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11.
L. M. Khalilov M. É. Adler O. V. Shitikova M. S. Miftakhov G. A. Tolstikov 《Chemistry of Natural Compounds》1991,27(1):108-113
The diastereomeric effects on the13C NMR chemical shifts of thirteen epimeric pairs of 16-aryloxy-11-deoxyprostaglandins of the E1 and F1 series caused by the change in the configuration of the 15-hydroxy group, which are differential parameters for assigning epimers to the 15- and 15-stereochemical series, have been determined.For Communication (VIII), see [1].Institute of Chemistry, Bashkir Scientific Center, Urals Branch, Academy of Sciences of the USSR, Ufa. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 123–128, January–February, 1991. 相似文献
12.
Yan B Collins N Wheatley J Irving M Leopold K Chan C Shornikov A Fang L Lee A Stock M Zhao J 《Journal of combinatorial chemistry》2004,6(2):255-261
We have developed a high-throughput purification system to purify combinatorial libraries at a 50-100-mg scale with a throughput of 250 samples/instrument/day. We applied an accelerated retention window method to shorten the purification time and targeted one fraction per injection to simplify data tracking, lower QC workload, and simplify the postpurification processing. First, we determined the accurate retention time and peak height for all compounds using an eight-channel parallel LC/UV/MS system, and calculated the specific preparative HPLC conditions for individual compounds. The preparative HPLC conditions include the compound-specific gradient segment for individual compounds with a fixed gradient slope and the compound-specific UV or ELSD threshold for triggering a fraction collection device. A unique solvent composition or solvent strength was programmed for each compound in the preparative HPLC in order to elute all compounds at the same target time. Considering the possible deviation of the predicted retention time, a 1-min window around the target time was set to collect peaks above a threshold based on UV or ELSD detection. Dual column preparative instruments were used to maximize throughput. We have purified more than 500 000 druglike compounds using this system in the past 3 years. We report various components of this high-throughput purification system and some of our purification results. 相似文献
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The effect of changes of ionic strength on the partition of an analytically important weak acid between a variety of aqueous and immiscible organic phases has been studied with respect to new measurements on dithizone (3-mercapto-1,5-diphenylformazan) and di(p-tolyl)thiocarbazone. A linear relationship has been deduced between the pH at which 50% extraction takes place and Sr,o (the solubility of the reactant in the organic phase), and confirmed by measurements of pH, and Sr,o for a large number of organic solvents. The solubilities of the reagents in water, Sr, are also reported. The form of the relationship between pH and log D, and between pH and log Sr,o is the same whether a solution of dithizone consists of a single species or a mixture of thiol and thione forms in tautomeric equilibrium. 相似文献
16.
The determination of small amounts of long-chain tertiary alkylamines and quarternary ammonium salts
Bromocresol green has been investigated as an alternative to ammonium erdmannate for the absorptiometric determination of small amounts of long-chain alkylamines and quaternary ammonium salts in aqueous solution in a solvent extraction procedure. The molecular absorption coefficient of the reagent at 615 nm is about 3 times that of the erdmannate ion at 353 nm; visual methods of comparison are simplified by the blue colour of the bromocresol green anion The sensitivity of both the bromocresol green and the erdmannate method may be increased by stripping the coloured reagents into a small volume of aqueous solution. Both methods are free of interference from iron, but the present procedure has the disadvantage of a blank which depends both on the pH and on the concentration of excess reagent. 相似文献
17.
The structure of an unusual covalent adduct formed by thiol-activated neocarzinostatin chromophore (NCS-chrom) and a RNA-DNA hybrid having an overhang of four unpaired residues at the 3'-end of the RNA strand has been elucidated by MS and NMR spectroscopic analyses. Unlike previously characterized adducts formed by NCS-chrom on the sugar residue of the DNA target, this adduct has been found to be on one of the uracil bases in the RNA overhang. Covalent linkage is between C-6 of the post-activated NCS-chrom and C-5 of the uracil. A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-mercaptoethanol activation, to C-5 of the uracil at the U9 position of the RNA 11-mer, oxidation by dioxygen, reduction by the thiol, and subsequent dehydration is proposed for adduct formation. 相似文献
18.
C. Van den Abeele D. Ryckbosch G. De Meyer J. F. Dias L. Van Hoorebeke R. Van de Vyver J. -O. Adler K. Hansen L. Isaksson H. Ruijter P. Svensson B. Schröder 《Zeitschrift für Physik A Hadrons and Nuclei》1995,351(2):133-136
The values of the angle-integrated cross section for the decay to various low-lying states in39K following the40Ca(,) reaction at a mean photon energy of 60 MeV are reported on, together with the values of the reduced Legendre coefficientsa
i
. The40Ca(,gp) and40Ca(,n) reactions yield the same angular cross-section values and these agree with the corresponding RPA-calculations.Senior Research Associate NFWO 相似文献
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Strachan JD Adler H Alling P Ancher C Anderson H Anderson JL Ashcroft D Barnes CW Barnes G Batha S Bell MG Bell R Bitter M Blanchard W Bretz NL Budny R Bush CE Camp R Caorlin M Cauffman S Chang Z Cheng CZ Collins J Coward G Darrow DS DeLooper J Duong H Dudek L Durst R Efthimion PC Ernst D Fisher R Fonck RJ Fredrickson E Fromm N Fu GY Furth HP Gentile C Gorelenkov N Grek B Grisham LR Hammett G Hanson GR Hawryluk RJ Heidbrink W Herrmann HW Hill KW Hosea J Hsuan H Janos A Jassby DL Jobes FC 《Physical review letters》1994,72(22):3526-3529