新型PTP 1B抑制剂喹啉腙及酰腙化合物的合成与活性研究

喹啉腙及喹啉酰腙类化合物具有广泛的生物活性.本文设计合成了29个未见报道的4-(2-芳基)喹啉芳腙和芳酰腙类化合物,采用光吸收检测法测试所合成化合物对蛋白酪氨酸磷酸酶PTP 1B的抑制作用.结果 表明,喹啉腙类化合物对PTP 1B具有显著的酶抑制作用,在20μ g/mL浓度时,有21个化合物对PTP 1B抑制率在80％...     

3cm接收前端的小型化设计

介绍了3 cm低噪声接收前端的设计方法及为使其小型化应用使用了芯片GaAS MMIC混频器,并使用MWO软件对低噪声放大器电路进行了仿真。仿真数据和实测结果都表明,所设计的放大器具有较低的噪声和带内起伏,接收前端具有较高的镜像抑制度及良好的带外抑制。     

（FeCp2）0．65FNi（C3S7）2]的合成及表征

合成了一种新型的导电配位型化合物（FeCp2）0．65FNi（C3S7）2].通过元素分析（EA），电感耦合等离子体原子发射光谱（ICP—AES），核磁共振（^1HNMR），紫外光谱（UV）对该化合物进行了表征。     

Building 2D classification models and 3D CoMSIA models on small-molecule inhibitors of both wild-type and T790M/L858R double-mutant EGFR

Molecular Diversity - Epidermal growth factor receptor (EGFR) has received widespread attention because it is an important target for anticancer drug design. Mutations in the EGFR, especially the...     

A wide dynamic range laser rangefinder with cm-level resolution based on AGC amplifier structure

A pulsed time-of-flight (TOF) laser rangefinder with a pulsed laser diode and an avalanche photo diode (APD) receiver is constructed and tested. Trigged by an avalanche transistor, the laser diode can emit a periodic pulse with rise time of ～2 ns. A new structure with auto gain control (AGC) circuits both in the pre-amplifier and the post-amplifier is presented. Through this technology, not only the dynamic range of the receiver is extended, but also the walk error of timing discriminators is reduced. Large measurement range from 5 m to 500 m is achieved without any cooperative target. The single-shot precision is 3 cm for the weakest signal. Compared with previous laser rangefinders, the complexity of this system is greatly simplified.     

Dissociative and molecular oxygen chemisorption channels on reduced rutile TiO2(110): An STM and TPD study

High-resolution scanning tunneling microscopy (STM) and temperature-programmed desorption (TPD) were used to study the interaction of O₂ with reduced TiO₂(110)–(1 × 1) crystals. STM is the technique of choice to unravel the relation between vacancy and non-vacancy assisted O₂ dissociation channels as a function of temperature. It is revealed that the vacancy-assisted, first O₂ dissociation channel is preferred at low temperature (~ 120 K), whereas the non-vacancy assisted, second O₂ dissociation channel operates at temperatures higher than 150 K–180 K. Based on the STM results on the two dissociative O₂ interaction channels and the TPD data, a new comprehensive model of the O₂ chemisorption on reduced TiO₂(110) is proposed. The model explains the relations between the two dissociative and the molecular O₂ interaction channels. The experimental data are interpreted by considering the available charge in the near-surface region of reduced TiO₂(110) crystals, the kinetics of the two O₂ dissociation channels as well as the kinetics of the diffusion and reaction of Ti interstitials.     

狭缝的演变与彩虹全息术的发展

彩虹全息术的发生与发展是与狭缝的引入与演变相关的。本文试图用一个简明的表格形式把迄今为止存在着的各种彩虹全息图及其变化状态做一个形象化的小结。