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131.
AR Wilmsmeyer J Uzarski PJ Barrie JR Morris 《Langmuir : the ACS journal of surfaces and colloids》2012,28(30):10962-10967
The fundamental interactions of dimethyl methylphosphonate (DMMP) and dimethyl chlorophosphate (DMCP) on amorphous silica nanoparticles have been investigated with transmission infrared spectroscopy and temperature-programmed desorption (TPD). DMMP and DMCP both adsorb molecularly to silica through the formation of hydrogen bonds between isolated silanols and the phosphoryl oxygen of the adsorbate. The magnitude of the shift of the ν(OH) mode upon simulant adsorption is correlated to the adsorption strength. The activation energies for desorption for a single DMMP or DMCP molecule from amorphous silica varied with coverage. In the limit of zero coverage, after the effects of defects were excluded, the activation energies were 54.5 ± 0.3 and 48.4 ± 1.0 kJ/mol for DMMP and DMCP, respectively. 相似文献
132.
133.
Christopher J. Burns Robert D. Groneberg Joseph M. Salvino Gerard McGeehan Stephen M. Condon Robert Morris Matthew Morrissette Rose Mathew Shelley Darnbrough Kent Neuenschwander Anthony Scotese Stevan W. Djuric John Ullrich Richard Labaudiniere 《Angewandte Chemie (International ed. in English)》1998,37(20):2848-2850
One common synthetic route creates small-molecule libraries directed toward two functionally distinct target families. The novel structural template 1 can independently display the necessary pharmacophore patterns for inhibition of members of two different biomolecular target families, the matrix metalloproteinases (MMPs) or the phosphodiesterases (PDEs). The incorporation of multiple target family directed design elements into combinatorial library design could help expedite the pharmaceutical lead discovery process. Z=OR′ (PDE4), H (MMPs). 相似文献
134.
Potyrailo RA Chisholm BJ Morris WG Cawse JN Flanagan WP Hassib L Molaison CA Ezbiansky K Medford G Reitz H 《Journal of combinatorial chemistry》2003,5(4):472-478
Coupling of combinatorial chemistry methods with high-throughput (HT) performance testing and measurements of resulting properties has provided a powerful set of tools for the 10-fold accelerated discovery of new high-performance coating materials for automotive applications. Our approach replaces labor-intensive steps with automated systems for evaluation of adhesion of 8 x 6 arrays of coating elements that are discretely deposited on a single 9 x 12 cm plastic substrate. Performance of coatings is evaluated with respect to their resistance to adhesion loss, because this parameter is one of the primary considerations in end-use automotive applications. Our HT adhesion evaluation provides previously unavailable capabilities of high speed and reproducibility of testing by using a robotic automation, an expanded range of types of tested coatings by using the coating tagging strategy, and an improved quantitation by using high signal-to-noise automatic imaging. Upon testing, the coatings undergo changes that are impossible to quantitatively predict using existing knowledge. Using our HT methodology, we have developed several coatings leads. These HT screening results for the best coating compositions have been validated on the traditional scales of coating formulation and adhesion loss testing. These validation results have confirmed the superb performance of combinatorially developed coatings over conventional coatings on the traditional scale. 相似文献
135.
One of the major techniques used for the method development of ternary and quaternary high performance liquid chromatography (HPLC) systems has been to use mixture designs, often referred to as "Glajch's Triangle". This technique does not allow for the systematic and simultaneous optimization of other factors such as gradient time, pH and temperature that affect the quality of separations. An alternative approach is to use experimental designs. The condition, however, that the composition of all components of the mobile phase must total 100% presents a problem when trying to mathematically represent ranges of each mobile phase constituent of a ternary or quaternary system. A method is described here, based on spherical coordinate representations, that adheres to the constraints of the mobile phase composition and allows experimental designs, such as central composite and factorial designs, to be applied to the simultaneous optimization of the mobile phase composition. Other factors, in particular temperature and gradient time, can then be included in the design. As a result of applying these designs to the HPLC separation of phenols and corticosteroids, it was found necessary to include three-way interactions between experimental factors in the model. The significance of these interactions shows that they need to be considered in HPLC method development. 相似文献
136.
T. A. Nichols J. S. Morris V. L. Spate C. J. Tharp C. K. Baskett T. L. Horsman M. M. Mason T. P. Cheng 《Journal of Radioanalytical and Nuclear Chemistry》1998,235(1-2):65-69
A global radionuclide monitoring system is being engineered as part of a multi-technology verification system for the Comprehensive
Nuclear Test Ban Treaty. The system detects airborne radioactive aerosols and gases that can indicate nuclear weapons test
debris. The backbone of the system is a network of 80 remote detection stations that utilize high-volume air sampling and
high-resolution gamma spectrometry to provide in-situ assay and near-real time reporting. These stations are linked to the
International Data Centre, which is a central data processing hub where raw spectral data is automatically processed, analyzed,
and disseminated to the states parties. Measurements are categorized based on spectral content to determine which contain
anomalous anthropogenic radionuclides that require intensive radiochemical analysis at a certified laboratory. The resulting
system has the capability to measure microbecquerel concentrations of radionuclides and provide accessible data products within
minutes of field measurements. During the past year of international operations, the minimum detectable concentrations and
spectroscopy processing statistics were recorded as a function of geographical location and time. The results show that this
system is an effective tool for nuclear test monitoring, as well as other applications such as radiological emergency response,
public health monitoring, and scientific research. 相似文献
137.
138.
Dr. Paul S. Wheatley Dr. Pavla Chlubná‐Eliášová Dr. Heather Greer Prof. Wuzong Zhou Dr. Valerie R. Seymour Dr. Daniel M. Dawson Prof. Sharon E. Ashbrook Dr. Ana B. Pinar Dr. Lynne B. McCusker Dr. Maksym Opanasenko Prof. Jiří Čejka Prof. Russell E. Morris 《Angewandte Chemie (International ed. in English)》2014,53(48):13210-13214
Zeolites are important materials whose utility in industry depends on the nature of their porous structure. Control over microporosity is therefore a vitally important target. Unfortunately, traditional methods for controlling porosity, in particular the use of organic structure‐directing agents, are relatively coarse and provide almost no opportunity to tune the porosity as required. Here we show how zeolites with a continuously tuneable surface area and micropore volume over a wide range can be prepared. This means that a particular surface area or micropore volume can be precisely tuned. The range of porosity we can target covers the whole range of useful zeolite porosity: from small pores consisting of 8‐rings all the way to extra‐large pores consisting of 14‐rings. 相似文献
139.
The Assembly‐Disassembly‐Organization‐Reassembly Mechanism for 3D‐2D‐3D Transformation of Germanosilicate IWW Zeolite 下载免费PDF全文
Pavla Chlubná‐Eliášová Yuyang Tian Dr. Ana B. Pinar Dr. Martin Kubů Prof. Jiří Čejka Prof. Russell E. Morris 《Angewandte Chemie (International ed. in English)》2014,53(27):7048-7052
Hydrolysis of germanosilicate zeolites with the IWW structure shows two different outcomes depending on the composition of the starting materials. Ge‐rich IWW (Si/Ge=3.1) is disassembled into a layered material (IPC‐5P), which can be reassembled into an almost pure silica IWW on treatment with diethoxydimethylsilane. Ge‐poor IWW (Si/Ge=6.4) is not completely disassembled on hydrolysis, but retains some 3D connectivity. This structure can be reassembled into IWW by incorporation of Al to fill the defects left when the Ge is removed. 相似文献
140.
Raman spectroscopy provides information on bone chemical composition and structure via widely used metrics including mineral to matrix ratio, mineral crystallinity and carbonate content, collagen crosslinking ratio and depolarization ratios. These metrics are correlated with bone material properties, such as hardness, plasticity and Young''s modulus. We review application of Raman spectroscopy to two important irradiated animalmodels: the mouse tibia, amodel for damage to cortical bone sites including the rib (breast cancer) and to healthy tissue adjacent to extremity sarcomas, and the rat mandible, a model for radiation damage in head and neck cancer radiotherapy. Longitudinal studies of irradiated mouse tibia demonstrate that radiation-induced matrix abnormalities can persist even 26 weeks postradiation. Polarized Raman spectroscopy shows formation of more ordered orientation of both mineral and collagen. At 8 weeks post-radiation, irradiated rat hemimandible exhibits transient hypermineralization, increased collagen cross-linking and decreased depolarization ratios of mineral and collagen. A standard radioprotectant, amifostine, mitigates rat mandible radiation damage, with none remaining detectable 18 weeks post-radiation. Already a powerful tool to monitor radiation damage, Raman spectroscopy may be important in development of new radiotherapy protocols and radioprotective agents. Further in vivo studies of radiation effects on the rodent models are underway, as are development of methodologies for eventual use in human subjects. 相似文献