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21.
An electroswitchable and tunable biofuel cell based on the biocatalyzed oxidation of glucose is described. The anode consists of a Cu(2+)-poly(acrylic acid) film on which the redox-relay pyrroloquinoline quinone (PQQ) and the flavin adenine dinucleotide (FAD) cofactor are covalently linked. Apo-glucose oxidase is reconstituted on the FAD sites to yield the glucose oxidase (GOx)-functionalized electrode. The cathode consists of a Cu(2+)-poly(acrylic acid) film that provides the functional interface for the covalent linkage of cytochrome c (Cyt c) that is further linked to cytochrome oxidase (COx). Electrochemical reduction of the Cu(2+)-poly(acrylic acid) films (applied potential -0.5 V vs SCE) associated with the anode and cathode yields the conductive Cu(0)-poly(acrylic acid) matrixes that electrically contact the GOx-electrode and the COx/Cyt c-electrode, respectively. The short-circuit current and open-circuit voltage of the biofuel cell correspond to 105 microA (current density ca. 550 microA cm(-2)) and 120 mV, respectively, and the maximum extracted power from the cell is 4.3 microW at an external loading resistance of 1 kOmega. The electrochemical oxidation of the polymer films associated with the electrodes (applied potential 0.5 V) yields the nonconductive Cu(2+)-poly(acrylic acid) films that completely block the biofuel cell operation. By the cyclic electrochemical reduction and oxidation of the polymer films associated with the anode and cathode between the Cu(0)-poly(acrylic acid) and Cu(2+)-poly(acrylic acid) states, the biofuel cell performance is reversibly switched between "ON" and "OFF" states, respectively. The electrochemical reduction of the Cu(2+)-polymer film to the Cu(0)-polymer film is a slow process (ca. 1000 s) because the formation and aggregation of the Cu(0)-clusters requires the migration of Cu(2+) ions in the polymer film and their reduction at conductive sites. The slow reduction of the Cu(2+)-polymer films allows for the controlling of the content of conductive domains in the films and the tuning of the output power of the biofuel cell. The electron-transfer resistances of the cathodic and anodic processes were characterized by impedance spectroscopy. Also, the overall resistances of the biofuel cell generated by the time-dependent electrochemical reduction process were followed by impedance spectroscopy and correlated with the internal resistances of the cell upon its operation. 相似文献
22.
Carbon nanotubes (CNTs) revealing metallic or semiconductive properties depending on the folding modes of the nanotube walls represent a novel class of nanowires. Different methods to separate semiconductive CNTs from conductive CNTs have been developed, and synthetic strategies to chemically modify the side walls or tube ends by molecular or biomolecular components have been reported. Tailoring hybrid systems consisting of CNTs and biomolecules (proteins and DNA) has rapidly expanded and attracted substantial research effort. The integration of biomaterials with CNTs enables the use of the hybrid systems as active field-effect transistors or biosensor devices (enzyme electrodes, immunosensors, or DNA sensors). Also, the integration of CNTs with biomolecules has allowed the generation of complex nanostructures and nanocircuitry of controlled properties and functions. The rapid progress in this interdisciplinary field of CNT-based nanobioelectronics and nanobiotechnology is reviewed by summarizing the present scientific accomplishments, and addressing the future goals and perspectives of the area. 相似文献
23.
Itamar Willner Mazzi Lion-Dagan Shai Rubin Johann Wonner Franz Effenberger Peter Bäuerle 《Photochemistry and photobiology》1994,59(4):491-496
Abstract α-Chymotrypsin exhibits photoswitchable activities in an organic solvent after covalent modification of the protein backbone with thiophenefulgide active ester (2). The thiophenefulgide-modified α-chymotrypsin exhibits reversible photoisomerizable properties between states (3)-E and (3)-C. The modified α-chymotrypsin, where nine lysine residues are substituted by thiophenefulgide units, retains 60% of the activity of the native enzyme. The activities of thiophenefulgide-modified α-chymotrypsin toward esterification of N -acetyl-L-phenylalanine (4) by ethanol in cyclohexane are controlled by the configuration of the attached photoisomerizable component and by prior bioimprinting of the protein backbone with the reaction substrate (4). The esterification of (4) in cyclohexane using bioimprinted (3)-C is two-fold faster than in the presence of (3)-E. In the presence of a nonbioimprinted enzyme, esterification of (4) by (3)-C is five-fold faster than with (3)-E. The activity of bioimprinted (3)-E toward esterification of (4) is 4.5-fold higher than that of nonbioimprinted (3)-E. Switchable cyclic esterification of (4) is accomplished by sequential photoisomerization of the thiophenefulgide-modified α-chymotrypsin between states (3)-C and (3)-E. 相似文献
24.
Ivar Ugi Johannes Bauer Klemens Bley Alf Dengler Andreas Dietz Eric Fontain Bernhard Gruber Rainer Herges Michael Knauer Klaus Reitsam Natalie Stein 《Angewandte Chemie (International ed. in English)》1993,32(2):201-227
The topic of this article is the development and the present state of the art of computer chemistry, the computer-assisted solution of chemical problems. Initially the problems in computer chemistry were confined to structure elucidation on the basis of spectroscopic data, then programs for synthesis design based on libraries of reaction data for relatively narrow classes of target compounds were developed, and now computer programs for the solution of a great variety of chemical problems are available or are under development. Previously it was an achievement when any solution of a chemical problem could be generated by computer assistance. Today, the main task is the efficient, transparent, and non-arbitrary selection of meaningful results from the immense set of potential solutions—that also may contain innovative proposals. Chemistry has two aspects, constitutional chemistry and stereochemistry, which are interrelated, but still require different approaches. As a result, about twenty years ago, an algebraic model of the logical structure of chemistry was presented that consisted of two parts: the constitution-oriented algebra of be- and r-matrices, and the theory of the stereochemistry of the chemical identity group. New chemical definitions, concepts, and perspectives are characteristic of this logic-oriented model, as well as the direct mathematical representation of chemical processes. This model enables the implementation of formal reaction generators that can produce conceivable solutions to chemical problems—including unprecedented solutions—without detailed empirical chemical information. New formal selection procedures for computer-generated chemical information are also possible through the above model. It is expedient to combine these with interactive methods of selection. In this review, the Munich project is presented and discussed in detail. It encompasses the further development and implementation of the mathematical model of the logical structure of chemistry as well as the experimental verification of the computer-generated results. The article concludes with a review of new reactions, reagents, and reaction mechanisms that have been found with the PC-programs IGOR and RAIN. 相似文献
25.
Israel Goldberg Zafra Stein Koichi Tanaka Fumio Toda 《Journal of inclusion phenomena and macrocyclic chemistry》1991,10(1):97-107
The crystal structures of the 2,2-di(p-hydroxyphenyl)propane host and its 1:1 adducts withm-andp-cresol guests have been studied. The preferential complexation of this host withp-cresol overm-cresol is related to the opposite trend exhibited by 1,1-di(p-hydroxyphenyl)cyclohexane; both hosts can separate effectively the two cresols from their liquid mixture by crystalline inclusion. A plausible explanation of the different inclusion features is provided by examining the intermolecular association in the corresponding solids. The analysed structures are stabilized by strong and continuous H-bonding between the constituent entities along two dimensions, and by weak van der Waals forces along the third axis. The p-cresol complex of the title host reveals a unique arrangement within and a more efficient packing of the layered structure, and thus represents a more stable and less soluble crystal lattice than itsm-cresol analog.
Supplementary Data relating to this article are deposited with the British Library as Supplementary Publication No. SUP 82099 (8 pages). 相似文献
26.
Y. Stein 《Israel Journal of Mathematics》1995,89(1-3):301-319
LetP=x n +P n?1(y)x n?1+…+P 0(y),Q=x m +Q m?2(y)x m?2+…+Q 0(y) belong toK[x, y], whereK is a field of characteristic zero. The main result of this paper is the following: Assume thatP x Q y ?P y Q x =1. Then:*
- K[Q m?2(y), …,Q 0(y)]=K[y],
- K[P, Q]=K[x, y] ifQ=x m +Q k (y)x k +Q r (y)x r
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28.
A classical gas at equilibrium satisfies the locality conditionif the correlations between local fluctuations at a pair of remote small regions diminish in the thermodynamic limit. The gas satisfies a strong locality conditionif the local fluctuations at any number of remote locations have no (pair, triple, quadruple....) correlations among them in the thermodynamic limit. We prove that locality is equivalent to a certain factorizability condition on the distribution function. The analogous quantum condition fails in the case of a freeBose gas. Next we prove that strong locality is equivalent to the total factorizability of the distribution function, and thus (given Liourilles theorem) to the Maxwell Boltzmann distribution for an ideal gas.Dedicated to Professor Max Jammer on the occasion of his eightieth birthday. April 13. 1995. 相似文献
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