1,2-Benzothiazines VIII. A novel semmler-wolff type transformation of 2-methyl-2H-1,2-benzothiazin-4-one 1,1-dioxide oxime

Refluxing the oxime ( 1 ) of 2-methyl-2H-1,2-benzothiazin-4(3H)one 1,1-dioxide with tri-fluoroacetic acid or with boron trifluoride in acetic acid gives the corresponding N-acyl derivative ( 2 or 3) of 4-amino-2-methyl-2H-1,2-benzothiazin-3(4H)one 1,1-dioxide. This transformation appears to be related to the acid catalyzed conversion of α-tetralone oxime to α-naphthylamine.     

Lattice dynamics with second-neighbor interactions. III. Green's matrix

The theory of pth-order singular differential equations is adaptable to the study of the system of recurrence relations occurring in the problem of a one-dimensional chain with pth-neighbor interactions. By using Green's formula, a mapping is defined between the space V_n of eigenvectors to the dynamical matrix and the symplectic space V_2p of boundary conditions for the recurrence equations. The properties of the resolvent are obtained from an analysis of the solutions of a system of inhomogeneous equations and Green's matrix is constructed for the case of standard Sturm–Liouvilletype boundary conditions. The Weyl surface is discussed and its properties used for the construction of square summable sequences which in turn can be employed in expansion formulas. The generalization of Weyl's m-function in the second-order case (p = 1) becomes for p ≥ 2 a p × p matrix M (λ), where λ is a complex parameter. The imaginary part Im { M (λ)} is related to the spectral properties and serves as basis for the discussion of different concepts of spectral density for the normal modes of lattice dynamical problems. An important practical result is the equation M = ?ΨΦ_a valid in the limit point case, generalizing the corresponding second-order formula.     

Bisarylmaleimides & the Corresponding Indolocarbazoles as Kinase Inhibitors

Cyclin dependent kinases (CDKs) have recently raised considerable attention because of their central role in the regulation of cell cycle progression. A high incidence of genetic mutation of CDK substrates and deregulation of CDK modulators were found in a number of disease states, particularly in cancer. A novel series of unsymmetrical substituted indolocarbazoles were synthesized and their kinase inhibitory capability was evaluated in vitro. 6-Substituted indolocarbazoles were found to b…     

富含树皮体和半丝质体煤的液化反应性和~(13)C-核磁共振分析的研究

通过对富含树皮体的煤和半丝质体的煤进行液化研究和结构分析,探讨其液化产品的产率与结构参数之间的关系。富含树皮体的煤的氢含量和挥发分含量均高,H/C原子比也很高。13C-核磁共振分析表明,所有用煤都以芳香族碳为主。WEST样品的芳碳率最高,LP、CG和DHB样品中CH2基团碳含量高于CH3基团碳含量,且CH2基团碳含量高于其他三个样品。而P858样品中CH3基团碳含量高于CH2基团碳含量。液化结果表明,LP、CG和DHB有高的液化转化率和油收率。煤液化的油收率和煤结构中的CH2基团碳含量以及转化率和煤的芳碳率之间都存在明显的相关关系。因此,13C-核磁共振技术可以用来预测煤液化产品的收率。     

7-N,7'-N'-(1",2"-Dithianyl-3",6"-dimethylenyl)bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin

Dimeric alkylating agents that modify complementary DNA strands have engendered significant interest. We have prepared the novel dimeric mitomycin, 7-N,7'-N'-(1",2"-dithianyl-3",6"-dimethylenyl)bismitomycin C (9), in which the mitomycins are bridged by a dithiane unit. Dimer 9, like the clinically tested acyclic disulfides KW-2149 (3) and BMS-181174 (4), was designed to activate under nucleophilic and reductive conditions. Successive nucleophile-mediated disulfide cleavage transformations of 9 are expected to generate thiol species ideally positioned to render the two mitomycin systems vulnerable to nucleophilic attack and permit DNA interstrand cross-link formation. The dithiane linker, strategically positioned between the two mitomycins, distinguished 9 from 3 and 4. Nucleophilic activation of this cyclic disulfide permitted both activated mitomycins to remain tethered to one another. We report the synthesis of 9, and show that the nucleophile Et(3)P markedly enhances the activation and consumption of 9, compared with the reference compound 7-N, 7"-N'-(cyclohexanyl-trans-1",4"-dimethylenyl)bismitomycin C (27). We further demonstrated that provides higher levels of DNA interstrand cross-links than either the dimeric reference compounds, and 7-N,7-N'-(2",5"-dihydroxy-1",6"-hexanediyl)bismitomycin C (28), or the monomeric mitomycins, 1 and 3, when Et(3)P is added to solutions containing EcoRI-linearized pBR322 DNA.     

Parity-dependent rotational rainbows in D2-NO and He-NO differential collision cross sections

The (j', Omega', epsilon') dependent differential collision cross sections of D2 with fully state selected (j = 12, Omega = 12, epsilon = -1) NO have been determined at a collision energy of about 550 cm(-1). The collisionally excited NO molecules are detected by (1+1') resonance enhanced multiphoton ionization combined using velocity-mapped ion-imaging. The results are compared to He-NO scattering results and tend to be more forward scattered for the same final rotational state. Both for collisions of the atomic He and the molecular D2 with NO, scattering into pairs of rotational states with the same value of n = j' - epsilon epsilon'2 yields the same angular dependence of the cross section. This "parity propensity rule" remains present both for spin-orbit conserving and spin-orbit changing transitions. The maxima in the differential cross sections-that reflect rotational rainbows-have been extracted from the D2-NO and the He-NO differential cross sections. These maxima are found to be distinct for odd and even parity pair number n. Rainbow positions of parity changing transitions (n is odd) occur at larger scattering angles than those of parity conserving transitions (n is even). Parity conserving transitions exhibit-from a classical point of view-a larger effective eccentricity of the shell. No rainbow doubling due to collisions onto either the N-end or the O-end was observed. From a classical point of view the presence of a double rainbow is expected. Rotational excitation of the D2 molecules has not been observed.     

On representing a black box as a dynamical system

Necessary conditions are derived for a black box to be representable as a dynamical system governed by ordinary differential equations. Sufficiency of these conditions depends primarily on the set of inputs. It is shown that the conditions are indeed sufficient for the set of constant inputs and under suitable hypotheses for the set of smooth inputs. These conditions cannot be verified by a finite number of input-output observations.     

Quantum phase transition and emergent symmetry in a quadruple quantum dot system

We propose a system of four quantum dots designed to study the competition between three types of interactions: Heisenberg, Kondo, and Ising. We find a rich phase diagram containing two sharp features: a quantum phase transition (QPT) between charge-ordered and charge-liquid phases and a dramatic resonance in the charge liquid visible in the conductance. The QPT is of the Kosterlitz-Thouless type with a discontinuous jump in the conductance at the transition. We connect the resonance phenomenon with the degeneracy of three levels in the isolated quadruple dot and argue that this leads to a Kondo-like emergent symmetry from left-right Z2 to U(1).