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991.
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993.
Inside Cover: Molecularly Defined Nanostructures Based on a Novel AAA–DDD Triple Hydrogen‐Bonding Motif (Angew. Chem. Int. Ed. 5/2016)
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994.
Enhancing the Sensitivity of CPMG Relaxation Dispersion to Conformational Exchange Processes by Multiple‐Quantum Spectroscopy
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Dr. Tairan Yuwen Dr. Pramodh Vallurupalli Prof. Lewis E. Kay 《Angewandte Chemie (International ed. in English)》2016,55(38):11490-11494
A triple‐quantum 1H Carr–Purcell–Meiboom–Gill NMR relaxation dispersion experiment is presented that uses methyl group probes as reporters of conformational exchange in highly deuterated, methyl‐protonated proteins. Significantly larger dispersion profiles, by as much as a factor of nine, can be obtained relative to single‐quantum approaches, thus offering very significant advantages in applications involving interconverting conformers with only small changes in structure or in studies of rare states that are at very low populations. Applications to a number of protein systems are presented where the utility of the method, including its improved sensitivity to chemical exchange processes, is established. 相似文献
995.
Dong Long Frank Delaglio Ashok Sekhar Lewis E. Kay 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(36):10653-10657
Chemical exchange saturation transfer (CEST) NMR spectroscopy is a powerful tool for studies of slow timescale protein dynamics. Typical experiments are based on recording a large number of 2D data sets and quantifying peak intensities in each of the resulting planes. A weakness of the method is that peaks must be resolved in 2D spectra, limiting applications to relatively small proteins. Resolution is significantly improved in 3D spectra but recording uniformly sampled data is time‐prohibitive. Here we describe non‐uniformly sampled HNCO‐based pseudo‐4D CEST that provides excellent resolution in reasonable measurement times. Data analysis is done through fitting in the time domain, without the need of reconstructing the frequency dimensions, exploiting previously measured accurate peak positions in reference spectra. The methodology is demonstrated on several protein systems, including a nascent form of superoxide dismutase that is implicated in neurodegenerative disease. 相似文献
996.
Reversible Control of Nanoparticle Functionalization and Physicochemical Properties by Dynamic Covalent Exchange
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Flavio della Sala Dr. Euan R. Kay 《Angewandte Chemie (International ed. in English)》2015,54(14):4187-4191
Existing methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide‐based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non‐biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle‐bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface‐bound species, and real‐time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching—and subtly tuning—NP properties such as solvophilicity. 相似文献
997.
Dendritic Domains with Hexagonal Symmetry Formed by X‐Shaped Bolapolyphiles in Lipid Membranes
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Stefan Werner Dr. Helgard Ebert Bob‐Dan Lechner Frank Lange Anja Achilles Ruth Bärenwald Silvio Poppe Prof. Dr. Alfred Blume Prof. Dr. Kay Saalwächter Prof. Dr. Carsten Tschierske Prof. Dr. Kirsten Bacia 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(24):8840-8850
A novel class of bolapolyphile (BP) molecules are shown to integrate into phospholipid bilayers and self‐assemble into unique sixfold symmetric domains of snowflake‐like dendritic shapes. The BPs comprise three philicities: a lipophilic, rigid, π–π stacking core; two flexible lipophilic side chains; and two hydrophilic, hydrogen‐bonding head groups. Confocal microscopy, differential scanning calorimetry, XRD, and solid‐state NMR spectroscopy confirm BP‐rich domains with transmembrane‐oriented BPs and three to four lipid molecules per BP. Both species remain well organized even above the main 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine transition. The BP molecules only dissolve in the fluid membrane above 70 °C. Structural variations of the BP demonstrate that head‐group hydrogen bonding is a prerequisite for domain formation. Independent of the head group, the BPs reduce membrane corrugation. In conclusion, the BPs form nanofilaments by π stacking of aromatic cores, which reduce membrane corrugation and possibly fuse into a hexagonal network in the dendritic domains. 相似文献
998.
Kay Yeung Rebecca E. Ruscoe James Rae Alexander P. Pulis David J. Procter 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2016,128(39):12091-12095
A highly enantio‐ and diastereoselective copper‐catalyzed three‐component coupling affords the first general synthesis of homoallylic amines bearing adjacent stereocenters from achiral starting materials. The method utilizes a commercially available NHC ligand and copper source, operates at ambient temperature, couples readily available simple imines, allenes, and diboranes, and yields high‐value homoallylic amines that exhibit versatile amino, alkenyl, and boryl units. 相似文献
999.
A proficiency testing programme might involve a great number of participating laboratories coming from different countries or regions, and normally they analysed the same test materials using their own routine analytical methods. Hence, the results of a proficiency testing programme may contain valuable information which could serve purposes other than just performance evaluation. This study attempted to extract information from the results of a proficiency testing programme for the purposes of educating the participating laboratories as suggested by ISO/IEC 17043. The “bias analysis” approach introduced in this study was based on the statistical model of measurement and the nature of bias in chemical analysis. With this approach, the participating laboratories could estimate the bias associated with different settings of experimental conditions according to the statistics of subset distribution of the reported results from the participating laboratories. This would be useful for them to review the analytical procedures they used and modify their methods if needed. The approach was applied to the analysis of data obtained from a number of past proficiency testing programmes, and the findings were discussed in this paper. 相似文献
1000.
OBJECTIVE: The short-term impact of the pre-symptomatic genetic test (PT) for Machado-Joseph disease (MJD) in the Azores (Portuguese Islands) was assessed in 46 individuals at risk who completed the PT Program. METHODS: Scores for depression and anxiety were used as indicators of the subjects' emotional status immediately before the PT and 1 year after disclosure of the results. RESULTS: Global levels of participation in the Azorean PT Program for MJD were high (20.7%), particularly in Flores Island (35.8%). For the total sample, mean scores of depression and anxiety before and after the PT presented without clinical significance. No differences were found for depression and anxiety scores before and after the PT. Furthermore, when grouped by test results (carriers/non-carriers), there were no differences between pre- and post-test levels. CONCLUSIONS: Results indicate that the test result did not cause a decrease in the psychological well-being of the individuals tested. The high number of participants performing the PT in the small and isolated community of Flores Island, where MJD represents a source of stigma, was interpreted as an indication that in this particular population the PT offers the individuals at risk the possibility of liberating from a stigma, and, hence, from exclusion. 相似文献