Developing safe and efficient delivery systems for therapeutic biomacromolecules is a long-standing challenge. Herein, we report a newly developed combinatorial library of cholesteryl-based disulfide bond-containing biodegradable cationic lipidoid nanoparticles. We have identified a subset of this library which is effective for protein and mRNA delivery in vitro and in vivo. These lipidoids showed comparable transfection efficacies but much lower cytotoxicities compared to the Lpf2k in vitro. In vivo studies in adult mice demonstrated the successful delivery of genome engineering protein and mRNA molecules in the skeletal muscle (via intramuscular injection), lung and spleen (via intravenous injection), and brain (via lateral ventricle infusion). 相似文献
A record power conversion efficiency of 8.40 % was obtained in single-component organic solar cells (SCOSCs) based on double-cable conjugated polymers. This is realized based on exciton separation playing the same role as charge transport in SCOSCs. Two double-cable conjugated polymers were designed with almost identical conjugated backbones and electron-withdrawing side units, but extra Cl atoms had different positions on the conjugated backbones. When Cl atoms were positioned at the main chains, the polymer formed the twist backbones, enabling better miscibility with the naphthalene diimide side units. This improves the interface contact between conjugated backbones and side units, resulting in efficient conversion of excitons into free charges. These findings reveal the importance of charge generation process in SCOSCs and suggest a strategy to improve this process: controlling miscibility between conjugated backbones and aromatic side units in double-cable conjugated polymers. 相似文献
A low temperature and cost-effective process for antimicrobial finishing of cotton textiles has been developed by sol–gel
method. The antimicrobial treatment was performed by treating cotton textile with silica sols from water glass and then with
silver nitrate solution. The antimicrobial activity was determined by using E. coli as a model for Gram-negative bacteria. The results showed that the treated textile has an excellent antimicrobial effect
and laundering durability. SEM analysis showed coarse surface morphological change on the water glass treated cotton textile.
The residual concentration of silver ion on fabrics was informed by ICP-MS. XPS results indicated that two different states
of silver were present on the surface of the antimicrobial textile. 相似文献
Plasma surface-treatment of silk and cotton fabrics were carried out in a hexafluoropropene (C3F6) atmosphere under different experimental conditions. Analysis of the treated fibers by X-ray photoelectron spectroscopy (XPS) indicated about 50 at% fluorine atoms were incorporated in the surface structure of two fibers and confirmed the presence of -CF, -CF2, -CF3 groups on the surface. After water-washing and alcohol-extraction, though partial loss of fluorine from the surface has been observed, contact angle and wet-out time measurements on the fibers still show much improved hydrophobic properties. The other properties of the treated fabrics, such as water vapor permeability and tensile strength were also evaluated. 相似文献
A novel glycosyl amino acid hydrophilic interaction chromatography (HILIC) stationary phase was prepared via click chemistry. The key intermediate N3-glycosyl d-phenylglycine was prepared by a three steps procedure, including selective condensation of amino glucose with N-succinimidyl ester of Boc-d-phenylglycine, deprotection and transformation of amino group to azido group. The structure of all the intermediates and functionalized silica beads were confirmed by 1H NMR, IR, elemental analysis and 13C CP-MAS. The chromatography test showed that this new type of separation material possessed good HILIC properties and glycopeptide enrichment characteristics. Nucleosides and bases could be separated in a simple eluent composition (only acetonitrile in combined with water), and with the same condition, these model compounds could not be separated on the commercial HILIC column (Atlantis). Click glycosyl amino acid thus prepared also showed longer retention and better separation ability in the separation of polar organic acids. 相似文献
Durable superhydrophobic surface on cotton fabrics has been successfully prepared by sol–gel method. Cellulose fabric was
first coated with silica sol prepared with water glass and citric acid as the acidic catalyst. The silica coated fabric was
then padded with hydrolyzed hexadecyltrimethoxysilane afterwards obtaining low surface energy. Water contact angle and hydrostatic
pressure were used to characterize superhydrophobicity and washing durability. Scanning electron microscopy was used to characterize
the surface morphology changes after certain washing times. All results showed good durable hydrophobicity on cellulose fabrics.
In addition, the influence of citric acid and sodium hypophosphite (NaH2PO2) on the durability of hydrophobicity was also investigated. The durability of treated cotton improved with the increase of
concentration of citric acid in the presence of NaH2PO2. It could be concluded that citric acid acted as multi-functional heterogeneous grafting chemicals to improve washing durability
of hydrophobicity by forming the ester bonds between cotton fabric and silica sol and improved the durability of hydrophobicity. 相似文献
By kinetic control over the zeolite seed formation, we report the direct fabrication of hierarchical mesoporous zeolites using hexadecyl trimethyl ammonium bromide (CTAB) as the soft template in a conventional solution route. Nanometer-sized, subnanocrystal-type zeolite seeds with a high degree of polymerization are essential to prevent the formation of a separate amorphous mesoporous phase and the phase separation between the mesophase and zeolite crystals in the presence of CTAB and a certain amount of ethanol. The mechanisms for the formation of hierarchically porous zeolites in the solution process, including the effect of mother liquid aging, formation of subnanocrystal zeolite seeds and their self-assembly effect with CTAB, and the role of ethanol are proposed and discussed in detail. The prepared mesoporous ZSM-5 zeolite showed much higher catalytic activity than conventional counterparts for aldol condensations involving large molecules, especially in the synthesis of vesidryl. 相似文献
Stimulus-responsive polymers with luminescence properties have a wide range of applications in the fields of controlled drug release, fluorescent probes, and biological stents. In this paper, carbon dioxide (CO2)/oxygen (O2) dual-responsive fluorescent diblock copolymers were synthesized by the reversible addition-fragmentation chain transfer (RAFT) polymerization method with two fluorescent monomers synthesized as its luminescence source, DEAEMA (CO2 responsive monomer) and tFMA (O2 responsive monomer). An experimental study demonstrated that the synthesized stimulus-responsive fluorescent polymer had a high sensitivity to CO2; the double-responsive fluorescent diblock copolymer could form and achieve the reversal of polymer micelles in the aqueous solution when it was sequentially subjected to the introduction of CO2 and O2.