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991.
A high yield synthesis of alkyl azides is described from readily accessible alkyl bromides and sodium azide using a recyclable phase transfer catalyst, 18-crown-6 ether impregnated clay. 相似文献
992.
Eighteen new protic ionic liquids were synthesized in one step from five organic superbases and five commercially available fluorinated β-diketones. Physical properties of the ionic liquids, including thermal decomposition temperature were determined. Nine of the ionic liquids were examined as extraction media for La3+, with some very large distribution coefficients obtained. 相似文献
993.
Gibson HW Jones JW Zakharov LN Rheingold AL Slebodnick C 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(11):3192-3206
Complexation of anions, cations and even ion pairs is now an active area of investigation in supramolecular chemistry; unfortunately it is an area fraught with complications when these processes are examined in low polarity organic media. Using a pseudorotaxane complex as an example, apparent Ka2 values (=[complex]/{[salt]o?[complex]}{[host]o?[complex]}) for pseudorotaxane formation from dibenzylammonium salts ( 2 ‐X) and dibenzo‐[24]crown‐8 ( 1 , DB24C8) in CDCl3/CD3CN 3:2 vary with concentration. This is attributable to the fact that the salt is ion paired, but the complex is not. We report an equilibrium model that explicitly includes ion pair dissociation and is based upon activities rather than molar concentrations for study of such processes in non‐aqueous media. Proper analysis requires both a dissociation constant, Kipd, for the salt and a binding constant for interaction of the free cation 2 + with the host, Ka5; Ka5 for pseudorotaxane complexation is independent of the counterion (500 M ?1), a result of the complex existing in solution as a free cation, but Kipd values for the salts vary by nearly two orders of magnitude from trifluoroacetate to tosylate to tetrafluoroborate to hexafluorophosphate anions. The activity coefficients depend on the nature of the predominant ions present, whether the pseudorotaxane or the ions from the salt, and also strongly on the molar concentrations; activity coefficients as low as 0.2 are observed, emphasizing the magnitude of their effect. Based on this type of analysis, a method for precise determination of relative binding constants, Ka5, for multiple hosts with a given guest is described. However, while the incorporation of activity coefficients is clearly necessary, it removes the ability to predict from the equilibrium constants the effects of concentration on the extent of binding, which can only be determined experimentally. This has serious implications for study of all such complexation processes in low polarity media. 相似文献
994.
The replica exchange molecular dynamics (REMD) method has emerged as a standard approach for simulating proteins and peptides with rugged underlying free energy landscapes. We describe an extension to the original methodology--here termed umbrella-sampling REMD (UREMD)--that offers specific advantages in simulating peptide-peptide interactions. This method is based on the use of two dimensions in the replica cascade, one in temperature as in conventional REMD, and one in an umbrella sampling coordinate between the center of mass of the two peptides that aids explicit exploration of the complete association-dissociation reaction coordinate. To mitigate the increased number of replicas required, we pursue an approach in which the temperature and umbrella dimensions are linked at only fully associated and dissociated states. Coupled with the reweighting equations, the UREMD method aids accurate calculations of normalized free energy profiles and structural or energetic measures as a function of interpeptide separation distance. We test the approach on two families of peptides: a series of designed tetrapeptides that serve as minimal models for amyloid fibril formation, and a fragment of a classic leucine zipper peptide and its mutant. The results for these systems are compared to those from conventional REMD simulations, and demonstrate good convergence properties, low statistical errors, and, for the leucine zippers, an ability to sample near-native structures. 相似文献
995.
Christopher M. Rose Jason D. Russell Aaron R. Ledvina Graeme C. McAlister Michael S. Westphall Jens Griep-Raming Jae C. Schwartz Joshua J. Coon John E. P. Syka 《Journal of the American Society for Mass Spectrometry》2013,24(6):816-827
We describe and characterize an improved implementation of ETD on a modified hybrid linear ion trap-Orbitrap instrument. Instead of performing ETD in the mass-analyzing quadrupole linear ion trap (A-QLT), the instrument collision cell was modified to enable ETD. We partitioned the collision cell into a multi-section rf ion storage and transfer device to enable injection and simultaneous separate storage of precursor and reagent ions. Application of a secondary (axial) confinement voltage to the cell end lens electrodes enables charge-sign independent trapping for ion–ion reactions. The approximately 2-fold higher quadrupole field frequency of this cell relative to that of the A-QLT enables higher reagent ion densities and correspondingly faster ETD reactions, and, with the collision cell’s longer axial dimensions, larger populations of precursor ions may be reacted. The higher ion capacity of the collision cell permits the accumulation and reaction of multiple full loads of precursor ions from the A-QLT followed by FT Orbitrap m/z analysis of the ETD product ions. This extends the intra-scan dynamic range by increasing the maximum number of product ions in a single MS/MS event. For analyses of large peptide/small protein precursor cations, this reduces or eliminates the need for spectral averaging to achieve acceptable ETD product ion signal-to-noise levels. Using larger ion populations, we demonstrate improvements in protein sequence coverage and aggregate protein identifications in LC-MS/MS analysis of intact protein species as compared to the standard ETD implementation. Figure
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996.
Ryan Gianatassio Dr. Shuhei Kawamura Cecil L Eprile Dr. Klement Foo Jason Ge Dr. Aaron C. Burns Dr. Michael R. Collins Prof. Dr. Phil S. Baran 《Angewandte Chemie (International ed. in English)》2014,53(37):9851-9855
A simple method to convert readily available carboxylic acids into sulfinate salts by employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, including a key trifluoromethylcyclopropanation reagent, TFCS‐Na. The reactivity of six of these salts towards C? H functionalization was field‐tested using several different classes of heterocycles. 相似文献
997.
Visible‐Light‐Induced CO Release from a Therapeutically Viable Tryptophan‐Derived Manganese(I) Carbonyl (TryptoCORM) Exhibiting Potent Inhibition against E. coli 下载免费PDF全文
Jonathan S. Ward Dr. Jason M. Lynam Dr. James Moir Prof. Ian J. S. Fairlamb 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(46):15061-15068
The first visible‐light‐activated carbon‐monoxide‐releasing molecule (CO‐RM) to exhibit a potent effect against Escherichia coli is described. The easily prepared tryptophan‐derived manganese‐containing complex (TryptoCORM) released 1.4 moles of CO at 465 nm, and 2 moles at 400 nm. A comprehensive synthetic, mechanistic and microbiological study into the behaviour of TryptoCORM is reported. The complex is thermally stable (i.e., does not release CO in solution in the absence of light), shows low toxicity against mammalian cells and releases tryptophan on photoinduced degradation, all of which point to TryptoCORM being therapeutically viable. 相似文献
998.
Remarkable Enhancement of Enantioselectivity in the Asymmetric Conjugate Addition of Dimethylzinc to (Z)‐Nitroalkenes with a Catalytic [(MeCN)4Cu]PF6–Hoveyda Ligand Complex 下载免费PDF全文
Dr. Xingzhong Zeng Joe J. Gao Dr. Jinhua J. Song Dr. Shengli Ma Dr. Jean‐Nicolas Desrosiers Dr. Jason A. Mulder Dr. Sonia Rodriguez Dr. Melissa A. Herbage Dr. Nizar Haddad Dr. Bo Qu Dr. Keith R. Fandrick Dr. Nelu Grinberg Dr. Heewon Lee Dr. Xudong Wei Dr. Nathan K. Yee Dr. Chris H. Senanayake 《Angewandte Chemie (International ed. in English)》2014,53(45):12153-12157
An enantioselective copper‐catalyzed asymmetric conjugate addition of Me2Zn to (Z)‐nitroalkenes led to the formation of all‐carbon quaternary stereogenic centers with high stereoselectivity. The key features of the new method are the unprecedented use of [(MeCN)4Cu]PF6 in conjunction with the Hoveyda ligand L1 and the use of (Z)‐nitroalkene substrates so that undesired nitroalkene isomerization is minimized and enantioselectivity is enhanced dramatically. We also describe a novel, practical, and highly (Z)‐selective nitroalkene synthesis. 相似文献
999.
1000.
Jason F. Khoury Jiangang He Jonathan E. Pfluger Ido Hadar Mahalingam Balasubramanian Constantinos C. Stoumpos Rui Zu Venkatraman Gopalan Chris Wolverton Mercouri G. Kanatzidis 《Chemical science》2020,11(3):870
Subchalcogenides are uncommon, and their chemical bonding results from an interplay between metal–metal and metal–chalcogenide interactions. Herein, we present Ir6In32S21, a novel semiconducting subchalcogenide compound that crystallizes in a new structure type in the polar P31m space group, with unit cell parameters a = 13.9378(12) Å, c = 8.2316(8) Å, α = β = 90°, γ = 120°. The compound has a large band gap of 1.48(2) eV, and photoemission and Kelvin probe measurements corroborate this semiconducting behavior with a valence band maximum (VBM) of −4.95(5) eV, conduction band minimum of −3.47(5) eV, and a photoresponse shift of the Fermi level by ∼0.2 eV in the presence of white light. X-ray absorption spectroscopy shows absorption edges for In and Ir do not indicate clear oxidation states, suggesting that the numerous coordination environments of Ir6In32S21 make such assignments ambiguous. Electronic structure calculations confirm the semiconducting character with a nearly direct band gap, and electron localization function (ELF) analysis suggests that the origin of the gap is the result of electron transfer from the In atoms to the S 3p and Ir 5d orbitals. DFT calculations indicate that the average hole effective masses near the VBM (1.19me) are substantially smaller than the average electron masses near the CBM (2.51me), an unusual feature for most semiconductors. The crystal and electronic structure of Ir6In32S21, along with spectroscopic data, suggest that it is neither a true intermetallic nor a classical semiconductor, but somewhere in between those two extremes.Subchalcogenides are uncommon, and their chemical bonding results from an interplay between metal–metal and metal–chalcogenide interactions. 相似文献