Positive muon diffusion in mixed Nb‐hydrides, NbHxDy

Positive muons have been used to monitor the proton and deuteron mobilities in mixed, concentrated NbH_xD_y hydrides, with x+y= constant. The mobility of the muons decreases linearly with increasing D‐content, which is expected if the protons and the deuterons move in an uncorrelated fashion. Combined with other evidence which suggests that such correlations exist, the present observation may be interpreted as due to a destruction of a correlated motion of H’s or D’s in the vicinity of the muons. This revised version was published online in August 2006 with corrections to the Cover Date.     

Examining the mechanism of action of a kinesin inhibitor using stable isotope labeled inhibitors for cross-linking (SILIC)

It is difficult to determine a chemical inhibitor's binding site in multiprotein mixtures, particularly when high-resolution structural studies are not straightforward. Building upon previous research involving photo-cross-linking and the use of mixtures of stable isotopes, we report a method, Stable Isotope Labeled Inhibitors for Cross-linking (SILIC), for mapping a small molecule inhibitor's binding site in its target protein. In SILIC, structure-activity relationship data is used to design inhibitor analogues that incorporate a photo-cross-linking group along with either natural or 'heavy' stable isotopes. An equimolar mixture of these inhibitor analogues is cross-linked to the target protein to yield a robust signature for identifying inhibitor-modified peptide fragments in complex mass spectrometry data. As a proof of concept, we applied this approach to an ATP-competitive inhibitor of kinesin-5, a widely conserved motor protein required for cell division and an anticancer drug target. This analysis, along with mutagenesis studies, suggests that the inhibitor binds at an allosteric site in the motor protein.     

Conjugated Polymers-Based Ternary Hybrid toward Unique Photophysical Properties

The improvement of optical and optoelectronic properties of the individual poly [2-methoxy-5- (2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV), poly[2-methoxy-5-(3,7-dimethyl-octyloxy)-1,4-phenylenevinylene]–End capped with Dimethyl phenyl (OC1C10–PPV–DMP), and poly (9,9′-di- n -octylfluorenyl-2,7-diyl) (F8) was revealed by blending them in ternary hybrid with optimal ratio (F8/2 wt.% MEH-PPV/2 wt.% OC1C10–PPV–DMP). All individual and optimal ternary solutions were prepared via the solution-blending method followed by depositing them onto glass and ITO substrates using spin-coating technique. The semi-crystalline phase of the ternary hybrid and the strong mixing between the conjugated polymers were evidenced by observing the X-ray diffraction patterns that related to F8 into the hybrid diffractogram. The optical and optoelectronic properties of all prepared thin films were investigated in terms of absorption and emission spectra, Commission International d′Eclairage (CIE) coordinates, and current–voltage (I-V) characterizations. Emission peaks at the entire range of visible spectrum can be revealed from the ternary hybrid of the three individual conjugated polymers, producing white emission as evidenced from the emission spectrum and CIE coordinates of the hybrid. Among all fabricated organic light-emitting diodes (OLEDs) devices, the ternary hybrid-based-OLED revealed the best performance in terms of current and turn-on voltage.     

Abriß einer einheitlichen Theorie der Gamma- und der hypergeometrischen Funktionen

Ohne Zusammenfassung     

Mikrohärteuntersuchungen an Einkristallen der Verbindungen Tl3BX4, (B = V,Nb, Ta; X=S,Se)

Vickers microhardness measurements were performed on single crystals of compounds Tl₃BX₄ (B = V, Nb, Ta; X = S, Se). The anisotropy of the hardness on the (111)-plane was beyond the standard deviation. Besides the load-dependent Vickers hardness HV, the corrected, load-independent hardness HV_c was determined. Tl₃VS₄ showed the highest value of hardness (HV = 66 kp/mm² at 15 p load), the othe compounds differ only slightly in hardness.     

Ein Nomogramm zur Reduktion eines Resonators mit interner dünner Linse

Ohne ZusammenfassungDiese Arbeit wurde durch den Schweiz. Nationalfonds unterstützt.     

über die Verallgemeinerung eines Ergodensatzes von Dunford

Ohne Zusammenfassung