Rücktitelbild: C?H Activation Generates Period‐Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock (Angew. Chem. 24/2015)

The synthesis and functional analysis of KL001 derivatives, which are modulators of the mammalian circadian clock, are described. By using cutting‐edge C H activation chemistry, a focused library of KL001 derivatives was rapidly constructed, which enabled the identification of the critical sites on KL001 derivatives that induce a rhythm‐changing activity along with the components that trigger opposite modes of action. The first period‐shortening molecules that target the cryptochrome (CRY) were thus discovered. Detailed studies on the effects of these compounds on CRY stability implicate the existence of an as yet undiscovered regulatory mechanism.     

Thio-functionalised glucosinolates: unexpected transformation of desulfoglucoraphenin

Enzymatic desulfation of stable glucoraphenin affords desulfoglucoraphenin, which unexpectedly undergoes further transformations into cyclic nitrone-type derivatives.     

A hybrid genetic algorithm for the two-dimensional single large object placement problem

In the two-dimensional single large object placement problem, we are given a rectangular master surface which has to be cut into a set of smaller rectangular items, with the aim of maximizing the total value of the pieces cut. We consider the special case in which the items cannot be rotated and must be cut with their edges always parallel to the edges of the surface. We present new greedy algorithms and a hybrid genetic approach with elitist theory, immigration rate, heuristics on-line and tailored crossover operators. Extensive computational results for a large number of small and large benchmark test problems are presented. The results show that our approach outperforms existing heuristic algorithms.     

Time scale and freeze-out volume in the Xe + Cu reaction at 45 MeV/u

Correlations between Intermediate Mass Fragments were measured for the reaction Xe + Cu atE/A= 45 MeV/u. The velocity correlation function for central 3-fold events, depleted at small values of the relative coordinate, as typical for fast decay processes, reflects the mutual Coulomb repulsion between the emitted fragments. From the comparisons between a significant number of experimental observables and the predictions of the Berlin Multifragmentation Model, it appears that the data are compatible with a simultaneous multifragment emission.     

Element distributions for the reactions32S+100Mo,32S+93Nb and28Si+93Nb near the coulomb barrier

The element distributions for the reactions³²S+¹⁰⁰Mo,³²S+⁹³Nb, and²⁸Si+⁹³Nb have been measured atE/B～1.4. The correlations between the first moment of the measured distributions and TKEL are consistent with the predictions of the liquid drop potential energy surfaces showing the charge equilibration of the dinuclear systems. The measured second moments are compared with a recent systematics.     

A note on exact and heuristic algorithms for the identical parallel machine scheduling problem

A recent paper (Davidovi? et al., J. Heuristics, 18:549?C569, 2012) presented a bee colony metaheuristic for scheduling independent tasks to identical processors, evaluating its performance on a benchmark set of instances from the literature. We examine two exact algorithms from the literature, the former published in 1995, the latter in 2008 (and not cited by the authors). We show that both such algorithms solve to proven optimality all the considered instances in a computing time that is several orders of magnitude smaller than the time taken by the new algorithm to produce an approximate solution.     

Importance of volume limitation for tissue redox status measurements using nitroxyl contrast agents: a comparison of X-band EPR bile flow monitoring (BFM) method and 300 MHz in vivo EPR measurement

Methods proposed for in vivo redox status estimation, X-band (9.4 GHz) electron paramagnetic resonance (EPR) bile flow monitoring (BFM) and 300 MHz in vivo EPR measurement, were compared. The spin probe 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (carbamoyl-PROXYL) was utilized for both methods, due to its suitable lipophilicity. EPR signal decay of a nitroxyl spin probe in the bile flow and in the liver region (upper abdomen) of several rat groups with different selenium status were measured by both the BFM and the in vivo EPR method, respectively. The nitroxyl radical clearance measured with in vivo EPR method may be affected not only by the redox status in the liver but also by information from other tissues in the measured region of the rat. On the other hand, the time course of nitroxyl radical level in the bile flow of rats was found to be a reliable index of redox status. Measurement site and/or volume limitation, which was achieved by the BFM method in this paper, is quite important in estimating reasonable EPR signal decay information as an index of tissue/organ redox status.     

Electrical and material properties of hydrothermally grown single crystal (111) UO<Subscript>2</Subscript>

The semiconductor and optical properties of UO₂ are investigated. The very long drift carrier lifetimes, obtained from current–voltage I(V) and capacitance–voltage C(V) measurements, along with the well-defined optical properties provide little evidence of an abundance of material defects away from the surface region. Schottky barrier formation may be possible, but very much dependent on the choice of contact and surface stoichiometry and we find that Ohmic contacts are in fact favored. Depth resolved photoemission provided evidence of a chemical shift at the surface. Density functional theory, with the Heyd-Scuseria-Ernzerhof (HSE) functional, indicates a band gap of a 2.19 eV and an anti-ferromagnetic ground state. Ellipsometry measurements indicates at UO₂ is relatively isotropic with a band gap of approximately 2.0 eV band gap, consistent with theoretical expectations.