全文获取类型
收费全文 | 144265篇 |
免费 | 10556篇 |
国内免费 | 6960篇 |
专业分类
化学 | 69364篇 |
晶体学 | 1408篇 |
力学 | 10994篇 |
综合类 | 515篇 |
数学 | 39616篇 |
物理学 | 39884篇 |
出版年
2024年 | 228篇 |
2023年 | 1399篇 |
2022年 | 2281篇 |
2021年 | 2353篇 |
2020年 | 2522篇 |
2019年 | 2423篇 |
2018年 | 12056篇 |
2017年 | 11671篇 |
2016年 | 8701篇 |
2015年 | 3868篇 |
2014年 | 3922篇 |
2013年 | 5132篇 |
2012年 | 9487篇 |
2011年 | 16059篇 |
2010年 | 9439篇 |
2009年 | 9754篇 |
2008年 | 10502篇 |
2007年 | 12239篇 |
2006年 | 3757篇 |
2005年 | 4337篇 |
2004年 | 3942篇 |
2003年 | 3791篇 |
2002年 | 2657篇 |
2001年 | 1752篇 |
2000年 | 1699篇 |
1999年 | 1709篇 |
1998年 | 1518篇 |
1997年 | 1309篇 |
1996年 | 1417篇 |
1995年 | 1183篇 |
1994年 | 1081篇 |
1993年 | 957篇 |
1992年 | 820篇 |
1991年 | 726篇 |
1990年 | 603篇 |
1989年 | 538篇 |
1988年 | 424篇 |
1987年 | 406篇 |
1986年 | 354篇 |
1985年 | 346篇 |
1984年 | 244篇 |
1983年 | 212篇 |
1982年 | 186篇 |
1981年 | 150篇 |
1980年 | 128篇 |
1979年 | 93篇 |
1978年 | 90篇 |
1977年 | 70篇 |
1975年 | 73篇 |
1973年 | 82篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Development of an LC‐MS/MS method for determining the pharmacokinetics of clonidine following oral administration of Zhenju antihypertensive compound
下载免费PDF全文
![点击此处可从《Biomedical chromatography : BMC》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jing Qin Limin Wang Lihong Wu Jun Chen Teng Shen Yongji Li Limei Han Jianxin Wang 《Biomedical chromatography : BMC》2015,29(7):1068-1075
Zhenju antihypertensive compound (ZJAHC) is a combined Chinese–Western medicine formula including clonidine (CLO), hydrochlorothiazide (HCT), rutin, Chrysanthemum indicum extract and pearl powder. Compared with CLO preparations, ZJAHC shows improved activities and decreased adverse effects. It is believed that the side effects of CLO are caused by its high peak plasma concentration. Hence, study of the influence of ZJAHC on the pharmacokinetic behaviors of clonidine seems essential. In present study, the plasma concentrations of CLO were determined with a liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method. The MS/MS transitions monitored for clonidine and internal standard were 230.2 → 213.1 and 152.2 → 110.2, respectively. The analyte was quantified in a single run within 3 min. The pharmacokinetic study showed that the area under the plasma concentration–time curve of CLO in ZJAHC (60 µg/kg CLO) was similar to that of CLO‐HCT‐high (120 µg/kg CLO) but the peak concentration was much lower than that in CLO‐HCT‐high. ZJAHC could enhance the bioavailability without greatly increasing peak concentration of clonidine. This comprehensive effect of enhancing the bioavailability and avoiding the high peak plasma concentration for CLO might mainly result from the co‐contribution of Western medicine and traditional Chinese medicine (TCM), while the effect of TCM was stronger than that of Western medicine. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
92.
Ping Chen Yanhong Hao Xinxin Wang Prof. Dr. Dan Yuan Prof. Dr. Yingming Yao Prof. Dr. Lutz Ackermann 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(30):7292-7297
Highly position selective alkylations of N-alkylindoles at C7-positions have been enabled by cationic zirconium complexes. The strategy provides a straightforward access to install alkyl groups at C7-positions of indoles without a complex directing group. Mechanistic studies provided support for the importance of Brønsted acids in the catalytic manifold. 相似文献
93.
Rongzhen Wu Hongyu Chen Dr. Ninghui Chang Yuzhi Xu Prof. Dr. Jiao Jiao Prof. Dr. Hailong Zhang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(6):1166-1195
Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014–present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1 , the most-studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development. 相似文献
94.
Nonlinear Dynamics - Nonlinear vibration isolation provides with an effective way for vibration reduction with broad band and high efficiency. This investigation focuses on the dynamic effects of a... 相似文献
95.
Guangrui Chen Yuxing Yan Dr. Jie Wang Prof. Yong Sik Ok Guiyuan Zhong Prof. Bu Yuan Guan Prof. Yusuke Yamauchi 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(44):19831-19836
Mesoporous core–shell nanostructures with controllable ultra-large open channels in their nanoshells are of great interest. However, soft template-directed cooperative assembly to mesoporous nanoshells with highly accessible pores larger than 30 nm, or even above 50 nm into macroporous range, remains a significant challenge. Herein we report a general approach for precisely tailored coating of hierarchically macro-/mesoporous polymer and carbon shells, possessing highly accessible radial channels with extremely wide pore size distribution from ca. 10 nm to ca. 200 nm, on diverse functional materials. This strategy creates opportunities to tailor the interfacial assembly of irregular mesostructured nanounits on core materials and generate various core–shell nanomaterials with controllable pore architectures. The obtained Fe,N-doped macro-/mesoporous carbon nanoshells show enhanced electrochemical performance for the oxygen reduction reaction in alkaline condition. 相似文献
96.
97.
The sunset diagram of λφ4 theory is evaluated numerically in cutoff scheme and a nonzero finite term(in accordance with dimensional regularization (DR) result) is found in contrast to published calculations. This findingdramatically reduces the critical couplings for symmetry breaking in the two-loop effective potential discussed in ourprevious work. 相似文献
98.
The structure, chemical composition, and magnetic properties of electrochemically deposited nanocrystalline Co-Ni-Fe films
were investigated using a number of techniques. A high saturation magnetic induction up to B
s
= 21 kG was attained. An enhancement of the saturation magnetization compared to the ideal anticipated one was revealed,
which correlated with the nonlinear behavior of the structural phase composition and lattice parameters with the change of
the composition.
The text was submitted by the authors in English. 相似文献
99.
100.
ON A PAIR OF NON-ISOMETRIC ISOSPECTRAL DOMAINS WITH FRACTAL BOUNDARIES AND THE WEYL-BERRY CONJECTURE
ONAPAIROFNONISOMETRICISOSPECTRALDOMAINSWITHFRACTALBOUNDARIESANDTHEWEYLBERRYCONJECTURESLEEMAN,B.D.CHENHUAManuscriptrec... 相似文献