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81.
82.
S. Banerjee S. N. Ganguli A. Gurtu R. Raghavan A. Subramanian Y. Goldschmidt-Clermont R. T. Ross S. Squarcia K. Dziunikowska T. Haupt P. Girtler D. Kuhn K. W. J. Barnham J. Wells P. R. S. Wright J. Macnaughton F. Mandl F. Shabaan M. Bardadin-Otwinowska M. Szczekowski 《Zeitschrift fur Physik C Particles and Fields》1986,31(3):401-408
Results on inclusive ? production inK ? p interactions at 110 GeV/c are presented. The production cross section is found to be larger than in πp andpp interactions at similar energies, suggesting OZI allowed \(s\bar s\) fusion to be the dominant mechanism in ? production. Thex distributions of ? and \(\bar K^{*0} \) are found to be similar to each other over the entirex range suggesting an overall strangeness suppression factor of 0.20±0.04 in the sea to be the dominant source of the difference in the cross section for ? and \(\bar K^{*0} \) . There is no evidence of a narrowφπ ? state around 2.1 GeV/c2 as suggested byK + experiments, but there is some excess of events in the region 1.94?1.98 GeV/c2 consistent with theF-meson mass as observed ine + e ? experiments. 相似文献
83.
Cytochrome-c detection 总被引:2,自引:0,他引:2
Following a myocardial infarction (MI) cells die or are damaged and their contents leak into the blood circulation, resulting
in elevated serum levels of various enzymes, proteins, and organic molecules. Over the past few decades, it has become standard
practice to employ the detection of these elevated substances as markers for the confirmation of MIs and to monitor MI patients’
response to treatment. Although it has previously been shown that cytochrome-c, a small respiratory protein, is among those elevated, the lack of a suitable detection system has prevented its routine
use in the diagnosis of MIs. We present a preliminary study in which chemiluminescence was employed to detect elevated levels
of cytochrome-c in the serum of MI patients. The technique, which is specific for c-type proteins, is approx 30 times more sensitive than the traditional Coomassie blue stain and can detect as little as 0.03
μg of protein. It also has potential for diagnostic use in other diseases that are characterized by mitochondrial damage. 相似文献
84.
Joseph I. Degraw Lawrence F. Kelly Roy L. Kisliuk Yvette Gaumont Francis M. Sirotnak 《Journal of heterocyclic chemistry》1982,19(6):1587-1588
A synthesis of 8,10-dideazaminopterin, using 2,4-diamino-6-bromomethyl-8-deazapteridine ( 2 ) as a key intermediate, is described. Condensation of the triphenylphosphinylide derived from 2 with p-formylbenzoyl-L-glutamate afforded a 9,10-dehydro-8,10-dideazaminopterin ester intermediate 5 . Hydrogenation of the olefinic linkage and subsequent hydrolysis of the glutamate ester gave the title compound. 8,10-Dideazaminopterin was a potent growth inhibitor of folate dependent bacteria. It was 16 times more potent then methotrexate as an inhibitor of dihydrofolate reductase derived from L1210 leukemia cells, and showed strong activity against L1210 in mice. 相似文献
85.
Maria A. Curtin Irwin A. Taub Kenneth Kustin Narith Sao Jeremy R. Duvall Katharine I. Davies Christopher J. Doona Edward W. Ross 《Research on Chemical Intermediates》2004,30(6):647-661
The slow reaction between peroxodisulfate and formate is significantly accelerated by ascorbate at room temperature. The products of this induced oxidation, CO2 and oxalate (C2O2–
4), were analyzed by several methods and the kinetics of this reaction were measured. The overall mechanism involves free radical species. Ascorbate reacts with peroxodisulfate to initiate production of the sulfate radical ion (SO–
4), which reacts with formate to produce carbon dioxide radical ion (CO–
2) and sulfate. The carbon dioxide radical reacts with peroxodisulfate to form CO2 or self-combines to form oxalate. Competition occurring between these two processes determines the overall fate of the carbon dioxide radical species. As pH decreases, protonation of the carbon dioxide radical ion tends to favor production of CO2. 相似文献
86.
Crouch R Boyer RD Johnson R Krishnamurthy K 《Magnetic resonance in chemistry : MRC》2004,42(3):301-307
Compensation of refocusing inefficiency in a gHMBC experiment by replacing the rectangular pi pulse with a pair of adiabatic pulses with synchronized inversion sweep (CRISIS) significantly improves the performance of the gHMBC experiment. The CRISIS-gHMBC experiment retains the pure absorptive shapes in F1 and hence results in better lineshape and higher resolution than the current versions of magnitude mode gHMBC spectra. When used as a broadband experiment, CRISIS-gHMBC, owing to better refocusing efficiency of the adiabatic pulse pairs, gives improved performance across the 13C spectral width. Moreover, it is shown that CRISIS-gHMBC is a robust and improved alternative and when used along with the IMPRESS (Improved Resolution using Symmetrically Shifted pulses) technique further increases the sensitivity and resolution without additional experimental time. The IMPRESS-CRISIS combination is demonstrated for broadband gHMBC and band-selective gHMBC experiments. The ICbs-gHMBC [IMPRESS-CRISIS-band-selective gHMBC] experiment is an attractive and better alternative to individual band-selective gHMBC. 相似文献
87.
Joseph A. Akkara Kris J. Senecal David L. Kaplan 《Journal of polymer science. Part A, Polymer chemistry》1991,29(11):1561-1574
Polymers were synthesized from substituted phenolic and aromatic amine compounds with hydrogen peroxide as the source of an oxidizing agent and horseradish peroxidase enzyme as the catalyst. The polymerization reaction was carried out in a monophasic organic solvent with small amounts of water at room temperature. Conditions for the synthesis of polymers with respect to reaction time and yield were studied with a number of monomers at different concentrations and in solvents with different buffers with pH range of 5.0–7.5. Physical and chemical properties of these homo-and copolymers were determined with respect to melting point, solubility, elemental analysis, molecular weight distribution, infrared absorption (including FTIR), solid-state 13C nuclear magnetic resonance, thermal gravimetric analysis, and differential scanning calorimetry. The enzyme catalyzed reactions produced polymers of molecular weight greater than 400,000 which were further fractionated by differential solubility in solvent mixtures and the molecular weight distribution of the polymer fractions were determined. In general, the polymers synthesized have low solubilities, high melting points, and some degree of branching. 相似文献
88.
Donathan G. Beasley John Beard Joseph W. Stanfield Lee K. Roberts 《Photochemistry and photobiology》1996,64(2):303-309
Expense and inconvenience have restricted the use of the filtered xenon are lamp (solar simulator) as a UV source for conducting large-scale animal studies. Because sunscreen immunoprotective levels are significantly affected by the UV power spectrum of the source it is imperative that a solar simulating source be used for accurate measurements of sunscreen protection levels that are relevant to human UV exposures from sunlight. However, relatively inexpensive sunlamps, e. g. the UVA-340, that emit a UV power spectrum similar to that of a solar simulator are available. Unlike FS-type UVB sunlamps, which have a significant amount of effective immunosuppressive nonsolar UV energy at wavelengths below 295 nm, the immunosuppression effectiveness spectrum of UVA-340 sunlamps was nearly identical to that of a solar simulator. The purpose of this study was to evaluate this sunlamp for conducting photoimmunological and sunscreen immune protection studies. Groups of C3H mice were exposed to a range of UVA-340 sunlamp doses (0.25 KJ/m2 to 20.0 KJ/m2) to establish a dose-response curve and determine the minimum immune suppression dose (MISD) for induction of local-type suppression of contact hypersensitivity (CH). The MISD, defined as the lowest UV dose given to produce ~50% suppression of the CH response in mice, was determined to be 1.0 kJ/m2 for UVA-340 sunlamps. Immune protection tests on four marketed sunscreen lotions (sun protection factors [SPF] 4, 8, 15 and 30) were then conducted with UVA-340 sunlamps using MISD as the endpoint. The immune protection factors for these sunscreens were equivalent to the level of protection predicated by their labeled SPF. These results are similar to those we have previously obtained using a solar simulator. We conclude from these data that the immunosuppressive effects of UVA-340 sunlamps are similar to those of a solar simulator; however, further studies are needed to determine if UVA-340, or similar, sunlamps are a viable alternative to the solar simulator for conducting large-scale animal experiments that require a relevant UV solar spectrum. 相似文献
89.
The solid-phase synthesis of the octapeptide 1 AcGly-Ala-Lys-Arg-His-Arg-Lys-ValOMe, which represents the fragment 14-21 of the amino acid sequence of the chromosomal histone H4, as well as of the structurally related nonapeptide 2 AcGly-Ala-Lys-Leu-Arg-His-Arg-Lys-ValOMe, is described using a new polyacrylic resin containing a glycolamide ester linkage(resin-NHCO-CH2-OCO-peptide) acting as a labile anchoring moiety between the resin and the peptide.After elongation of the polypeptide chain using classical protecting groups, i.e. t-butyloxycarbonyl for the α-NH2 function, benzyloxycarbonyl, nitro and 2,4-dinitrophenyl groups for the side-chains of Lys, Arg and His respectively, both peptides 1 and 2 were obtained in good yields and with a high purity as shown by high-pressure liquid chromatography, by amino-acid analysis and by high-field proton NMR spectroscopy.This work demonstrates the ability of the newly introduced polyacrylic resin to act as a convenient support for solid-phase peptide synthesis. 相似文献
90.
An inductively coupled plasma-atomic emission spectrometric method is reported for the determination of calcium, copper, iron, manganese, magnesium and zinc. Samples are introduced directly when a sheath gas device is used. An external calibration procedure is used. The standards are prepared in a matrix composed of 0.5% (w/v) albumin and 0.76% (w/v) sodium chloride. The procedure was evaluated with a standard reference material (NBS SRM 909 Human Serum); all the values obtained are in agreement with the certified values. Results obtained for the determination of zinc, calcium, magnesium, copper, iron and manganese in amniotic fluid samples are reported. 相似文献