Some remarks on variable range hopping—in particular in the quantum Hall regime

An expression for the heat conductivity _xx is derived in the effective medium approximation. Mott type formulas are obtained for _xx and the Peltier coefficient _xx . Using percolation theory in a three-dimensional system the Wiedemann-Franz ratio was found to depend on the temperature like . The Mott type formulas were evaluated in a similar way for a two-dimensional system in the quantum Hall regime within the high-field percolation model. In contrast to previous calculations of the high field hopping conductivity _xx , the results are fully consistent with the experimental data on _xx and the density of states at the Fermi level. Finally, _xx is estimated which together with _xx and _xy =ie ²/h(i=0,1,2,...), determines both thermopower coefficients _xx and _xy .Dedicated to Professor W. Brenig on the occasion of his 60th birthday     

Synthesis of enzyme-inhibitory phospholipid analogs II. Preparation of chiral 1-acyl-2-acylamido-2-deoxyglycerophosphorycholines from serine

A facile and efficient stereospecific route to the enzyme-inhibitory 2-amide analogs of phosphatidycholine is reported.     

Enantioselective analysis of venlafaxine and its active metabolites: A review on the separation methodologies

Venlafaxine (VFX) is a serotonin and norepinephrine reuptake inhibitor chiral drug used in therapy as an antidepressant in the form of a racemate consisting of R‐ and S‐VFX. The two enantiomers of VFX exhibit different pharmacological activities: R‐VFX inhibits both norepinephrine and serotonin synaptic reuptake, whereas S‐VFX inhibits only the serotonin one. R‐ and S‐VFX are metabolized in the liver to the respective R‐ and S‐O‐desmethylvenlafaxine (ODVFX), R‐ and S‐N‐desmethylvenlafaxine (NDVFX), and R‐ and S‐N,O‐didesmethylvenlafaxine (NODVFX). The pharmacological profile of ODVFX is close to that of VFX, whereas the other two chiral metabolites (NDVFX and NODVFX) have lower affinity for the receptor sites. The pharmacokinetics of the VFX enantiomers appear stereoselective, including the metabolism process. In the past 20 years, several studies describing the enantioselective analysis of R‐ and S‐VFX in pharmaceutical formulations and its chiral metabolites in biological matrices were published. These methods encompass liquid chromatography coupled with UV detection, mass spectrometry, or tandem mass spectrometry, and capillary electrophoresis. This paper reviews the published methods used for the determination of the individual enantiomers of VFX and its chiral metabolites in different matrices.     

Synthesis of phospholipids on a glyceric acid scaffold: design and preparation of phospholipase A2 specific substrates

Synthesis of a new series of phospholipid analogues to serve as activity-based probes of secretory phospholipase A₂ enzymes is reported. The synthesis is based upon (1) preparation of long-chain esters and amides of glyceric acid, followed by (2) regioselective derivatization of the diol function of the molecule to achieve phosphorylation at the primary hydroxyl group, and to introduce the incipient sn-2-ester group of the target compounds. The sequence has been shown to allow incorporation of fluorescent, paramagnetic, and redox-active reporter groups, leading to phospholipid analogues applicable to detect and measure enzyme activity, to develop highly specific, real-time spectroscopic assay of phospholipase A₂ enzymes, as well as to track the metabolic fate of the hydrolysis products. The synthetic method has a great deal of flexibility to open the way to the design and synthesis of activity-probes for other phospholipid metabolizing enzymes as well.     

Flow-driven Surface Instabilities of Tubular Chitosan Hydrogel

Spatial structures break their symmetry under the influence of shear stress arising from fluid flow. Here, we present surface instabilities appearing on chitosan tubes when an acidic solution of chitosan with various molecular weight is injected into a pool of sodium hydroxide solution. At slow flow rates wrinkle-to-fold transition takes place along the direction of the flow yielding a banded structure. For greater injection rates we observe coexisting modes of wrinkles and folds which are stabilized to periodic wrinkles when the alkaline concentration is increased. The instabilities are characterized by the scaling laws of the pattern wavelength and amplitude with the tube characteristics. Our experimental adaptation of mechanical instabilities provides a new in situ method to create soft biomaterials with the desired surface morphology without the use of any prefabricated templates.     

Zur Quantentheorie der Transportprozesse im Magnetfeld. II

Applying Kubo's formulae and damping theoretical arguments the electric, thermoelectric and thermal transport coefficients for a system of free and independent electrons and fixed scatterers in the presence of an external magnetic field are calculated. Assumingδ-type scatterers it is shown that in the quantum regionkT?ω?ζ the Wiedemann-Franz law holds for the oscillating symmetric conductivities, whereas in the case of the antisymmetric ones quantum mechanical deviations from this law occur. For strong magnetic fields and arbitrary scattering potential the symmetric transversal transport coefficients can be expressed by Titeica type formulae.     

On the quantum limit behaviour of the transverse magnetoresistance

Damping theoretical calculation of the transverse magnetoresistance in the quantum limit yields an approximate power law ρ ∝ B^α with α = 3 for short range and α = 1 for long range impurities — in agreement with experimental results.     

Cyclodextrins in innovative engineering tools for risk-based environmental management

Experimental results, which may serve as basis for innovative applications of cyclodextrins (CDs) in environmental technologies, are presented here. Some newly developed CD-aided tools are used in sampling, measuring the concentration or testing the effect of contaminants in water and soil. The innovative methods such as the bacterial bioassays with CD-increased sensitivity or the CD-filled absorptive samplers for air and water sampling are utilised in environmental exposure, hazard and risk assessment. Technological developments aim the reduction of the risk of chemical substances in waters and soils. CD-aided environmental remediation is introduced through examples for the elimination of organic contaminants from water by CD-filters, and for the enhancement of the mobility and availability of soil contaminants in this way increasing the efficiency of soil remediation by water extraction, chemical oxidation, biodegradation, etc.     

Powerful arithmetic progressions

We give a complete characterization of so-called powerful arithmetic progressions, i.e. of progressions whose kth term is a kth power for all k. We also prove that the length of any primitive arithmetic progression of powers can be bounded both by any term of the progression different from 0 and ±1, and by its common difference. In particular, such a progression can have only finite length.     

Conductance noise spectrum of mesoscopic systems

We investigate the shape as well as the size- and temperature-dependence of the conductance noise spectrum of a small system containing electrons and both fixed and mobile scatterers. If the number of mobile scatterers within a phase-coherent region is sufficiently large, the temporal variation of the conductance can be viewed as a random walk process limited by the universal conductance fluctuations, resulting in a practically Lorentzian power spectrum. We discuss the conditions under which the noise spectrum of a system consisting of many phase-coherent regions is either Lorentzian or 1/f-like. The temperature-dependence of the power spectrum is determined by the hopping mechanism and the variation of the phase breaking length. As a function of temperature the spectrum satisfies power law scaling relations with exponents depending on the dimension and the temperature range; the spectral intensity can both increase and decrease with decreasing temperature.