Influence of crosslinker identity and position on gas-phase dissociation of lys-lys crosslinked peptides

A systematic study of the dissociation patterns of crosslinked peptides analyzed by tandem mass spectrometry is reported. A series of 11-mer peptides was designed around either a polyalanine or polyglycine scaffold with arginine at the C terminus. One or two lysine residues were included at various locations within the peptides to effect inter- or intra-molecular crosslinking, respectively. Crosslinked species were generated with four commonly used amine-specific chemical crosslinking reagents: disuccinimidyl suberate (DSS), disuccinimidyl tartarate (DST), dithiobis(succinimidylpropionate) (DSP), and disuccinimidyl glutarate (DSG). The influence of precursor charge state, location of crosslink, and specific crosslinking reagent on the MS/MS dissociation pattern was examined. Observed trends in the dissociation patterns obtained for these species will allow for improvements to software used in the automated interpretation of crosslinked peptide MS/MS data.     

LMI-based stabilization of a class of fractional-order chaotic systems

Based on the theory of stabilization of fractional-order LTI interval systems, a simple controller for stabilization of a class of fractional-order chaotic systems is proposed in this paper. We consider the structure of the chaotic systems as fractional-order LTI interval systems due to the limited amplitude of chaotic trajectories. We introduce a simple feedback controller for the interval system and then, based on a recently established theorem for stabilization of interval systems, we reach to a linear matrix inequality (LMI) problem. Solving the LMI yields an appropriate decoupling feedback control law which suffices to bring the chaotic trajectories to the origin. Several illustrative examples are given which show the effectiveness of the method.     

The effect of real viscosity on the heat transfer of water based Al2O3 nanofluids in a two-sided lid-driven differentially heated rectangular cavity

The heat transfer and fluid flow behavior of water based Al₂O₃ nanofluids are numerically investigated inside a two-sided lid-driven differentially heated rectangular cavity. Physical properties which have major effects on the heat transfer of nanofluids such as viscosity and thermal conductivity are experimentally investigated and correlated and subsequently used as input data in the numerical simulation. Transport equations are numerically solved with finite volume approach using SIMPLEC algorithm. It was found that not only the thermal conductivity but also the viscosity of nanofluids has a key role in the heat transfer of nanofluids. The results show that at low Reynolds number, increasing the volume fraction of nanoparticles increases the viscosity and has a deteriorating effect on the heat transfer of nanofluids. At high Reynolds number, the increase in the viscosity is compensated by force convection and the increase in the volume fraction of nanoparticles which results in an increase in heat transfer is in coincidence with experimental results.     

Stability analysis of Caputo fractional-order nonlinear systems revisited

In this paper stability analysis of fractional-order nonlinear systems is studied. An extension of Lyapunov direct method for fractional-order systems using Bihari’s and Bellman–Gronwall’s inequality and a proof of comparison theorem for fractional-order systems are proposed.     

Investigation of DKP equation for spin-zero system in the presence of Gödel-type background space-time

This paper contains a discussion of a relativistic spin-0 system in the presence of a Gödel-type background space-time. The Duffin–Kemmer–Petiau (DKP) equation in the presence of a Gödel-type background space-time is studied in detail. After a derivation of the final form of this equation in the considered framework, free spin-0 particles have been studied.     

New ordered MAX phase Mo_2 TiAlC_2: Elastic and electronic properties from first-principles

First-principles computation on the basis of density functional theory(DFT) is executed with the CASTEP code to explore the structural, elastic, and electronic properties along with Debye temperature and theoretical Vickers' hardness of newly discovered ordered MAX phase carbide Mo_2TiAlC_2. The computed structural parameters are very reasonable compared with the experimental results. The mechanical stability is verified by using the computed elastic constants. The brittleness of the compound is indicated by both the Poisson's and Pugh's ratios. The new MAX phase is capable of resisting the pressure and tension and also has the clear directional bonding between atoms. The compound shows significant elastic anisotropy. The Debye temperature estimated from elastic moduli(B, G) is found to be 413.6 K. The electronic structure indicates that the bonding nature of Mo_2TiAlC_2 is a mixture of covalent and metallic with few ionic characters. The electron charge density map shows a strong directional Mo–C–Mo covalent bonding associated with a relatively weak Ti–C bond.The calculated Fermi surface is due to the low-dispersive Mo 4d-like bands, which makes the compound a conductive one.The hardness of the compound is also evaluated and a high value of 9.01 GPa is an indication of its strong covalent bonding.     

Rashba Effect in Presence of Time-Dependent Interaction

Rashba effect in presence of a time-dependent interaction has been considered.Then time-evolution of such a system has been studied by using Lewis–Riesenfeld dynamical invariant and unitary transformation method.So appropriate dynamical invariant and unitary transformation according the considered system have been constructed as well as some special cases have come into this article which are common in physics.     

Voltammetric sensor for simultaneous determination of ascorbic acid,acetaminophen, and tryptophan in pharmaceutical products

A novel carbon paste electrode modified with carbon nanotubes and 5-amino-2′-ethyl -biphenyl-2-ol was fabricated. The electrochemical study of the modified electrode, as well as its efficiency for electrocatalytic oxidation of ascorbic acid (AA), is described. The electrode was employed to study the electrocatalytic oxidation of AA, using cyclic voltammetry, chronoamperometry, and square-wave voltammetry (SWV) as diagnostic techniques. It has been found that the oxidation of AA at the surface of modified electrode occurs at a potential of about 250 mV less positive than that of an unmodified carbon paste electrode. SWV exhibits a linear dynamic range from 2.0?×?10^?7 to 5.0?×?10^?4 M and a detection limit of 1.0?×?10^?7 M for AA. In addition, this modified electrode was used for simultaneous determination of AA, acetaminophen (AC), and tryptophan (TRP). Finally, the modified electrode was used for determination of AA, AC, and TRP in pharmaceutical products.     

Evaluation of essential oils for maintaining postharvest quality of Thompson seedless table grape

The effects of postharvest spraying of essential oils from sweet basil (Ocimum basilicum), fennel (Foeniculum vulgare), summer savory (Satureja hortensis) and thyme (Thymus vulgaris) on fungal decay and quality parameters of the 'Thompson seedless' table grape stored at 0?±?1°C for 60 days were evaluated. Results showed that the essential oils, especially of thyme and fennel, have a good inhibitory effect on the development of fungal decay in Thompson table grapes. In addition, essential oils reduced weight loss, berry and rachis browning and had no considerable adverse effect on the flavour of the fruits. GC-MS analysis showed that the main compounds identified in sweet basil, fennel, summer savory and thyme oils are linalool (65.25%), trans-anethole (64.72%), carvacrol (54.14%) and β-ocimene (12.62%), respectively. Therefore, these essential oils have good potential for use as an alternative to synthetic fungicides for the preservation and storage of table grapes.     

Effect of Satureja khuzestanica essential oil on oxidative stability of sunflower oil during accelerated storage

In this study, the application of various concentrations (0.02%, 0.04%, 0.06% and 0.08%) of Satureja khuzestanica essential oil (EO) was examined on the oxidative stability of sunflower oil and compared to butylated hydroxyanisole (BHA) during storage at 60°C. Gas chromatography (GC) and GC-mass spectrometry analyses of the oils revealed that carvacrol (87.7%) was the major component of EO. Peroxide value and anisidine value measurements in sunflower oil showed that all concentrations of EO had antioxidant effects in comparison to BHA. Oil samples supplemented with EO concentration of 0.08% were the most stable during storage (p?相似文献