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61.
Parry MJ Alakoskela JM Khandelia H Kumar SA Jäättelä M Mahalka AK Kinnunen PK 《Journal of the American Chemical Society》2008,130(39):12953-12960
Siramesine (SRM) is a sigma-2 receptor agonist which has been recently shown to inhibit growth of cancer cells. Fluorescence spectroscopy experiments revealed two distinct binding sites for this drug in phospholipid membranes. More specifically, acidic phospholipids retain siramesine on the bilayer surface due to a high-affinity interaction, reaching saturation at an apparent 1:1 drug-acidic phospholipid stoichiometry, where after the drug penetrates into the hydrocarbon core of the membrane. This behavior was confirmed using Langmuir films. Of the anionic phospholipids, the highest affinity, comparable to the affinities for the binding of small molecule ligands to proteins, was measured for phosphatidic acid (PA, mole fraction of X(PA) = 0.2 in phosphatidylcholine vesicles), yielding a molecular partition coefficient of 240 +/- 80 x 10(6). An MD simulation on the siramesine:PA interaction was in agreement with the above data. Taking into account the key role of PA as a signaling molecule promoting cell growth our results suggest a new paradigm for the development of anticancer drugs, viz. design of small molecules specifically scavenging phospholipids involved in the signaling cascades controlling cell behavior. 相似文献
62.
Václav Janiš Jindřich Kolorenč 《The European Physical Journal B - Condensed Matter and Complex Systems》2016,89(7):170
One- and two-electron Green functions are simultaneously needed to determine the responsefunctions of the electron gas in a random potential. Reliable approximations must retainconsistency between the two types of Green functions expressed via Ward identities so thattheir output is compliant with macroscopic symmetries and conservation laws. Such aconsistency is not directly guaranteed when summing nonlocal corrections to the local(dynamical) mean field. We analyze the reasons for this failure and show how the full Wardidentity can generically be implemented in the diagrammatic approach to the vertexfunctions without breaking the analytic properties of the self-energy. We use thelow-energy asymptotics of the conserving two-particle vertex determining the singular partof response and correlation functions to derive an exact representation of the diffusionconstant in terms of Green functions of the perturbation theory. We then calculateexplicitly the leading vertex corrections to the mean-field diffusion constant due tomaximally-crossed diagrams. 相似文献
63.
Jani P. J. Turunen Tapani Venäläinen Sari Suvanto Tuula T. Pakkanen 《Journal of polymer science. Part A, Polymer chemistry》2007,45(17):4002-4012
Mesoporous aluminas with average pore sizes of 4.3–7.8 nm were prepared by anodization of an aluminum film (AAO), and by a sol–gel templating method (TPL). In addition to a commercial alumina and sulfated TPL, the aluminas were used as supports for cyclopentadienyl zirconocene dichloride (Cp2ZrCl2) and trimethyl(η5‐pentamethylcyclopentadienyl)zirconium (Cp*ZrMe3) and tested in the polymerization of ethylene. The metallocenes supported on the alumina prepared with the templating method and its sulfated modification exhibited polymerization activities of 440 and 350 kgPE/(molZr × h × bar), respectively, comparable to that obtained with silica‐supported metallocenes (390 kgPE/(molZr × h × bar)). The acid site distribution of the aluminas was studied with FTIR and temperature programmed desorption (TPD) of pyridine, and also the amount of medium and strong acid sites was determined gravimetrically from the adsorption of pyridine. Relative to the surface area, AAO with the highest amount of acid sites (2.10 μmolpy/m) adsorbed Cp2ZrCl2 and Cp*ZrMe3 the most. Study of the polymers' morphology with a scanning electron microscope revealed polyethylene nanofibers in all the polymer samples, also in those obtained from the reference polymerizations with homogeneous Cp2ZrCl2 and Cp*ZrMe3. This finding suggests that a catalyst support with a tubular pore structure is not a prerequisite for the formation of polymer nanofibers. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 4002–4012, 2007 相似文献
64.
Optical Review - We consider probing inhomogeneous waves in the near fields of metallic nanostructures with the aid of a dielectric V-shaped wedge connected to a waveguide. A geometrical model... 相似文献
65.
H. Ben Naceur I. Moussa O. Tottereau A. Rebey B. El Jani 《Physica E: Low-dimensional Systems and Nanostructures》2009,41(10):1779-1783
Thin InAs epilayers were grown on GaAs(1 0 0) substrates exactly oriented and misoriented toward [1 1 1]A direction by atmospheric pressure metalorganic vapor phase epitaxy. InAs growth was monitored by in situ spectral reflectivity. Structural quality of InAs layers were studied by using high-resolution X-ray diffraction. No crystallographic tilting of the layers with respect to any kind of these substrates was found for all thicknesses. This result is discussed in terms of In-rich growth environment. InAs layers grown on 2° misoriented substrate provide an improved crystalline quality. Surface roughness of InAs layers depend on layer thickness and substrate misorientation. 相似文献
66.
67.
We establish the basic analytic and geometric properties of quasiregular maps f: ω → X, where ω ? ? n is a domain and X is a generalized n-manifold with a suitably controlled geometry. Generalizing the classical Väisälä and Poletsky inequalities, our main theorem shows that the path family method applies to these maps. 相似文献
68.
Säily VM Ryhänen SJ Lankinen H Luciani P Mancini G Parry MJ Kinnunen PK 《Langmuir : the ACS journal of surfaces and colloids》2006,22(3):956-962
The properties of a novel disulfide-bond-containing gemini surfactant bis[N,N-dimethyl-N-hexadecyl-N-(2-mercaptoethyl)ammonium bromide] disulfide (DSP) were studied using a Langmuir balance, supported monolayers, differential scanning calorimetry, giant vesicles, and LUVs. In 150 mM NaCl the cmc for DSP was 7.5 microM whereas that of the monomer N,N-dimethyl-N-hexadecyl-N-(2-mercaptoethyl)ammonium bromide (MSP) was 12.1 microM. Both surfactants exhibited single endotherms upon DSC, with peak temperatures Tm at 21.7 and 20.1 degrees C for DSP and MSP, respectively. The endotherm for MSP was significantly broader indicating less cooperative melting. Both in monolayers and in vesicles reductive cleavage of the disulfide bond of DSP could be obtained by glutathione (GSH). For Langmuir films of DSP the addition of GSH into the subphase led to a decrease in surface pressure pi as well as surface dipole potential psi. Although the cleavage by GSH was significantly slower in the presence of a charge saturating concentration of DNA, it did not prevent the reaction. The resulting monomers detached from supported monolayers, leading to loss of affinity of the surface for DNA. Disruption of giant vesicles containing DSP within approximately 30 s following a local injection of GSH was observed, revealing membrane destabilization. 相似文献
69.
Saunavaara J Jokisaari J 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2006,180(1):58-62
The (129)Xe chemical shift of xenon dissolved in isotropic liquids is very sensitive to solvent density, which in turn is dependent on the sample temperature. Therefore, the (129)Xe chemical shift can be used as the basis of a thermometer for measuring actual sample temperatures in NMR experiments. Good accuracy can be achieved, but the thermometer is particularly useful in monitoring temperature stability. In the present case, carbon tetrachloride (CCl(4)), ethylbromide (C(2)H(5)Br), and deuterated chloroform (CDCl(3)) were chosen as solvents because of their large thermal expansion coefficient. 相似文献
70.