Synthesis and unusual photochemistry of a highly reactive pyrimidinedione

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Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan

In this work, a water-soluble supramolecular complex was synthesized in an aqueous suspension of betulin diacetate (BDA) and arabinogalactan (AG) upon microwave heating. Microwave heating allows reducing the time required for the complex formation, compared with conventional heating in a water bath. The specific effect of microwave irradiation on the initial reagents and preparation of a supramolecular complex was studied. In contrast to conventional heating, under microwave heating AG macromolecules may break into roughly equal fragments when the temperature increases up to 100 °C. A change in the surface morphology of BDA crystals under microwave heating of the suspension suggests that microwave irradiation facilitates the dissolution of BDA in water. It has been shown that the use of dimethylsulfoxide as a reaction medium for microwave heating led to a decrease in BDA content in the product due to the inclusion of DMSO into AG macromolecules. The BDA–AG complex was isolated from the microwave-heated aqueous solution, after water evaporation, as a thin amorphous film, which exhibited antitumor activity against Ehrlich ascites carcinoma cells and can be a promising material for pharmacological applications.     

On goodness-of-fit testing for ergodic diffusion process with shift parameter

A problem of goodness-of-fit test for ergodic diffusion processes is presented. In the null hypothesis the drift of the diffusion is supposed to be in a parametric form with unknown shift parameter. Two Cramer–von Mises type test statistics are studied. The first test uses the local time estimator of the invariant density, the second one uses the empirical distribution function. The unknown parameter is estimated via the maximum likelihood estimator. It is shown that the limit distribution of the two test statistics does not depend on the unknown parameter, thus both the tests are asymptotically parameter free. Some considerations on the consistency of the proposed tests and some simulation studies are also given.     

Fundamental domains for properly discontinuous affine groups

We construct a fundamental region for the action on the \(2d+1\) -dimensional affine space of some free, discrete, properly discontinuous groups of affine transformations preserving a quadratic form of signature \((d+1, d)\) , where \(d\) is any odd positive integer.     

Novel pincer complexes of Ag(I), coordination of toluene and their comparison with indium analogues

The bis(imino)pyridine scaffold provides for the synthesis and characterization of the unique Ag(I) pincer complexes [{ArN=CPh}(2)(NPh)]Ag(+)(OTf)(-) (Ar = 2,5-(t)Bu(2)C(6)H(3); 2,6-(i)Pr(2)C(6)H(3)). The similar covalent radii of Ag(I) and In(I), prompted a bonding comparison of these species with their In(I) analogues. Coordination of toluene to the Ag center revealed the stronger Lewis acidity of the metal site in these compounds relative to In(I) analogues.     

An EMF cell with a nitrogen solid electrolyte--on the transference of nitrogen ions in yttria-stabilized zirconia

The mobility and electrochemical activity of nitrogen inside and/or at the surface of ionic compounds is of fundamental, as well as of possibly practical, relevance. In order to better understand the role of nitrogen anions in solid electrolytes, we measured the transference number of nitrogen in yttria-stabilized zirconia (YSZ) by a concentration cell technique as a function of oxygen activity at different temperatures in the range of 1023 ≤T/K≤ 1123. YSZ doped with 1.9 wt% of N (YSZ:N) turned out to have an appreciable nitrogen transference number, which increased from 0 to 0.1 with decreasing oxygen activity in the range of -20 < log a(O(2)) < -14. The stability of N in YSZ:N, however, has yet to be elucidated under oxidizing conditions.     

Method for fractional solid-waste sampling and chemical analysis

Chemical characterization of solid waste is a demanding task due to the heterogeneity of the waste. This article describes how 45 material fractions hand-sorted from Danish household waste were subsampled and prepared for chemical analysis of 61 substances. All material fractions were subject to repeated particle-size reduction, mixing, and mass reduction until a sufficiently small but representative sample was obtained for digestion prior to chemical analysis. The waste-fraction samples were digested according to their properties for maximum recognition of all the studied substances. By combining four subsampling methods and five digestion methods, paying attention to the heterogeneity and the material characteristics of the waste fractions, it was possible to determine 61 substances with low detection limits, reasonable variance, and high accuracy. For most of the substances of environmental concern, the waste-sample concentrations were above the detection limit (e.g. Cd?>?0.001?mg?kg^?1, Cr?>?0.01?mg?kg^?1, Hg?>?0.002?mg?kg^?1, Pb?>?0.005?mg?kg^?1). The variance was in the range of 5–100%, depending on material fraction and substance as documented by repeated sampling of two highly different material fractions (‘Vegetable food’ and ‘Shoes, leather, etc.’). Statistical analysis showed for the ‘Vegetable food’ that the variance could not be attributed to a single step in the procedure, whereas in the case of ‘Shoes, leather, etc.’, the first coarse shredding was the main source of variance (20–85% of the overall variation). Only by increasing the sample size significantly can this variance be reduced. The accuracy and short-term reproducibility of the chemical characterization were good, as determined by the analysis of several relevant certified reference materials. Typically, six to eight different certified reference materials representing a range of concentrations levels and matrix characteristics were included. Based on the documentation provided, the methods introduced were considered satisfactory for characterization of the chemical composition of waste-material fractions.     

THE CONDENSED PHOSPHATES AS INHIBITORS OF THE ZINC-ENZYME CARBONIC ANHYDRASE II

The mobilization of the zinc ion from the zinc enzyme BCA II by the condensed phosphates pyrophosphate (PP), tripolyphosphate (TPP), and higher polyphosphate (HPP) induces the inhibition of the enzymatic activity. The chelating capacity increases with the ligand concentration and with the length of the polyphosphatic chain. The activity is restored when the polyphosphate is hydrolyzed, becoming incapable of chelating the zinc ion, which is able to reform the zinc enzyme.