C4馏分中微量乙腈的大口径毛细管色谱测定

采用水相萃取富集技术，利用大口径厚液膜HLZ－60石英毛细管色变柱对C4烃抽余液中的微量乙腈进行分析；结果表明LZP－60石英毛细管色谱柱对乙腈化合物具有良好的惰性和色谱选择性；残余烃杂质峰和大量水分不干扰乙腈峰的流出；定量分析结果表明，样品测量的相对标准偏差为15％，其相对误差为7％，色谱分离检测法完全满足实际工作中微量乙腈分析的需要。     

壳聚糖/Pb(Ⅱ)模板壳聚糖膜与Pb(Ⅱ)螯合反应的动力学及机理探讨

Chitosan and chitosan membranes with Pb(Ⅱ) ion as template were studied. The adsorption isotherms were correlated by dc/dt=-kcⁿ at the temperature of 30 ℃, 35 ℃, 40 ℃, 45 ℃, 50 ℃. By means of linear correlation, the shapes of the isotherm curves were similar to the kinetic function of 2/c^1/2=-kt and the apparent activation energy for with chitosan(123.8 kJ·moL^-1) was larger than that of membrane with Pb(Ⅱ) ion(92.3kJ·moL^-1). The chitosan membrane with Pb(Ⅱ) ion template was better “memory” function. The adsorption mechanism of chitosan with Pb(Ⅱ) was studied by IR and XPS. The results indicated that the nitrogen in -NH₂ and the oxygen in C₃-OH of chitosan were coordination atoms.     

基于吡咯烷与正丁烷类衍生物CCR5拮抗剂的药效团模型构建

吡咯烷与正丁烷类CCR5(化学趋化因子受体5)拮抗剂可通过抑制人类免疫缺陷病毒(HIV-1)包膜蛋白与CCR5的相互作用而阻断病毒进入细胞. 本文使用已知拮抗剂结构和活性信息构建了一个三维药效团模型. 按照Catalyst/HypoGen模块的要求, 选择了25个结构和活性均具备差异性的分子作为药效团产生的训练集. 其中训练集分子以IC50值表示的生物活性值跨度为0.06到10000 nmol·L-1. 最好的药效团模型(Hypo 1)由两个正离子化特征以及三个疏水特征组成, 训练集预测相关系数为0.924, 均方根偏差为1.068. 模型用于预测由74个分子组成的测试集化合物活性, 结果表明模型可以提供较好的活性预测结果并用于新的拮抗剂的设计.     

等离子体聚合法制备膜蒸馏用疏水微孔复合膜

本文以八氟环丁烷为单体,采用等离子体聚合法将亲水性硝酸纤维素微孔膜改性,制得疏水硝酸纤维素微孔复合膜。所得疏水微孔复合膜可用于膜蒸馏,并具有优良的膜蒸馏性能,其通量达到反渗透水平。利用扫描电镜、X-射线显微分析和XPS等分析手段研究了聚合条件对所得复合膜结构性能的影响.     

接触角法研究氨丙基硅烷化石英表面

利用接触角法研究了氨丙基硅烷化石英表面的基团浓度及单分子层中单个分子的截面积。提出了氨丙基硅烷化的模型。     

Construction of Recombinant Modified Vaccinia Ankara （MVA） Expressing Hepatitis B Virus Surface Antigen

Introduction Despitetheexistenceofeffectiveprophylacticvac cinesagainstthehepatitisBvirus(HBV)formany years,HBVinfectionremainsaserioushealthproblem worldwide.Approximatetwobillionpeoplehavebeen infectedbyHBVanditisestimatedthatmorethan350millionofthemare…     

Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum

A novel polypeptide was isolated from mistletoe Viscum coloratum. The primarystructure of the polypeptide ‘named viscotoxin B2‘ was determined to be KSCCKNTTGRNIYNT CRFAGGSRERCAKLSGCKIISASTCPSDYPK by Edman degradation. Viscotoxin B2 shared highsequence homology with viscotoxins isolated from Viscum album. Pharmacological experimentsshowed that viscotoxin B2 had distinct cytotoxic activity on tumor cells. Viscotoxin B2 could beused as a leading compound in cancer therapy.     

Synthesis and Crystal Structure of Neodymium Complex[Nd (C_(18)H_(20)N_2O_4) (NO_3)_3]

1INTRODUCT1oNMeta1liccomplexesofsomeSchiffbaseshaveantiviraIandfungistaticac-tivies[1-3i.SomeSchiffbasemetalliccomplexeshavecatalyticactivityasenzyme"'.Thisaspectacu1arresearchfield-WehavereportedthesynthesisandcrystalstructureofNd(llI)nitratecomplexwithN,N-disalicyclideneethylenediamineandDMSO(si'HerethetitlecomplexwasobtainedandcharacterizedbyX-raydiffrac-tion'Theligandisdischiffbaseofcondensationfrom2-hydroxyl-3-methoxyben-zoaldehydeandethylenediamine.2EXPERIMENTAL2.1Synthesi…     

手性2-(口恶)唑烷酮的无溶剂合成法

在无溶剂条件下,手性的β-氨基醇和脲在160-180℃反应0．5-1 h,在200℃反应0．5 h,高产率地获得手性噁唑烷酮。     

（四甲基二硅撑）双（3－三甲硅基环戊二烯基）－四羰基二铁的反应性

标题化合物（Ｍｅ_２ＳｉＳｉＭｅ_２）［η￣５－（３－Ｍｅ_３ＳｉＣ_５Ｈ_３）Ｆｅ（ＣＯ）_２］_２／（μ－ＣＯ）_２（Ａ）分子中的Ｆｅ－Ｆｅ键被钠汞齐还原断裂，生成相应的双铁负离子，分别与ＭｅＣＯＣｌ、ＰｈＣＯＣｌ、ＰｈＣＨ_２Ｃｌ、ＣｌＣＨ_２ＣＯＯＣ_２Ｈ_５和Ｐｈ_３ＳｎＣｌ进行亲核取代反应，生成在铁原子上引入相应取代基的产物（Ｍｅ_２ＳｉＳｉＭｅ_２）［η￣５－（３－Ｍｅ_３ＳｉＣ_５Ｈ_３）Ｆｅ（ＣＯ）_２Ｒ］_２（Ｒ：ＭｅＣＯ（１），ＰｈＣＯ（２），ＰｈＣＨ_２（３），ＣＨ_２ＣＯＯＣ_２Ｈ_５（４），Ｐｈ_３Ｓｎ（５），Ｉ（６））。Ａ在氯仿中与碘反应，得到Ｆｅ－Ｆｅ断裂的双铁碘化物，但在苯中与过量碘反应，则得到Ｆｅ－Ｉ－Ｆｅ桥联的离子型化合物（Ｍｅ_２ＳｉＳｉＭｅ_２）［η￣５－（３－Ｍｅ_３ＳｉＣ_５Ｈ_３）Ｆｅ（ＣＯ）_２］_２Ｉ·Ｉ（７）。化合物６的晶体和分子结构经Ｘ射线衍射测定，６属单斜晶系，Ｐ２１／ｃ空间群，ａ＝１．７２１７（４）ｎｍ，ｂ＝０．７７５３（２）ｎｍ，Ｃ＝１．３６２９（７）ｎｍ，β＝１０３．８０（３）°，Ｖ＝１．７６７（２）ｎｍ３，Ｚ＝４，Ｄｃ＝１．６２９９·ｃｍ－１，最终偏差因子Ｒ＝０．０５４。