Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

Rutin (R) and quercetin (Q) are two widespread dietary flavonoids. Previous studies regarding the plasma cholesterol-lowering activity of R and Q generated inconsistent results. The present study was therefore carried out to investigate the effects of R and Q on cholesterol metabolism in both HepG2 cells and hypercholesterolemia hamsters. Results from HepG2 cell experiments demonstrate that both R and Q decreased cholesterol at doses of 5 and 10 µM. R and Q up-regulated both the mRNA and protein expression of sterol regulatory element binding protein 2 (SREBP2), low-density lipoprotein receptor (LDLR), and liver X receptor alpha (LXRα). The immunofluorescence study revealed that R and Q increased the LDLR expression, while only Q improved LDL-C uptake in HepG2 cells. Results from hypercholesterolemia hamsters fed diets containing R (5.5 g/kg diet) and Q (2.5 g/kg diet) for 8 weeks demonstrate that both R and Q had no effect on plasma total cholesterol. In the liver, only Q reduced cholesterol significantly. The discrepancy between the in vitro and in vivo studies was probably due to a poor bioavailability of flavonoids in the intestine. It was therefore concluded that R and Q were effective in reducing cholesterol in HepG2 cells in vitro, whereas in vivo, the oral administration of the two flavonoids had little effect on plasma cholesterol in hamsters.     

Nonflammable nonaqueous electrolytes for lithium batteries

As the energy density of state-of-the-art lithium (Li)-ion batteries (LIBs) increases, the safety concern of LIBs using liquid electrolytes is drawing increasing attention. Flammability of electrolytes is a critical link of the overall safety performance of LIBs and Li metal batteries. For this reason, intensive efforts have been devoted to suppressing the flammability of liquid electrolytes. In this short review, the common approaches to reduce the flammability of the nonaqueous liquid electrolytes will be summarized. The advantages and limitations of these approaches will also be discussed.     

Adsorption and separation behavior of strontium and yttrium using a silica-based bis(2-ethylhexyl) hydrogen phosphate adsorbent

Journal of Radioanalytical and Nuclear Chemistry - (HDEHP?+?Hexa)/SiO2-P, a silica-based adsorbent, was prepared and used to separate Y(III) from a mixed solution of Sr(II) and Y(III)....     

A copper-based coordination polymer formed through synergistic bridging of 1,2,4-triazole and acetate anions: synthesis,crystal structure and magnetic properties

Transition Metal Chemistry - A Cu(II) coordination polymer, [Cu2(pztrz)2(μ-CH3COO)(CH3COO)]·3H2O (1), derived from mono-substituted 1,2,4-triazole derivative 3-(pyrazinyl)-1,2,4-triazole...     

TheL 2 squeezing property for nonlinear bipolar viscous fluids

A squeezing property inL ²() is established for orbits of the semigroup associated with the equations of motion of a nonlinear incompressible bipolar viscous fluid; it is assumed that=[0,L] ⁿ ,n=2 or 3,L>0, and that the velocity vector satisfies a spatial periodicity condition. The proof depends, in an essential manner, on key estimates for both the nonlinear operator generated by the nonlinear viscosity term in the model and the time integral of theH ³() norm of the velocity.     

DIRECT NUMERICAL SIMULATIONS ON THE TURBULENT FLOW PAST A CONFINED CIRCULAR CYLINDER WITH THE INFLUENCE OF THE STREAMWISE MAGNETIC FIELDS1)

绕流是托卡马克装置中液态包层内常见的流动形态,对流场与热量分布有着重要的影响.本文通过直接数值模拟(DNS),研究了不同磁场强度下$Re=3900$的圆柱绕流,分析了磁场强度对于湍流尾迹的影响.无磁场情况下,直接数值模拟的结果与前人的实验及模拟结果吻合很好.圆柱下游的尾迹中,随着流向距离的增大, 流向速度剖面逐渐从U型进化呈V型, 并慢慢趋于平缓,这表明尾迹中的流动结构受圆柱影响逐渐减小.圆柱后方两侧的剪切层中,由于Kelvin-Helmholtz不稳定性的影响,可以清晰地看到小尺度剪切层涡的脱落.通过对无磁场的计算结果施加流向磁场,本文计算了哈特曼数($Ha$)分别为20, 40和80的工况,以研究磁场效应对于湍流的影响.结果表明磁场较弱时,流动依然呈三维湍流状态.随着磁场增强, 近圆柱尾流区受磁场抑制明显,回流区被拉长,剪切层失稳位置向下游转移.圆柱后方的涡结构由于受到竖直方向洛伦兹力的挤压作用,随着哈特曼数的增加尾迹区域逐渐变窄.相比于无磁场情况的涡结构,由于磁场的耗散作用,相应的涡结构尺度变小.该研究不仅扩展了现有磁场下湍流运动的参数范围,对于液态包层的设计及安全运行同样具有重要的理论指导意义和工程应用价值.     

Two Families of Entanglement-Assisted Quantum MDS Codes from Cyclic Codes

International Journal of Theoretical Physics - With entanglement-assisted (EA) formalism, arbitrary classical linear codes are allowed to transform into EAQECCs by using pre-shared entanglement...     

Layer-by-layer assembly of multilayer optical lattices: A theoretical proposal

The European Physical Journal D - This paper describes the verification and validation (V&V) framework developed for the stochastic Particle-in-Cell, Direct Simulation Monte Carlo code...     

Effects of Fatty Alcohols with Different Chain Lengths on the Performance of Low pH Biomass-Based Foams for Radioactive Decontamination

Compared with polymers and nanoparticles, fatty alcohols can not only increase the stability of foam, but also maintain better foamability at pH < 2, which is beneficial to reduce waste liquid and increase decontamination efficiency for radioactive surface pollution. However, different fatty alcohols have different hydrophobic chain lengths. The effects of fatty alcohols with different chain lengths on the performance of decontamination foam were studied at pH < 2, to assist in the selection of suitable fatty alcohols as foam stabilizers. Combined with betaine surfactant and phytic acid, biomass-based foams were synthesized using fatty alcohols with different chain lengths. When the hydrophobic tail groups of the fatty alcohol and the surfactant were the same, the foam showed the best performance, including the lowest surface tension, the highest liquid film strength, the greatest sag-resistance and the best stability. However, when the hydrophobic tail groups were different, the space between adjacent surface active molecules was increased by thermal motion of the excess terminal tail segments (a tail-wagging effect), and the adsorption density reduced on the gas-liquid interface, leading to increased surface tension and decreased liquid film strength, sag-resistance and stability. The use of decontamination foam stabilized by fatty alcohols with the same hydrophobic group as the surfactant was found to increase the decontamination rate of radioactive uranium pollution from 64 to over 90% on a vertical surface.