Independance lineaire des valeurs des solutions transcendantes de certaines equations fonctionnelles

Sans résumé     

Induction asymetrique—II: Determination des configurations relatives de δ-amino β-hydroxyesters diastereoisomeres,obtenus par la reaction de reformatsky

Addition of Reformatsky reagents (R₁-CHZnBr-CO₂R) to three β-aminoketones, yields mixtures of threo and erythro diastereomeric aminohydroxyesters. The relative configurations of the first members of each series (R₁CH₃), were determined by chemical correlation. Those of higher homologues (R₁C₂H₅, iC₃H₇,tC₄H₉) are assigned by a study of their NMR spectra.     

CI calculations concerning the styrene cis-trans photoisomerization

Using minimal basis sets, the ionic and diradical excited states of the twisted styrene molecule have been calculated through extended CI, after appropriate SCF procedures. The lowest excited state is a diradical, and the photoisomerization should not involve the ionic state.     

Liquid chromatographic-mass spectrometric assay for simultaneous pyrimethamine and sulfadoxine determination in human plasma samples

We present a liquid chromatographic-mass spectrometric assay for the simultaneous determination of sulfadoxine and pyrimethamine in human plasma samples. Sample clean-up was achieved by adding acetonitrile for protein precipitation. Gradient elution in only 10 min resulted in high throughput capability. Tandem mass spectrometric detection in multiple reaction monitoring was used for quantification. The developed analytical approach was successfully validated and was applied in the pharmacokinetic evaluation of the bioavailability between two sulfadoxine/pyrimethamine formulations available on the Eastern African market, using a cross-over design.     

A Tverberg-type generalization of the Helly number of a convexity space

In 1966 H. Tverberg gave a far reaching generalization of the well-known classical theorem of J. Radon. In this paper a similar generalization of the classical Helly theorem is given and it is shown that among these two generalized theorems a relationship holds similar to a theorem proved by F.W. Levi in 1951. Also the generalized Helly theorem in the convex product and convex sum space are investigated.     

PAMAM dendrimers for efficient siRNA delivery and potent gene silencing

Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.