全文获取类型
收费全文 | 2131篇 |
免费 | 125篇 |
国内免费 | 7篇 |
专业分类
化学 | 1811篇 |
晶体学 | 13篇 |
力学 | 28篇 |
数学 | 228篇 |
物理学 | 183篇 |
出版年
2023年 | 31篇 |
2022年 | 50篇 |
2021年 | 84篇 |
2020年 | 93篇 |
2019年 | 67篇 |
2018年 | 35篇 |
2017年 | 42篇 |
2016年 | 84篇 |
2015年 | 92篇 |
2014年 | 86篇 |
2013年 | 124篇 |
2012年 | 161篇 |
2011年 | 199篇 |
2010年 | 113篇 |
2009年 | 90篇 |
2008年 | 141篇 |
2007年 | 118篇 |
2006年 | 105篇 |
2005年 | 86篇 |
2004年 | 80篇 |
2003年 | 56篇 |
2002年 | 40篇 |
2001年 | 17篇 |
2000年 | 11篇 |
1999年 | 12篇 |
1998年 | 10篇 |
1997年 | 8篇 |
1996年 | 16篇 |
1995年 | 6篇 |
1994年 | 11篇 |
1993年 | 14篇 |
1992年 | 7篇 |
1991年 | 10篇 |
1990年 | 7篇 |
1988年 | 10篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 14篇 |
1984年 | 11篇 |
1982年 | 18篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 11篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 14篇 |
1975年 | 5篇 |
1974年 | 5篇 |
1973年 | 9篇 |
1930年 | 3篇 |
排序方式: 共有2263条查询结果,搜索用时 15 毫秒
131.
Apoptolidin is a natural product that selectively induces apoptosis in several cancer cell lines. Apoptosis, programmed cell death, is a biological key pathway for regulating homeostasis and morphogenesis. Apoptotic misregulations are connected with several diseases, in particular cancer. The extrinsic way to apoptosis leads through death ligands and death receptors to the activiation of the caspase cascade, which results in proteolytic degradation of the cell architecture. The intrinsic pathway transmits signals of internal cellular damage to the mitochondrion, which loses its structural integrity, and forms an apoptosome that initiates the caspase cascade. Compounds which regulate apoptosis are of high medical significance. Many natural products regulate apoptotic pathways, and apoptolidin is one of them. The known synthetic routes to apoptolidin are described and compared in this Review. Selected further natural products which regulate apoptosis are introduced briefly. 相似文献
132.
Solution equilibrium studies on the Cu(II)–polyamine–histidine ternary systems (polyamine: ethylenediamine (en), diethylenetriamine (dien), N,N,N′,N″,N″-pentamethyldiethylenetriamine (Me5dien)) have been performed by pH-potentiometry, UV–Vis spectrophotometry and EPR methods. The obtained results suggest the formation of the mixed-ligand complexes with [Cu(A)(His)]+ stoichiometry in all studied systems. Additionally, in the systems with dien and Me5dien protonated [Cu(A)(H–His)]2+ species also exists in acid solution. Our spectroscopic results indicate the tetragonal geometry for the [Cu(en)(His)]+, the geometry slightly deviated from square pyramidal for the [Cu(dien)(His)]+ and strongly deviated from square pyramidal towards trigonal bipyramidal for the [Cu(Me5dien)(His)]+ species. The coordination modes in these mixed-ligand complexes are discussed. 相似文献
133.
134.
Julia J. Chang Andrew Martin Chuanshen Du Alana M. Pauls Martin Thuo 《Angewandte Chemie (International ed. in English)》2020,59(38):16346-16351
Fabrication of bio‐templated metallic structures is limited by differences in properties, processing conditions, packing, and material state(s). Herein, by using undercooled metal particles, differences in modulus and processing temperatures can be overcome. Adoption of autonomous processes such as self‐filtration, capillary pressure, and evaporative concentration leads to enhanced packing, stabilization (jamming) and point sintering with phase change to create solid metal replicas of complex bio‐based features. Differentiation of subtle differences between cultivars of the rose flower with reproduction over large areas shows that this biomimetic metal patterning (BIOMAP) is a versatile method to replicate biological features either as positive or negative reliefs irrespective of the substrate. Using rose petal patterns, we illustrate the versatility of bio‐templated mapping with undercooled metal particles at ambient conditions, and with unprecedented efficiency for metal structures. 相似文献
135.
In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)
下载免费PDF全文
![点击此处可从《Angewandte Chemie (International ed. in English)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Julia Balog Dr. Sacheen Kumar James Alexander Ottmar Golf Dr. Juzheng Huang Tom Wiggins Nima Abbassi‐Ghadi Dr. Attila Enyedi Dr. Sandor Kacska James Kinross Prof. George B. Hanna Prof. Jeremy K. Nicholson Prof. Zoltan Takats 《Angewandte Chemie (International ed. in English)》2015,54(38):11059-11062
Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer‐related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo. 相似文献
136.
137.
138.
Magnus Pauly Julia Krger Viola Duppel Corban Murphey James Cahoon Bettina V. Lotsch Paul A. Maggard 《Chemical science》2022,13(11):3187
The in-depth understanding of the reported photoelectrochemical properties of the layered carbon nitride, poly(triazine imide)/LiCl (PTI/LiCl), has been limited by the apparent disorder of the Li/H atoms within its framework. To understand and resolve the current structural ambiguities, an optimized one-step flux synthesis (470 °C, 36 h, LiCl/KCl flux) was used to prepare PTI/LiCl and deuterated-PTI/LiCl in high purity. Its structure was characterized by a combination of neutron/X-ray diffraction and transmission electron microscopy. The range of possible Li/H atomic configurations was enumerated for the first time and, combined with total energy calculations, reveals a more complex energetic landscape than previously considered. Experimental data were fitted against all possible structural models, exhibiting the most consistency with a new orthorhombic model (Sp. Grp. Ama2) that also has the lowest total energy. In addition, a new Cu(i)-containing PTI (PTI/CuCl) was prepared with the more strongly scattering Cu(i) cations in place of Li, and most closely matching with the partially-disorder structure in Cmc21. Thus, a complex configurational landscape of PTI is revealed to consist of a number of ordered crystalline structures that are new potential synthetic targets, such as with the use of metal-exchange reactions.The layered carbon nitride, poly(triazine imide), exhibits a complex configurational landscape for the coordination of cations within its intralayer cavities that has been elucidated for the first time. 相似文献
139.
We prove that group (co)homology can be computed up to bounded torsion using certain generalized projective resolutions. We investigate the notion of dimension obtained using this kind of resolutions and its relationship with the existence of torsion in both ordinary and complete cohomology groups. 相似文献
140.
Xiaodong Hou Jonathan Butz Jiao Chen Zijun D. Wang Julia X. Zhao Tiffany Shiu Qianli Rick Chu 《Tetrahedron letters》2017,58(1):101-105
A group of new low molecular weight organogelators based on threefold symmetric tricarbamate were synthesized and characterized. The tricarbamates with long alkyl chains were able to gelate a wide range of polar and nonpolar organic solvents such as acetonitrile and cyclohexane, generally at concentrations lower than 20 g/L. The best organogel formation was obtained using a threefold symmetric tricarbamate in n-dodecane, in which a sufficiently transparent gel was formed at the critical gelation concentration 1 g/L. Intermolecular hydrogen bonding by the tricarbamate in a nonpolar solvent benzene-d6 was indicated by 1H NMR spectra. Its maximum UV absorption was 11 nm higher in chloroform than in n-dodecane, and this red shift indicated increased conjugation between the benzene core and the carbamate substituents, which confirmed a change in its conformation from nonpolar to polar solvent. The self-assembling behavior of the tricarbamate in dilute solutions was investigated by TEM. Fiber-like networks were observed in a large range of solution concentrations. 相似文献