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991.
Determination of some hydroxycholesterols in human serum samples 总被引:4,自引:0,他引:4
B J Koopman J C van der Molen B G Wolthers J B Vanderpas 《Journal of chromatography. A》1987,416(1):1-13
The simultaneous determination of some hydroxycholesterols in human serum samples is described. The procedure is based on hydrolysis and extraction of these compounds in serum samples, followed by removal of especially cholesterol (making use of reversed-phase high-performance liquid chromatography) and derivatization of the purified compounds to their trimethylsilyl ethers and subsequent gas chromatography using flame ionization detection. Serum levels of 7 alpha-hydroxycholesterol, 7 beta-hydroxycholesterol and 26-hydroxycholesterol were determined in several groups of patients: normals, untreated patients suffering from cerebrotendinous xanthomatosis, patients suffering from cerebrotendinous xanthomatosis and treated with either chenodeoxycholic acid or cholic acid in an effective dose, patients suffering from cerebro-hepato-renal syndrome, patients suffering from hypercholesterolemia and treated with cholestyramine for prolonged periods and one patient presumed to be suffering from an inborn error of metabolism in bile acid synthesis. It can be concluded that the 7 alpha-hydroxycholesterol concentration in serum is a good parameter for establishing disorders involving the metabolic conversion of 7 alpha-hydroxycholesterol towards bile acids. In addition, 26-hydroxycholesterol levels in patients suffering from cerebrotendinous xanthomatosis are beyond detectable limits, even during treatment with bile acids in an effective dose, whereas in all other conditions this compound is substantially present. 相似文献
992.
993.
994.
R. A. Wind P. D. Majors K. R. Minard E. J. Ackerman D. S. Daly G. R. Holtom B. D. Thrall T. J. Weber 《Applied magnetic resonance》2002,22(2):145-158
Confocal fluorescence optical microscopy and magnetic resonance microscopy are each used to study live cells in a minimally invasive way. Both techniques provide complementary information. Therefore, by examining cells simultaneously with both methodologies, more detailed information is obtained than is possible with each microscope individually. In this paper two configurations of a combined confocal and magnetic resonance microscope are described. The first configuration is capable of studying large single cells or three-dimensional cell agglomerates, whereas the second configuration is designed for the investigation of monolayers of mammalian cells. In both cases the sample compartment is part of a temperature regulated perfusion system. Images obtained with the combined system are shown forXenopus laevis oocytes, model JB6 tumor spheroids, and a single layer of Chinese hamster ovary cells. Finally, potential applications of the combined microscope are discussed. 相似文献
995.
The qualitative behavior of buckled states of two different models of elastic beams is studied. It is assumed that random imperfections affect the governing nonlinear equations. It is shown that near the first critical value of the buckling load the stochastic bifurcation is described asymptotically by an algebraic equation whose coeffficients are Gaussian random variables. The corresponding asymptotic expansion for the displacement is to lowest order a Gaussian stochastic process.Work supported by NSF Grant No. DCR81-14726.Work supported by NSF Grant No. DMS87-01895. 相似文献
996.
997.
Technical cellulose-2.5-acetates (CA 2.5) were characterized regarding their carbohydrate composition in comparison to the raw material. The association of the CA 2.5 samples in acetone was studied by size exclusion chromatography (SEC) using various acetone grades and styrene divinylbenzene copolymer columns. In HPLC grade acetone with and without addition of 1% water up to three different pre-humps eluted in front of the main fraction of the polymer. The evaluation of the main peak by light scattering measurements resulted in high molar masses indicating that for these technical CA 2.5 samples even the main fraction is not dissolved without association. No pre-humps or association phenomena were observed after addition of 1 ppm LiBr to HPLC grade acetone or with p.a. grade acetone. In addition pre-hump enriched and pre-hump free fractions were isolated by fractionated precipitation. The carbohydrate composition of these fractions was determined and correlated with their association pattern in SEC investigations. 相似文献
998.
Summary. The perfectly matched layer (PML) is an efficient tool to simulate propagation phenomena in free space on unbounded domain.
In this paper we consider a new type of absorbing layer for Maxwell's equations and the linearized Euler equations which is
also valid for several classes of first order hyperbolic systems. The definition of this layer appears as a slight modification
of the PML technique. We show that the associated Cauchy problem is well-posed in suitable spaces. This theory is finally
illustrated by some numerical results. It must be underlined that the discretization of this layer leads to a new discretization
of the classical PML formulation.
Received May 5, 2000 / Published online November 15, 2001 相似文献
999.
Jürg Fröhlich Tai-Peng Tsai Horng-Tzer Yau 《Communications in Mathematical Physics》2002,225(2):223-274
We consider the nonlinear Hartree equation describing the dynamics of weakly interacting non-relativistic Bosons. We show
that a nonlinear M?ller wave operator describing the scattering of a soliton and a wave can be defined. We also consider the dynamics of a
soliton in a slowly varying background potential W(ɛx). We prove that the soliton decomposes into a soliton plus a scattering wave (radiation) up to times of order ɛ−1. To leading order, the center of the soliton follows the trajectory of a classical particle in the potential W(ɛx).
Received: 30 June 2000 / Accepted: 25 June 2001 相似文献
1000.
Ben J. Morris 《Random Structures and Algorithms》2002,21(2):135-146
We study the problem of sampling contingency tables (nonnegative integer matrices with specified row and column sums) uniformly at random. We give an algorithm which runs in polynomial time provided that the row sums ri and the column sums cj satisfy ri = Ω(n3/2m log m), and cj = Ω(m3/2n log n). This algorithm is based on a reduction to continuous sampling from a convex set. The same approach was taken by Dyer, Kannan, and Mount in previous work. However, the algorithm we present is simpler and has weaker requirements on the row and column sums. © 2002 Wiley Periodicals, Inc. Random Struct. Alg., 21: 135–146, 2002 相似文献