全文获取类型
收费全文 | 299篇 |
免费 | 25篇 |
国内免费 | 1篇 |
专业分类
化学 | 288篇 |
力学 | 3篇 |
数学 | 16篇 |
物理学 | 18篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 10篇 |
2019年 | 10篇 |
2018年 | 3篇 |
2017年 | 1篇 |
2016年 | 15篇 |
2015年 | 19篇 |
2014年 | 14篇 |
2013年 | 12篇 |
2012年 | 24篇 |
2011年 | 22篇 |
2010年 | 9篇 |
2009年 | 8篇 |
2008年 | 22篇 |
2007年 | 22篇 |
2006年 | 22篇 |
2005年 | 12篇 |
2004年 | 15篇 |
2003年 | 13篇 |
2002年 | 18篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1975年 | 1篇 |
1966年 | 3篇 |
排序方式: 共有325条查询结果,搜索用时 15 毫秒
51.
A new synthetic entry to enantiopure cis-decahydroquinolines is reported. Endo and exo derivatives of cis-1-benzyl-2-(hydroxymethyl)octahydroindol-6-one ethylene acetal undergo ring enlargement upon treatment with TFAA and then Et3N (thermodynamic conditions) to give enantiopure 1-benzyl-3-hydroxydecahydroquinolin-7-one derivatives in 77 and 82% yield, respectively. For 2-(1-hydroxyethyl) analogues, the best synthetic result is obtained from the (2S,1'R) endo isomer, which under kinetic reaction conditions (MsCl, THF, -20 degrees C, then AgOAc at rt ) gives the expanded product in 54% yield. 相似文献
52.
53.
J Emile MH Werts F Artzner F Casanova O Emile JR Navarro F Meneau 《Journal of colloid and interface science》2012,383(1):124-129
Dry aqueous foams made of anionic surfactant (SDS) and spherical gold nanoparticles are studied by small angle X-ray scattering and by optical techniques. To obtain stable foams, the surfactant concentration is well above the critical micelle concentration. The specular reflectivity signal obtained on a very thin film (thickness 20 nm) shows that functionalized nanoparticles (17 nm typical size) are trapped within the film in the form of a single monolayer. In order to isolate the film behavior, investigations are made on a single film confined in a tube. The film thinning according to the ratio of functionalized nanoparticle and SDS micelles (1:1, 1:10, 1:100) is mainly governed by the structural arrangement of SDS micelles. In thick films, nanoparticles tend to form aggregates that disappear during drainage. In particular self-organization of nanoparticles (with different surface charge) inside the film is not detected. 相似文献
54.
Connell BJ Baleux F Coic YM Clayette P Bonnaffé D Lortat-Jacob H 《Chemistry & biology》2012,19(1):131-139
The HIV-1 envelope gp120, which features both the virus receptor (CD4) and coreceptor (CCR5/CXCR4) binding sites, offers multiple sites for therapeutic intervention. However, the latter becomes exposed, thus vulnerable to inhibition, only transiently when the virus has already bound cellular CD4. To pierce this defense mechanism, we engineered a series of heparan sulfate mimicking tridecapeptides and showed that one of them target the gp120 coreceptor binding site with μM affinity. Covalently linked to a CD4-mimetic that binds to gp120 and renders the coreceptor binding domain available to be targeted, the conjugated tridecapeptide now displays nanomolar affinity for its target. Using solubilized coreceptors captured on top of sensorchip we show that it inhibits gp120 binding to both CCR5 and CXCR4 and in peripheral blood mononuclear cells broadly inhibits HIV-1 replication with an IC(50) of 1 nM. 相似文献
55.
56.
Depression and anxiety disorders are widespread diseases, and they belong to the leading causes of disability and greatest burdens on healthcare systems worldwide. It is expected that the numbers will dramatically rise during the COVID-19 pandemic. Established medications are not sufficient to adequately treat depression and are not available for everyone. Plants from traditional medicine may be promising alternatives to treat depressive symptoms. The model organism Chaenorhabditis elegans was used to assess the stress reducing effects of methanol/dichlormethane extracts from plants used in traditional medicine. After initial screening for antioxidant activity, nine extracts were selected for in vivo testing in oxidative stress, heat stress, and osmotic stress assays. Additionally, anti-aging properties were evaluated in lifespan assay. The extracts from Acanthopanax senticosus, Campsis grandiflora, Centella asiatica, Corydalis yanhusuo, Dan Zhi, Houttuynia cordata, Psoralea corylifolia, Valeriana officinalis, and Withania somnifera showed antioxidant activity of more than 15 Trolox equivalents per mg extract. The extracts significantly lowered ROS in mutants, increased resistance to heat stress and osmotic stress, and the extended lifespan of the nematodes. The plant extracts tested showed promising results in increasing stress resistance in the nematode model. Further analyses are needed, in order to unravel underlying mechanisms and transfer results to humans. 相似文献
57.
Dr. Tao Shu Prof. Janine Cossy 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(43):11021-11029
This review highlights the recent achievements of iron- and cobalt-catalyzed enantioselective cross-couplings of halide derivatives with organometallic reagents for the construction of C-C bonds. Synthetic applications of enantioselective cross-couplings to natural products and biologically active compounds are also covered showing the power of these cross-couplings in organic synthesis. 相似文献
58.
Janine Kowalke Dr. Jörg Wagler Christine Viehweger Dr. Erica Brendler Prof. Edwin Kroke 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(36):8003-8006
Reactions of SiCl4 with R2PO(OH) (R=Me, Cl) yield compounds with six-fold coordinated silicon atoms. Whereas R=Me afforded the hexacoordinated tetra-cationic silicon complex [Si(Me2PO(OH))6]4+ with chloride counter-ions, R=Cl caused release of HCl with formation of a cyclic dimeric silicon complex [Si(Cl2PO(OH))(Cl2PO2)3(μ-Cl2PO2)]2 with bridging bidentate dichlorophosphates. 相似文献
59.
Dr. Camille Lecourt Sabrina Dhambri Khalil Yamani Dr. Guillaume Boissonnat Dr. Simon Specklin Dr. Etienne Fleury Karim Hammad Eric Auclair Serge Sablé Dr. Antonio Grondin Dr. Paola B. Arimondo Dr. François Sautel Dr. Georges Massiot Dr. Christophe Meyer Prof. Dr. Janine Cossy Dr. Geoffroy Sorin Dr. Marie-Isabelle Lannou Prof. Dr. Janick Ardisson 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(11):2745-2749
A strategy for the assembly of the entire carbon backbone of a stereoisomer of the antitumor marine natural product hemicalide has been investigated. The devised convergent approach relies on Horner–Wadsworth–Emmons and Julia–Kocienski olefination reactions for the construction of the C6=C7 and C34=C35 double bonds, respectively, an aldol reaction to create the C27−C28 bond, and a Suzuki–Miyaura cross-coupling as the endgame to form the C15−C16 bond. 相似文献
60.
Sarah HisChristophe Meyer Janine Cossy Gibert EmericAlfred Greiner 《Tetrahedron letters》2003,44(47):8581-8584
In the presence of trifluoroacetic acid, ketoxime benzyl carbonates undergo a Beckmann rearrangement to the corresponding amides. This reaction was translated to a solid support by immobilizing oximes in the form of mixed carbonates derived from hydroxymethylpolystyrene in order to produce a diversity of amides with high efficiency. 相似文献