Microwave-assisted solution-phase synthesis and DART-mass spectrometric monitoring of a combinatorial library of indolin-2,3-dione schiff bases with potential antimycobacterial activity

A combinatorial library composed of eleven hydrazides A-K and eleven indolin-1,2-dione derivatives 1-11 has been designed to formally generate sublibraries of 22 mixtures, M(1)-M(22) comprising of 121 Schiff bases, A-K(1-11). The designed library has been synthesized by the solution-phase method and microwave-assisted synthetic techniques. The formation of individual compounds of each mixture was confirmed by Direct Analysis in Real Time (DART) as ionization technique connected to an Ion Trap as a mass detector. The synthesized mixtures were evaluated for their antimycobacterial activity against four Mycobacterium strains; M. intercellulari, M. xenopi, M. cheleneoi and M. smegmatis. Variable antimycobacterial activity was revealed with the investigated mixtures and maximum activity was shown by M(8), M(10), M(11), and M(15) with MIC values of 1.5, 3.1, 6.2 and 0.09 μg/mL, respectively. Application of the indexed method of analysis on these active mixtures revealed that compounds D(8), D(10) and D(11) may contribute to the activity of the tested mixtures.     

Synthesis of some new azole,pyrimidine, pyran,and benzo/naphtho[b]furan derivatives incorporating thiazolo[3,2‐a]benzimidazole moiety

Reaction of E‐3‐(N,N‐dimethylamino)‐1‐(3‐methylthiazolo[3,2‐a]benzimidazol‐2‐yl)prop‐2‐en‐1‐one ( 1 ) with some N‐nucleophiles, such as anilines 2a , 2b , 2c , 4‐amino‐N‐pyridin‐2‐yl‐benzenesulfonamide ( 4a ), 4‐amino‐N‐pyrimidin‐2‐yl‐benzenesulfonamide ( 4b ), hydrazine, hydroxylamine, thiourea, and guanidine afforded the corresponding arylaminoprop‐2‐en‐1‐one derivatives 3a , 3b , 3c , 5a , 5b , the pyrazole, isoxazole, pyrimidinethione and aminopyrimidine derivatives 7a , 7b , 9a , and 9b , respectively. The utility of compound 1 , as a versatile building block, for the synthesis of the pyranone 13 , benzo[b]furan 17a , and naphtho[1,2‐b]furan 17b was also explored via its reaction with 2‐benzamidoacetic acid ( 10 ), 1,4‐benzoquinone ( 14a ), and 1,4‐naphthoquinone ( 14b ), respectively. J. Heterocyclic Chem., (2011).     

Dynamic modelling and performance study of solar gas tunnel dryer

The work presented in this article focuses on the analysis and modelling of heat and mass transfers in the tunnel dryer during the drying of agricultural products. The main objective of this work is to establish a global modelling of the studied system based on the bond graph methodology. The pseudo-bond graph methodology was used in modelling the system. Such methodology was very suitable for this thermal process since it allows good management of the nonlinearity present in the system.

The thermal performance of the proposed dryer is analysed by solving the various energy balance equations. An application of drying tomatoes was achieved and a fair agreement was observed between predicted and experimental results.     

A high-harmonic generation source for seeding a free-electron laser at 38 nm

Direct seeding with a high-harmonic generation (HHG) source can improve the spectral, temporal, and coherence properties of a free-electron laser (FEL) and shall reduce intensity and arrival-time fluctuations. In the seeding experiment sFLASH at the extreme ultraviolet FEL in Hamburg FLASH, which operates in the self-amplified spontaneous emission mode (SASE), the 21st harmonic of an 800 nm laser is refocused into a dedicated seeding undulator. For seeding, the external light field has to overcome the noise level of SASE; therefore, an efficient coupling between seed pulse and electron bunch is mandatory. Thus, an HHG beam with a proper divergence, width, beam quality, Rayleigh length, pointing stability, single-shot pulse energy, and stability in the 21st harmonic is needed. Here, we present the setup of the HHG source that seeds sFLASH at 38.1 nm, the optimization procedures, and the necessary diagnostics.     

Time-Dependent Action in φ~6 Potential

The false vacuum decay in field theory from a coherently oscillating initial state is studied for φ6 potential. An oscillating bubble solution is obtained. The instantaneous bubble nucleation rate is calculated.     

A reliability study of springback on the sheet metal forming process under probabilistic variation of prestrain and blank holder force

This work deals with a reliability assessment of springback problem during the sheet metal forming process. The effects of operative parameters and material properties, blank holder force and plastic prestrain, on springback are investigated. A generic reliability approach was developed to control springback. Subsequently, the Monte Carlo simulation technique in conjunction with the Latin hypercube sampling method was adopted to study the probabilistic springback. Finite element method based on implicit/explicit algorithms was used to model the springback problem. The proposed constitutive law for sheet metal takes into account the adaptation of plastic parameters of the hardening law for each prestrain level considered. Rackwitz-Fiessler algorithm is used to find reliability properties from response surfaces of chosen springback geometrical parameters. The obtained results were analyzed using a multi-state limit reliability functions based on geometry compensations.     

Existence and controllability results for nondensely defined impulsive semilinear functional differential inclusions

In this paper, we shall establish sufficient conditions for the existence of integral solutions and extremal integral solutions for some nondensely defined impulsive semilinear functional differential inclusions in separable Banach spaces. We shall rely on a fixed point theorem for the sum of completely continuous and contraction operators. The question of controllability of these equations and the topological structure of the solutions set are considered too.     

Construction and stability of blowup solutions for a non-variational semilinear parabolic systemConstruction et stabilité de solutions explosives pour un système parabolique sémilinéaire non-variationel

We consider the following parabolic system whose nonlinearity has no gradient structure:

$\{\begin{array}{cc}{?}_{t}u=\mathrm{\Delta }u+|v{|}^{p?1}v,\hfill & {?}_{t}v=\mu \mathrm{\Delta }v+|u{|}^{q?1}u,\hfill \\ u(?,0)=u_0,\hfill & v(?,0)=v_0,\hfill \end{array}$

in the whole space ${\mathbb{R}}^N$, where $p,q>1$ and $\mu >0$. We show the existence of initial data such that the corresponding solution to this system blows up in finite time $T(u_0,v_0)$ simultaneously in u and v only at one blowup point a, according to the following asymptotic dynamics:

$\{\begin{array}{cc}\hfill & u(x,t)～\mathrm{\Gamma }{[(T?t)(1+\frac{b|x?a{|}^2}{(T?t)|\log ?(T?t)|})]}^{?\frac{(p+1)}{pq?1}},\hfill \\ \hfill & v(x,t)～\gamma {[(T?t)(1+\frac{b|x?a{|}^2}{(T?t)|\log ?(T?t)|})]}^{?\frac{(q+1)}{pq?1}},\hfill \end{array}$

with $b=b(p,q,\mu )>0$ and $(\mathrm{\Gamma },\gamma )=(\mathrm{\Gamma }(p,q),\gamma (p,q))$. The construction relies on the reduction of the problem to a finite dimensional one and a topological argument based on the index theory to conclude. Two major difficulties arise in the proof: the linearized operator around the profile is not self-adjoint even in the case $\mu =1$; and the fact that the case $\mu \ne 1$ breaks any symmetry in the problem. In the last section, through a geometrical interpretation of quantities of blowup parameters whose dimension is equal to the dimension of the finite dimensional problem, we are able to show the stability of these blowup behaviors with respect to perturbations in initial data.     

Combined approach of isotope mass balance and hydrological water balance methods to constrain the sources of lake water as exemplified on the small dimictic lake Silbersee,northern Germany

Stable isotopes of hydrogen and oxygen are often used for water balance calculations of lakes. We present an approach combining the lake water balance with an isotope mass balance to constrain the sources and sinks of the water of a small dimictic lake subjected to eutrophication. Meteorological and hydraulic data in combination with measured isotope signatures of the different water compartments enabled to assess the degree of surface water/groundwater interaction and the amount of overland flow into the lake. Groundwater could be excluded as a lake water source, as its water level was always below the lake water level. In the absence of a channelled inflow, precipitation and overland flow were the remaining options, whereby the latter was only active during periods of exceptionally high rainfall. While the groundwater signatures adjacent to the lake showed an influence of lake water, the lake water balance itself indicated that the associated volumetric water loss to groundwater is rather negligible. In the present case, only a combined assessment of hydrological and isotopic data allowed for an accurate characterization of the studied lake and a quantification of its water sources and sinks, highlighting the importance of using more than one methodological approach for such a purpose.