Stereospecific synthesis of optically active phenylpropylene oxides

The stereospecific lithiation of diastereomeric phenylpropylene oxides has been studied as well as the trapping reaction with electrophiles. The reduction of the cis-alpha-benzoylpropylene oxide to give prevalently the anti-epoxy alcohol has been investigated as well.     

Solid phase synthesis of biohybrid block copolymers

A new versatile route to synthesise biohybrid block copolymers is presented in which an amine terminated polymer is attached to an aldehyde functionalised resin, from which in subsequent steps the desired peptide can be grown using standard procedures.     

Electric field effects on insulin chain-B conformation

The response of proteins to different forms of stress continues to be a topic of major interest, especially with the proliferation of electromagnetic devices conjectured to have detrimental effects on human health. In this paper, we have performed molecular dynamics simulations on insulin chain-B under the influence of both static and oscillating electric fields, ranging from 10(7) to 10(9) V/m. We have found that both variants have an effect on the normal behavior of the protein, with oscillating fields being more disruptive to the structure as compared to static fields of similar effective strength. The application of a static field had a stabilizing effect on the secondary structure, restricting the inherent flexibility that is crucial for insulin's biological activity.     

Asymptotic behavior at the boundary of a semiconductor device in two space dimensions

We study the analytic properties of the solution to a system of elliptic-parabolic equations simulating a semiconductor device. We describe the optimal regularity of the solution and its asymptotic behavior at the singular points of the problem.This paper is based on the thesis dissertation presented at the University of Chicago, Chicago, Illinois, in December 1989.     

Zur Konstruktion geschlitzter Inzidenzgruppen

In the first part a derivation method for incidence-groups is developed. The connections to the usual derivations of near-rings are shown in part 2 and examples are constructed. We characterize those finite slit incidence-groups with special affine kernel which are derivations of abelian incidence-groups. Applying these results to special classes of finite incidence-groups we show that there are 2-sided non-abelian finite incidence-groups with abelian affine kernel. The class of derivations of abelian finite incidence-groups contains all splitting a-2-sided incidence-groups with abelian kernel and no splitting kernel-2-sided non-2-sided incidence-group with abelian kernel. In the last part the a-2-sided incidence-groups are algebraically described.The results were partly communicated at the Conference on Geometry in March 1971 at the University of Waterloo, Ontario, Canada.