantum well calculated by an eight-band k·p model

In this paper, we present an investigation of type-II 'W' quantum wells for the InAs/Ga_1-xIn_xSb/AlSb family, where 'W' denotes the conduction profile of the material. We focus our attention on using the eight-band k?p model to calculate the band structures within the framework of finite element method. For the sake of clarity, the simulation in this paper is simplified and based on only one period---AlSb/InAs/Ga_1-xIn_xSb/InAs/AlSb. The obtained numerical results include the energy levels and wavefunctions of carriers. We discuss the variations of the electronic properties by changing several important parameters, such as the thickness of either InAs or Ga_1-xIn_xSb layer and the alloy composition in Ga_1-xIn_xSb separately. In the last part, in order to compare the eight-band k?p model, we recalculate the conduction bands of the 'W' structure using the one-band k?p model and then discuss the difference between the two results, showing that conduction bands are strongly coupled with valence bands in the narrow band gap structure. The in-plane energy dispersions, which illustrate the suppression of the Auger recombination process, are also obtained.     

Optical spin-dependent angular shift in structured metamaterials

The physics behind the spin (polarization)-dependent electromagnetic hot-spot phenomenon is due to the presence of the geometric phase resulting from the optical spin-orbit interaction in the interaction of light with the subwavelength microstructures. Unlike the tiny spin-dependent shift of light associated with the usual spin-Hall effect of light, here we present the distinct polarization-dependent angular shift by employing an array of subwavelength metallic apertures. More importantly, this novel electromagnetic precession is accompanied by the extraordinary optical transmission phenomenon and offers the exciting possibilities for novel applications for subwavelength structured metallic systems.