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991.
[reaction: see text]. Alpha-carbolines are interesting core structures for designing DNA-interacting small molecules. However, these compounds are not commercially available and their synthetic methods are low yielding or time consuming. The shortest synthetic route, the modified Graebe-Ullmann reaction, has been optimized by using microwave heating in four different types of apparatus to give shorter reaction times and enhanced yields. Optimized conditions enabled the preparation of a small library of alpha-carbolines. 相似文献
992.
用聚丙烯酸叔丁酯-b-聚乙二醇(PtBA45-b-PEG114)和聚丙烯酸叔丁酯-b-聚4-乙烯基吡啶(PtBA60-b-P4VP80)制备了复合胶束. 该胶束在pH=2.5的酸性水溶液中形成以PtBA为核, PEG和P4VP为壳的稳定球型结构. 在pH=12时, 壳层的P4VP链段变为疏水, 塌缩在PtBA的核上形成内壳, PEG链段继续保持溶解状态, 与成核的PtBA连接并穿过塌陷的P4VP内壳, 形成胶束的冠, 由于PEG处于溶解状态, 其分子链间有比较大的空隙, 可以控制一些小分子通过, 在胶束的表面形成通道. 该通道类似于生物膜的蛋白通道, 可以控制PtBA核与外界进行能量或物质交换的速度. 以布洛芬为模型分子, 负载在胶束内进行药物控制释放研究的结果表明, 胶束表面的通道可以起到明显控制布洛芬释放速度的作用, 并且药物的释放速度与通道在胶束表面的比例成正比. 相似文献
993.
Eleonora Freire Sergio Baggio Juan Carlos Muoz Ricardo Baggio 《Acta Crystallographica. Section C, Structural Chemistry》2003,59(8):m299-m301
The structure of the title compound, [Ni(ths)(bbip)(dmf)]·H2O [ths is thiosulfate, S2O3; bbip is 2,6‐bis(1H‐benzimidazol‐2‐yl)pyridine, C21H13N5; and dmf is dimethylformamide, C3H7NO], is monomeric, with the nickel ion octahedrally surrounded by an N,N′,N′′‐tridentate bbip molecule, an S,O‐bidentate ths molecule and an O‐monodentate dmf molecule. The H atoms of the hydration water molecule and the amino groups of bbip are involved in hydrogen bonding and determine a spatial organization of broad layers parallel to (001), which are connected by weak interactions. 相似文献
994.
995.
A facile microarray-based fluorescent sensor for the detection of lead (II) was developed based on the catalytic cleavages of the substrates by a DNAzyme upon its binding to Pb(2+). The release of the fluorophore labelled substrates resulted in the decrease of fluorescence intensity. The sensor had a quantifiable detection range from 1 nM to 1 μM and a selectivity of >20 fold for Pb(2+) over other metal ions. 相似文献
996.
Jaime L. Matta Juan M. Ramos Roy A. Armstrong Hector D'Antoni 《Photochemistry and photobiology》2005,81(3):563-568
Apoptosis involves a highly organized and programmed series of events aimed at maintaining genomic stability by eliminating defective host cells. The purpose of this study was to determine the threshold doses and environmental UV‐A and UV‐B exposure times necessary to produce apoptosis and necrosis in the normal cells of a human fibroblast cell line. Enviromental UV‐A and UV‐B doses were measured over a 6 year period with a four‐channel UV radiometer. The fibroblasts were irradiated once using an Oriel UV Solar Simulator with six doses of environmentally‐based UV. Doses corresponded to 0,11,19,23 and 45 min of average environmental UV‐A and UV‐B radiation at solar noon in Puerto Rico. The Annexin‐V binding method was used to differentiate between normal fibroblasts and apoptotic or necrotic fibroblasts. The threshold dose from apoptosis to necrosis was found between 24–28 kJ/m2, which corresponded to 19 and 23 min of environmental UV‐A and UV‐B exposure. This study provides the first data that specify the environmental threshold doses of UV‐A and UV‐B at which human fibroblasts undergo apoptosis and necrosis. These results may provide valuable dose‐response thresholds for apoptosis and necrosis for future mechanistic studies and baseline data for skin cancer prevention programs. 相似文献
997.
MAWei-Xing HUZhao-Hui ZHOULi-Juan ZHUJi-Zhen LUJuan 《理论物理通讯》2003,40(6):699-701
Based on Glauber Multiple Scattering Theory, high-energy proton elastic scattering on halo-like nucleus ^13C is studied in a single nucleon wave function with low angular momentum configurations. A great agreement with experimental data is obtained and the theoretical prediction clearly shows that 13U has a neutron halo-like structure.Then, the origin and nature of nuclear halo phenomena are explained in terms of nuclear short-range correlations. Our conclnsion shows ttiat the origin of nuclear halo-like phenomena originates from short range nuclear correlation. 相似文献
998.
Toribio L del Nozal MJ Bernal JL Alonso C Jiménez JJ 《Journal of chromatography. A》2007,1144(2):255-261
The chiral resolution of four antifungal compounds, three imidazoles (miconazole, econazole and sulconazole) and one triazole (itraconazole) using supercritical fluid chromatography on the amylose-based chiral stationary phase Chiralpak AD, is presented in this work. The influence of pressure, type and percentage of organic modifier and temperature on retention times and resolution was studied. The enantiomeric separation of the three imidazoles was achieved with resolutions higher than two and analysis times lower than 10 min, obtaining the best results using methanol as modifier. However, the analysis time of the triazole was higher than 80 min due to the existence of a high number of functional groups that were able to interact with the chiral stationary phase. In this case, the resolution of the four stereoisomers was achieved only partially with mixtures of ethanol and 2-propanol as modifier. The isoenantioselective temperatures were obtained from the study of the influence of the temperature, they were above the range of temperatures assayed, except for sulconazole using 2-propanol. 相似文献
999.
本文合成了双核铜(II)和钴(II)配合物,并用动力学方法研究了它们对双-(对硝基苯基)磷酸二酯(BNPP)水解的催化活性。实验结果表明,单去质子化的肟基可以作为反应过程中的分子内亲核剂。双核铜(II)配合物比与其具有相似结构的单核配合物催化底物水解的活性高很多的事实表明,在双核配合物作催化剂的体系中很可能包含两个金属中心的双路易斯酸催化的机理。 相似文献
1000.
以四水合氯化亚铁和硝酸银为原料,硼氢化钠为还原剂,氧化石墨烯(GO)为载体,通过原位还原法制备了具有磁分离功能的银/四氧化三铁/还原氧化石墨烯(Ag/Fe_3O_4/rGO)纳米复合抗菌材料.采用X射线粉末衍射仪(XRD)、X射线光电子能谱仪(XPS)、透射电子显微镜(TEM)等对复合材料进行了表征.结果显示,Fe_3O_4和Ag纳米颗粒均匀分布在rGO片层上.复合材料的饱和磁化率(Ms)为40.5 A·m~2·kg·(-1),表明其具有较强的磁性,将其与菌液混合后,在磁场作用下10 min即可吸附沉降完成磁分离.以大肠杆菌(E.coli)和金黄色葡萄球菌(S.aureus)为实验菌株,通过琼脂扩散法评价了复合材料的抗菌性能.结果表明,该复合材料具有良好的抗菌效果,对E.coli和S.aureus的抑菌圈直径分别为18 mm和13 mm,最低抑菌浓度值(MIC)分别为50 mg/L和80 mg/L,最低杀菌浓度值(MBC)分别为30 mg/L和50 mg/L. 相似文献