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21.
When food containing fat is treated by ionizing radiation, a group of 2-alkylcyclobutanones is formed. These components contain the same number of carbon atoms as their precursor fatty acids and the alkyl group is located in ring position 2. Thus, from palmitic acid 2-dodecylcyclobutanone is derived. To date, there is no evidence that the cyclobutanones occur in unirradiated food. Therefore, these components cannot be considered inherent to food, and for questions pertaining to risk assessment of irradiated food it would be advisable to determine the genotoxic and toxic potentials of cyclobutanones. Measurements of DNA damage in cells exposed to 2-dodecylcyclobutanone, employing the single cell microgel electrophoresis technique, have been carried out. In vitro experiments using rat and human colon cells indicate that 2-docylcyclobutanone in the concentration range of about 0.30 – 1.25 mg/ml induces DNA strand breaks in the cells. Simultaneously, a concentration related cytotoxic effect is observed as was determined by trypan blue exclusion. To which extent these in vitro findings are of relevancy for the in vivo human exposure situation needs to be investigated in further studies. In vivo tests in rats are in progress. 相似文献
22.
The reaction of phenyl lithium acetylide () with 2,6-diphenylpyrylium perchlorate () is solvent dependent. With diethyl ether as solvent, the isolated product differed from that previously reported and is reassingned as 2,6-diphenyl-4-phenylacetylenyl-4-pyran (). On the other hand, in THF the title compound () was obtained; its structure confirmed by single-crystal x-ray crystallography. 相似文献
23.
Marc Henry 《Journal of Cluster Science》2003,14(3):267-287
Among Achim Müller's prolific crystal structure database, we have selected two crystalline phases in order to perform a whole and complete characterization of water structure at the nanometer scale. The first chosen example involves the Na3(NH4)12[Mo57Fe6(NO)6O174(OH)3(H2O)24] 76H2O compound synthesized and characterized in 1994. Some very interesting yet unnoticed water clusters may be evidenced in the voids generated by the stacking of the polyanionic units. Among them, we have been able to characterized a pure water crown (H2O)18, a loose association of three strongly solvated ammonium ions [H3N–HOH2]+ mediated by two water dimers and one water molecule, a perfectly planar alternating six-member ring [(NH4)3(H2O)3]3+, a puckered chair-shaped hexagonal ring [(NH4)2(H2O)4]3+ and two triangular pyramidal water tetramers (H2O)4. It was also shown that the crown and the chair ring was involved through further hydrogen bonding into the formation of a quite novel supramolecular layer modeling the structure of water in contact with a polyelectrolyte. The second example involves the (gua)32[Mo132O372(H2O)72(SO4)10(H2PO2)20(gua)20]nH2O compound synthesized and characterized in 2002. Here, we provide for the first time a complete structural analysis of all the various hydrogen bond patterns encountered in this system. Among them we may cite, an intramolecular web covering the internal cavity, an intramolecular finite system involving the guanidinium cations and the nine-member ring pores of the Mo132 shell and a central pure water cluster of one hundred water molecules. In this last case, the evolution of the hydrogen bond strengths on a per H-bond basis or within supramolecular aggregates ([H2O]20, [H2O]40, and [H2O]100) is quantitatively studied from standpoints involving both geometry (H–OO bond angles distribution) and energy (partition functions). A survey of other crystalline phases involving water clusters is also presented. It is hoped that the study of these new clusters in a very next future will allow us to solve the well-known water puzzling behaviors. 相似文献
24.
Henry DJ Yiapanis G Evans E Yarovsky I 《The journal of physical chemistry. B》2005,109(36):17224-17231
This study examines the adhesion of graphite to functionalized polyester surfaces using a range of qualitative and quantitative measures of theoretical adhesion. Modifications to the polyester surfaces include the addition of hydroxyl, carboxyl, or fluorine substituents with coverages of 0.4 and 0.9 groups per nm(2). In each case, the introduction of substituents to the surface of the polyester was calculated to lead to reduced adhesion to graphite. Effects of surface relaxation on adhesion are studied by employing different simulation protocols. The theoretical results suggest one mechanism to reduce adhesion to carbonaceous solids is to increase atomic roughness using strongly hydrophilic or alternatively strongly hydrophobic substituents. 相似文献
25.
The ground (X (3)Sigma(-)) and first excited triplet (A (3)Pi) electronic states of diazocarbene (CNN) have been investigated systematically starting from the self-consistent-field theory and proceeding to the coupled cluster with single, double, and full triple excitations (CCSDT) method with a wide range of basis sets. While the linear X (3)Sigma(-) ground state of CNN has a real degenerate bending vibrational frequency, the A (3)Pi state of CNN is subject to the Renner-Teller effect and presents two distinct real vibrational frequencies along the bending coordinate. The bending vibrational frequencies of the A (3)Pi state were evaluated via the equation-of-motion coupled cluster (EOM-CC) techniques. The significant sensitivity to level of theory in predicting the ground-state geometry, harmonic vibrational frequencies, and associated infrared intensities has been attributed to the fact that the reference wave function is strongly perturbed by the excitations of 1pi-->3pi followed by a spin flip. At the highest level of theory with the largest basis set, correlation-consistent polarized valence quadruple zeta (cc-pVQZ) CCSDT, the classical X-A splitting (T(e) value) was predicted to be 68.5 kcal/mol (2.97 eV, 24 000 cm(-1)) and the quantum mechanical splitting (T(0) value) to be 69.7 kcal/mol (3.02 eV, 24 400 cm(-1)), which are in excellent agreement with the experimental T(0) values, 67.5-68.2 kcal/mol (2.93-2.96 eV, 23 600-23 900 cm(-1)). With the EOM-CCSD method the Renner parameter (epsilon) and averaged bending vibrational frequency (omega(2)) for the A (3)Pi state were evaluated to be epsilon=-0.118 and omega(2)=615 cm(-1), respectively. They are in fair agreement with the experimental values of epsilon=-0.07 and nu(2)=525 cm(-1). 相似文献
26.
The problem of defining N(E), the density of states, for molecular systems is discussed. It is shown that a numeric evaluation of N(E) is often only approximate, even for continuous data, and is not well defined for quantized systems. The application of the concept of density of states is discussed, particularly with regard to the RRKM theory of unimolecular reactions. The sum of states, W(E), and density of states curves are evaluated for several harmonic and anharmonic model systems and the results discussed in order to illustrate the foregoing considerations. 相似文献
27.
环境水中甲基对硫磷、对硫磷和辛硫磷农药残留的SPE-HPLC分析 总被引:29,自引:0,他引:29
采用离线固相萃取 (SPE)富集 -高效液相色谱(HPLC)分离和紫外分光光度法检测 ,对环境水中甲基对硫磷、对硫磷和辛硫磷3种有机磷农药进行分析;固相萃取用C18 萃取柱 ,用甲醇洗脱 ,高效液相色谱分离以Shim_PackCLCODS柱(150mm×4.6mmid,5μm)为分离柱 ,流动相为甲醇 -水(体积比70∶30) ,紫外检测波长为280nm;该法稳定可靠 ,回收率高 相似文献
28.
Dielectric spectroscopy is a powerful method that allows the study of the dynamics of polymers in a wide frequency range. The different regimes of the dielectric spectra can be observed and the dynamics of the primary and secondary relaxations can be found.In this work, the systems investigated included industrial and purified poly(lactic acid), PLA. This is an aliphatic polyester, one of the most important biocompatible and biodegradable material that has received increasing attention in the last 10 years.Thermal analyses indicated that the glass transition temperature of the polymer was about 320 K.The β relaxation was observed between −150 °C and −30 °C, depending on the measurement frequency (1 Hz-100 kHz), and was assigned to the secondary relaxation in the glassy state. We studied the changes that are connected with the water penetration in the polymer, and directly affect that relaxation process. Water molecules confined by polymer chains and in the polymer networks play an important role in the degradation of the matrix, and then we can observe the evolution of that degradation during some weeks, in a controlled humidity environment. It is accepted that water preferentially enters in the amorphous zones, but also affects the crystalline regions. It is observed a clear evolution of the relaxation activation energy during the degradation of the polymer.The dielectric relaxation results are complemented with molar mass measurements during the degradation process with time. 相似文献
29.
Stephen T. Ross Robert G. Franz James W. Wilson Richard A. Hahn Henry M. Sarau 《Journal of heterocyclic chemistry》1986,23(6):1805-1814
The three possible mono-O-methyl derivatives of 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepin-7,8-diol (SK&F 82526) ( 1 ) have been synthesized to facilitate the isolation and characterization of metabolites of this compound and for biological testing. The syntheses generally involved preparation of appropriately substituted benzaldehydes, conversion of these to phenylacetic acids and use of these to N-acylate arylethanolamines. The phenylacetamides thus formed were reduced to amines and these were deprotected and cyclized to the desired final products. In one case deprotection followed cyclization. These compounds were tested as activators of dopamine-sensitive adenylate cyclase (a measure of DA-1 agonist activity) and as renal vasodilators. All three O-methyl derivatives were much less potent than 1 in cyclase activation and as renal vasodilators. Weak inhibition of adenyl cyclase was also observed for all three compounds and one showed weak renal vasoconstrictor activity. Preliminary investigation of the metabolism of 1 disclosed that two of the three monomethoxy compounds were formed in trace amounts in the rat and the dog. In a related investigation, the trimethoxy derivative of 1 was subjected to acid-catalyzed hydrolysis conditions. The relative ease of cleavage of methoxy groups was 7 > > 4′ > 8. 相似文献
30.
Under Friedel-Crafts conditions, meso-tetraarylporphyrins give porphyrin spiro dimers in good yield. This reaction involves acylation, acid-catalyzed cyclization, and dimerization. A stable dimer possessing three additional six-membered rings could be isolated and its structure determined. By modifying the substrate and reagents, intermediates could be isolated and characterized. The reactivity of the substrates, the side-reactions, and the concentration requirements to form the dimers, all explain why this reaction remained apparently unexplored in the widely used meso-tetraarylporphyrin series. [reaction: see text] 相似文献