Internal energy content of n-butylbenzene, bromobenzene, iodobenzene and aniline molecular ions generated by two-photon ionization at 266 nm. A photodissociation study

A technique to investigate photodissociation kinetics on a nanosecond time scale has been devised for molecular ions generated by multiphoton ionization (MPI) using mass-analyzed ion kinetic energy spectrometry. The branching ratio or rate constant has been determined for the photodissociation of the n-butylbenzene, bromobenzene, iodobenzene, and aniline molecular ions generated by MPI at 266 nm. The ion internal energies have been estimated by comparing the measured kinetic data with the previous energy dependence data. The analysis has shown that only those molecular ions generated by two-photon ionization contribute to the photodissociation signals. Around half of the available energy has been found to remain as molecular ion internal energy in the two-photon ionization process. Copyright 1999 John Wiley & Sons, Ltd.     

Design,synthesis, molecular docking and in vitro evaluation of benzothiazole derivatives as 11β-hydroxysteroid dehydrogenase type 1 inhibitors

Molecular Diversity - 11-Beta hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates cortisol levels mainly in adipose, hepatic and brain tissues. There is a relationship between the high...     

Identification of the tension force in cables with insulators

Meccanica - The present paper explores two approaches which, based on the measurement of the two first natural frequencies, allow the identification of the tension force in cables with insulators....     

In Vitro and Computational Studies of Perezone and Perezone Angelate as Potential Anti-Glioblastoma Multiforme Agents

Glioblastoma multiforme (GBM) represents the most malignant type of astrocytoma, with a life expectancy of two years. It has been shown that Poly (ADP-ribose) polymerase 1 (PARP-1) protein is over-expressed in GBM cells, while its expression in healthy tissue is low. In addition, perezone, a phyto-compound, is a PARP-1 inhibitor with anti-neoplastic activity. As a consequence, in the present study, both in vitro and computational evaluations of perezone and its chemically related compound, perezone angelate, as anti-GBM agents were performed. Hence, the anti-proliferative assay showed that perezone angelate induces higher cytotoxicity in the GBM cell line (U373 IC₅₀ = 6.44 μM) than perezone (U373 IC₅₀ = 51.20 μM) by induction of apoptosis. In addition, perezone angelate showed low cytotoxic activity in rat glial cells (IC₅₀ = 173.66 μM). PARP-1 inhibitory activity (IC₅₀ = 5.25 μM) and oxidative stress induction by perezone angelate were corroborated employing in vitro studies. In the other hand, the performed docking studies allowed explaining the PARP-1 inhibitory activity of perezone angelate, and ADMET studies showed its probability to permeate cell membranes and the blood–brain barrier, which is an essential characteristic of drugs to treat neurological diseases. Finally, it is essential to highlight that the results confirm perezone angelate as a potential anti-GBM agent.     

Proportionally Modular Diophantine Inequalities and Full Semigroups

A proportionally modular numerical semigroup is the set of nonnegative integer solutions to a Diophantine inequality of the type ax mod b ≤ cx. We give a new presentation for these semigroups and we relate them with a type of affine full semigroups. Next, we describe explicitly the minimal generating system for the affine full semigroups we are considering. As a consequence, we obtain generating systems for proportionally modular numerical semigroups and we exhibit several families of these semigroups in terms of their generators. Finally, we use the concept of fundamental gap to study when a proportionally modular numerical semigroup is symmetric and we propose some open problems.     

One half of a pseudo-symmetric numerical semigroup

We prove that a numerical semigroup is irreducible if and onlyif it is one half of a pseudo-symmetric numerical semigroup.As a consequence we find that every numerical semigroup canbe obtained by dividing a pseudo-symmetric numerical semigroupby 4.     

Resonantly Interacting,Weakly Nonlinear Hyperbolic Waves. II. Several Space Variables

A uniformly valid asymptotic theory of resonantly interacting high-frequency waves for nonlinear hyperbolic systems in several space dimensions is developed. When applied to the equations of two-dimensional compressible fluid flow, this theory both predicts the geometric location of the new sound waves produced from the resonant interaction of sound waves and vorticity waves as well as yielding a simplified system which governs the evolution of the amplitudes. In this important special case, this system is two Burgers equations coupled by a linear integral operator with known kernel given by the vortex strength of the shear wave. Several inherently multidimensional assumptions for the phases are needed in this theory, and theoretical examples are given which delineate these assumptions. Furthermore, explicit necessary and sufficient conditions for the validity of the earlier noninteracting wave theory of Hunter and Keller are derived; these explicit conditions indicate that generally waves resonate and interact in several dimensions.     

Nonnegative elements of subgroups of

We give a method to compute all nonnegative integer solutions of a homogeneous system of linear equations. We use this method to provide an algorithm to compute all nonnegative integer solutions of homogeneous systems of equations having some of the equations in congruences.     

Gravity Waves in a Channel with a Rough Bottom

We derive effective equations for the surface elevation of gravity waves in a shallow channel with a rough bottom.