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71.
[reaction: see text] A stepwise formal [3 + 3] cycloaddition sequence via a Grignard addition-cyclization reaction leads to a much improved piperidine synthesis. This methodology provides improved flexibility in both the aziridine substrate and TMM equivalent. 相似文献
72.
Short‐Range Order of Methylammonium and Persistence of Distortion at the Local Scale in MAPbBr3 Hybrid Perovskite 下载免费PDF全文
Dr. Katharine Page Dr. Joan E. Siewenie Prof. Paolo Quadrelli Prof. Lorenzo Malavasi 《Angewandte Chemie (International ed. in English)》2016,55(46):14320-14324
Short‐range investigation by means of variable‐temperature neutron total scattering and pair distribution function analysis revealed that the local environment around the methylammonium (MA) cation in MAPbBr3 hybrid perovskite is maintained through the different phase transitions observed as a function of temperature. In addition, the orthorhombic distortion of the lattice is present at any temperature. Local structure around MA changes from static to configurationally averaged or dynamic with temperature but the local structure of the low‐temperature orthorhombic phase is preserved. 相似文献
73.
Smith MB Page K Siegrist T Redmond PL Walter EC Seshadri R Brus LE Steigerwald ML 《Journal of the American Chemical Society》2008,130(22):6955-6963
We have investigated the paraelectric-to-ferroelectric phase transition of various sizes of nanocrystalline barium titanate (BaTiO3) by using temperature-dependent Raman spectroscopy and powder X-ray diffraction (XRD). Synchrotron X-ray scattering has been used to elucidate the room temperature structures of particles of different sizes by using both Rietveld refinement and pair distribution function (PDF) analysis. We observe the ferroelectric tetragonal phase even for the smallest particles at 26 nm. By using temperature-dependent Raman spectroscopy and XRD, we find that the phase transition is diffuse in temperature for the smaller particles, in contrast to the sharp transition that is found for the bulk sample. However, the actual transition temperature is almost unchanged. Rietveld and PDF analyses suggest increased distortions with decreasing particle size, albeit in conjunction with a tendency to a cubic average structure. These results suggest that although structural distortions are robust to changes in particle size, what is affected is the coherency of the distortions, which is decreased in the smaller particles. 相似文献
74.
Katharine Turner 《Foundations of Computational Mathematics》2013,13(6):913-933
A standard reconstruction problem is how to discover a compact set from a noisy point cloud that approximates it. A finite point cloud is a compact set. This paper proves a reconstruction theorem which gives a sufficient condition, as a bound on the Hausdorff distance between two compact sets, for when certain offsets of these two sets are homotopic in terms of the absence of μ-critical points in an annular region. We reduce the problem of reconstructing a subset from a point cloud to the existence of a deformation retraction from the offset of the subset to the subset itself. The ambient space can be any Riemannian manifold but we focus on ambient manifolds which have nowhere negative curvature (this includes Euclidean space). We get an improvement on previous bounds for the case where the ambient space is Euclidean whenever μ≤0.945 (μ∈(0,1) by definition). In the process, we prove stability theorems for μ-critical points when the ambient space is a manifold. 相似文献
75.
Sheridan RP Maiorov VN Holloway MK Cornell WD Gao YD 《Journal of chemical information and modeling》2010,50(11):2029-2040
One approach to estimating the "chemical tractability" of a candidate protein target where we know the atomic resolution structure is to examine the physical properties of potential binding sites. A number of other workers have addressed this issue. We characterize ~290,000 "pockets" from ~42,000 protein crystal structures in terms of a three parameter "pocket space": volume, buriedness, and hydrophobicity. A metric DLID (drug-like density) measures how likely a pocket is to bind a drug-like molecule. This is calculated from the count of other pockets in its local neighborhood in pocket space that contain drug-like cocrystallized ligands and the count of total pockets in the neighborhood. Surprisingly, despite being defined locally, a global trend in DLID can be predicted by a simple linear regression on log(volume), buriedness, and hydrophobicity. Two levels of simplification are necessary to relate the DLID of individual pockets to "targets": taking the best DLID per Protein Data Bank (PDB) entry (because any given crystal structure can have many pockets), and taking the median DLID over all PDB entries for the same target (because different crystal structures of the same protein can vary because of artifacts and real conformational changes). We can show that median DLIDs for targets that are detectably homologous in sequence are reasonably similar and that median DLIDs correlate with the "druggability" estimate of Cheng et al. (Nature Biotechnology 2007, 25, 71-75). 相似文献
76.
An Fe(III)/NaBH(4)-mediated reaction for the functionalization of unactivated alkenes is described defining the alkene substrate scope, establishing the exclusive Markovnikov addition, exploring a range of free radical traps, examining the Fe(III) salt and initiating hydride source, introducing H(2)O-cosolvent mixtures, and exploring catalytic variants. Its use led to the preparation of a novel, potent, and previously inaccessible C20'-vinblastine analogue. 相似文献
77.
78.
This paper studies the scattering of electromagnetic waves from a (local) perturbation of a fixed surface, the boundary of a given obstacle in ?3. The goal is to produce an algorithm for solving boundary value problems in the exterior of the perturbed domain solely based on the knowledge of the Green function for the original surface. This is done by solving a boundary integral equation which only involves the perturbed portion of the boundary. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
79.
Prokop KA Neu HM de Visser SP Goldberg DP 《Journal of the American Chemical Society》2011,133(40):15874-15877
One-electron oxidation of Mn(V)-oxo corrolazine 2 affords 2(+), the first example of a Mn(V)(O) π-cation radical porphyrinoid complex, which was characterized by UV-vis, EPR, LDI-MS, and DFT methods. Access to 2 and 2(+) allowed for a direct comparison of their reactivities in oxygen-atom transfer (OAT) reactions. Both complexes are capable of OAT to PPh(3) and RSR substrates, and 2(+) was found to be a more potent oxidant than 2. Analysis of rate constants and activation parameters, together with DFT calculations, points to a concerted OAT mechanism for 2(+) and 2 and indicates that the greater electrophilicity of 2(+) likely plays a dominant role in enhancing its reactivity. These results are relevant to comparisons between Compound I and Compound II in heme enzymes. 相似文献
80.
Fukuzumi S Kotani H Prokop KA Goldberg DP 《Journal of the American Chemical Society》2011,133(6):1859-1869
The electron-transfer and hydride-transfer properties of an isolated manganese(V)?oxo complex, (TBP8Cz)Mn(V)(O) (1) (TBP8Cz = octa-tert-butylphenylcorrolazinato) were determined by spectroscopic and kinetic methods. The manganese(V)?oxo complex 1 reacts rapidly with a series of ferrocene derivatives ([Fe(C5H4Me)2], [Fe(C5HMe4)2], and ([Fe(C5Me5)2] = Fc*) to give the direct formation of [(TBP8Cz)Mn(III)(OH)]? ([2-OH]?), a two-electron-reduced product. The stoichiometry of these electron-transfer reactions was found to be (Fc derivative)/1 = 2:1 by spectral titration. The rate constants of electron transfer from ferrocene derivatives to 1 at room temperature in benzonitrile were obtained, and the successful application of Marcus theory allowed for the determination of the reorganization energies (λ) of electron transfer. The λ values of electron transfer from the ferrocene derivatives to 1 are lower than those reported for a manganese(IV)?oxo porphyrin. The presumed one-electron-reduced intermediate, a Mn(IV) complex, was not observed during the reduction of 1. However, a Mn(IV) complex was successfully generated via one-electron oxidation of the Mn(III) precursor complex 2 to give [(TBP8Cz)Mn(IV)]+ (3). Complex 3 exhibits a characteristic absorption band at λ(max) = 722 nm and an EPR spectrum at 15 K with g(max)′ = 4.68, g(mid)′ = 3.28, and g(min)′ = 1.94, with well-resolved 55Mn hyperfine coupling, indicative of a d3 Mn(IV)S = 3/2 ground state. Although electron transfer from [Fe(C5H4Me)2] to 1 is endergonic (uphill), two-electron reduction of 1 is made possible in the presence of proton donors (e.g., CH3CO2H, CF3CH2OH, and CH3OH). In the case of CH3CO2H, saturation behavior for the rate constants of electron transfer (k(et)) versus acid concentration was observed, providing insight into the critical involvement of H+ in the mechanism of electron transfer. Complex 1 was also shown to be competent to oxidize a series of dihydronicotinamide adenine dinucleotide (NADH) analogues via formal hydride transfer to produce the corresponding NAD+ analogues and [2-OH]?. The logarithms of the observed second-order rate constants of hydride transfer (k(H)) from NADH analogues to 1 are linearly correlated with those of hydride transfer from the same series of NADH analogues to p-chloranil. 相似文献