Regioselective Synthesis of Allyl Trimethylsilanes from Allylic Halides

Treatment of an allylic halide 1 with a trimethylsilyl metal reagent affords either trans allyl trimethylsilane 4 or the regioisomeric allyl trimethylsilane 3 with proper choice of reaction conditions.     

Single versus multiple supplier sourcing strategies

Successful supply chain management necessitates an effective sourcing strategy to combat uncertainties in both supply and demand. In particular, supply disruption results in excessive downtime of production resources, upstream and downstream supply chain repercussions, and eventually a loss in the market value of the firm. In this paper we analyze single period, single product sourcing decisions under demand uncertainty. Our approach integrates product prices, supplier costs, supplier capacities, historical supplier reliabilities and firm specific inventory costs. A unique feature of our approach is the integration of a firm specific supplier diversification function. We also extend our analysis to examine the impact of minimum supplier order quantities. Our results indicate that single sourcing is a dominant strategy only when supplier capacities are large relative to the product demand and when the firm does not obtain diversification benefits. In other cases, we find that multiple sourcing is an optimal sourcing strategy. We also characterize a non-intuitive trade-off between supplier minimum order quantities, costs, and supplier reliabilities. Finally, we examine the robustness of our results through an extensive numerical analysis of the key parameters of our model.     

Patterns of breath support in projection of the singing voice

Recordings of the rib cage and abdominal motions and acoustic output were obtained from five professional opera singers during performance of an aria recorded with two levels of voice projection. The condition of greater projection resulted in a significant increase in the acoustic power in the frequency band 2-4 kHz, relative to the power in the 0-2 kHz band, and a decrease in the mean expiratory flow, implying a move to more efficient vocalization with the greater projection. Also, the condition of greater projection resulted in a larger rib cage, particularly in the lateral dimension, but only a small decrease in the abdominal lateral dimension, suggesting that the greater abdominal support required for a larger projection is obtained by increased activation of abdominal muscles acting medially.     

Terpenoids from the dorid nudibranch cadlina luteomarginata

Methanol extracts of intact specimens of Cadlina luteomarginata, collected in Howe Sound and Barkley Sound, British Columbia, have been shown to contain sesquitepenoids and a degraded terpenoid. Albicanol (2) and its acetate 1 possess the drimane skeleton. Furodysin (4) and microcionin-2 (5) and microcionin-2 (6) are furanosesquiterpenoids of sponge origin. Luteone (8), the degraded terpenoid, represents a new carbon skeleton.     

Sound generation and flow interaction of vortices with an airfoil and a flat plate in transonic flow

The mechanisms of sound generation and the kind of interaction of vortices with airfoils in an airflow are investigated. Experiments have been performed in stationary flow with vortices of a Kármán vortex street and in a shock tube flow with a starting vortex of a lifting airfoil. Depending on the dimensions of vortices and airfoils, their distance, and the flow Mach numbers, different kinds and amplitudes of upstream propagating steep sound waves occur.     

Fluorinated NAD as an affinity surfactant

Nicatinamide adenine dinucleotide (NAD) with an attached perfluoropolyether tail acts as an affinity surfactant in the extraction of the enzyme horse liver alcohol dehydrogenase (HLADH) from an aqueous medium into a fluorous solvent.     

The thermal decomposition of transition-metal complexes containing heterocyclic ligands: 2.Benzoxazole complexes

Enthalpies of the overall decomposition reactions

and of the intermediate reactions involving stepwise loss of ligand, L, where M is Mn, Co, Ni, Cu, or Cd, X is Cl or Br, and L is benzoxazole, 2-methylbenzoxazole, or 2,5-dimethylbenzoxazole have been measured by use of a differential scanning calorimeter. Specific heats of CoCl₂(2-methylbenzoxazole)₂, and CoBr₂(2-methylbenzoxazole)₂ are reported together with enthalpies of sublimation of CoCl₂(2-methylbenzoxazole)₂, CoBr₂(2-methyl-benzoxazole)₂, CoCl₂(2,5-dimethylbenzoxazole)₂ and CoBr₂(2,5-dimethylbenzoxazole)₂. Enthalpies of decomposition of benzoxazole complexes are found to be greater than those of the corresponding pyridine complexes, but less than those of the analogous benzothiazole complexes. However, the mean bond dissociation energies of the cobalt—nitrogen and cobalt—oxygen bonds in these complexes are all in the region 33±2 kcal mol^?.     

Synthesis of cationic water-soluble light-harvesting dendrimers

Four generations of phenylenefluorene (1F)- and phenylenebis(fluorene) (2F)-terminated polyamidoamine (PAMAM) dendrimers were synthesized by coupling activated esters with commercially available PAMAM precursors. Treatment of Boc-terminated pendant groups on the optically active units with 3 M HCl in dioxane yields cationic water-soluble dendrimers. Fluorescence resonance energy transfer (FRET) experiments with the cationic dendrimers as the donor and double stranded DNA containing a fluorescein label as the acceptor reveal cooperative optical behavior.     

The thermal decomposition of transition-metal complexes containing heterocyclic ligands: 3. Substituted pyridine complexes of cobalt

Enthalpies of the overall decomposition reactions CoX₂L₂(c) → CoX₂(c)+2L(g) and of the intermediate stepwise loss of ligand, L, where X is Cl or Br, and L is 3-chloropyridine, 3-bromopyridine, 2-chloropyridine, 2-bromopyridine, or 2-methoxypyridine have been measured by use of a differential scanning calorimeter. Enthalpies of sublimation of CoCl₂(3-chloropyridine)₂, CoBr₂(3-chloropyridine)₂, CoCl₂(3-bromopyridine)₂, CoCl₂(2-chloropyridine)₂, CoCl₂(2-bromopyridine)₂, CoBr₂(2-bromopyridine)₂, CoCl₂(2-methylpyridine)₂ and CoBr₂(2-methylpyridine)₂ have been determined. Values of the cobalt-nitrogen bond dissociation energies have been calculated. Specific heats of a number of the complexes are reported.