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321.
Cu-ATSM: a radiopharmaceutical for the PET imaging of hypoxia 总被引:3,自引:0,他引:3
Copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone), Cu-ATSM, labeled with a positron emitting isotope of copper ((60)Cu, (61)Cu, (62)Cu or (64)Cu) has been shown, in vitro and in vivo, to be selective for hypoxic tissue. In silico studies have explored the mechanism of its hypoxia selectivity, and clinical studies with this agent have shown non-invasive imaging data that is predictive of a cancer patients' response to conventional therapy. This Perspective discusses the evolution of Cu-ATSM, how its selectivity can be improved upon, and where this metal-ligand platform could be taken in the future. 相似文献
322.
323.
Dixon IM Lebon E Loustau G Sutra P Vendier L Igau A Juris A 《Dalton transactions (Cambridge, England : 2003)》2008,(41):5627-5635
The synthesis of new ruthenium(II) terpyridine bipyridine complexes bearing a phosphorus(III) ligand is presented. The steric and electronic properties of the phosphorus ligand were varied using aminophosphines, alkyl and aryl phosphites and the bulky tri(isopropyl)phosphine. All complexes were characterized by multi-nuclear NMR spectroscopy, mass spectrometry and X-ray diffraction analysis. The electronic properties of the complexes were probed by cyclic voltammetry, absorption and luminescence spectroscopy. The complexes do not show luminescence at room temperature, whereas at 77 K in an alcoholic matrix, emission is observed in the range 600-650 nm with lifetimes of 3.5-5.5 micros, originating from 3MLCT states. The MLCT transition spans over 65 nm, which corresponds to a variation of 0.4 eV in the HOMO-LUMO gap. The oxidation potential of the ruthenium varies over a broad range of 290 mV, from +1.32 V vs. SCE with L = PiPr3 to +1.61 V vs. SCE with L = P(OPh)3. This range is unprecedented upon the variation of a single monodentate ligand coordinated by the same heteroatom in the same oxidation and charge states. This work underlines the specific capacity of phosphorus in bringing up a large variety of electronic properties by changing its substituents. 相似文献
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325.
Måns Andréasson Dr. Naresh Bhuma Dr. Nils Pemberton Dr. Erik Chorell 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(65):e202202020
This study aims to deepen the knowledge of the current state of rational G4-ligand design through the design and synthesis of a novel set of compounds based on indoles, quinolines, and benzofurans and their comparisons with well-known G4-ligands. This resulted in novel synthetic methods and G4-ligands that bind and stabilize G4 DNA with high selectivity. Furthermore, the study corroborates previous studies on the design of G4-ligands and adds deeper explanations to why a) macrocycles offer advantages in terms of G4-binding and -selectivity, b) molecular pre-organization is of key importance in the development of strong novel binders, c) an electron-deficient aromatic core is essential to engage in strong arene-arene interactions with the G4-surface, and d) aliphatic amines can strengthen interactions indirectly through changing the arene electrostatic nature of the compound. Finally, fundamental physicochemical properties of selected G4-binders are evaluated, underscoring the complexity of aligning the properties required for efficient G4 binding and stabilization with feasible pharmacokinetic properties. 相似文献
326.
Juris Meija 《Analytical and bioanalytical chemistry》2013,405(22):6897-6898
327.
Juris Meija 《Analytical and bioanalytical chemistry》2010,396(1):185-186
328.
329.
Semra Tan Sylwia Walus Jöns Hilborn Torbjörn Gustafsson Daniel Brandell 《Electrochemistry communications》2010,12(11):1498-1500
This paper presents a novel thin-film electrolyte of a 2:1 blend of polyetheramine (glyceryl poly(oxypropylene)) and cross-linked oligomeric poly(propylene oxide) diacrylate with LiTFSI. The polyetheramine acts as a surfactant, and can thereby be applied as a conformal coating on complex surfaces—here demonstrated for porous LiFePO4 cathodes—making it useful for 3D-microbatteries. The poly(propylene oxide) diacrylate blends with the surfactant and is easily UV cross-linked, thereby ensuring good mechanical stability. Electrolytes, ~ 2 μm thick, were casted onto LiFePO4 cathodes and cycled against metallic lithium, displaying stable discharge capacities of ~ 8 mAh/g at room temperature and ~ 120 mAh/g at 60 °C. The electrolyte showed conductivities of 3.45 × 10? 6 and 5.80 × 10? 5 S cm? 1 at room temperature and 60 °C, respectively. 相似文献
330.
Juris Meija 《Accreditation and quality assurance》2007,12(12):665-665