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101.
Wenhan Xu Michelle M. S. Lee Jing‐Jun Nie Zhihan Zhang Ryan T. K. Kwok Jacky W. Y. Lam Fu‐Jian Xu Dong Wang Ben Zhong Tang 《Angewandte Chemie (International ed. in English)》2020,59(24):9610-9616
Photodynamic therapy (PDT) has long been shown to be a powerful therapeutic modality for cancer. However, PDT is undiversified and has become stereotyped in recent years. Exploration of distinctive PDT methods is thus highly in demand but remains a severe challenge. Herein, an unprecedented 1+1+1>3 synergistic strategy is proposed and validated for the first time. Three homologous luminogens with aggregation‐induced emission (AIE) characteristics were rationally designed based on a simple backbone. Through slight structural tuning, these far‐red/near‐infrared AIE luminogens are capable of specifically anchoring to mitochondria, cell membrane, and lysosome, and effectively generating reactive oxygen species (ROS). Notably, biological studies demonstrated combined usage of three AIE photosensitizers gives multiple ROS sources simultaneously derived from several organelles, which gives superior therapeutic effect than that from a single organelle at the same photosensitizers concentration. This strategy is conceptually and operationally simple, providing an innovative approach and renewed awareness of improving therapeutic effect through three‐pronged PDT. 相似文献
102.
The microwave spectra of the natural substance coumarin, a planar aromatic molecule with the specific scent of maibowle, a popular fruit punch served in spring and early summer, were recorded using a molecular jet Fourier transform microwave spectrometer working in the frequency range from 4.0 to 26.5 GHz. The rotational constants and centrifugal distortion constants were determined with high precision, reproducing the spectra to experimental accuracy. The spectra of all singly-substituted 13C and 18O isotopologues were observed in their natural abundances to determine the experimental heavy atom substitution rs and semi-experimental equilibrium reSE structures. The experimental bond lengths and bond angles were compared to those obtained from quantum chemical calculations and those of related molecules reported in the literature with benzene as the prototype. The alternation of the C−C bond lengths to the value of 1.39 Å found for benzene reflects the localization of π electrons in coumarin, where the benzene ring and the lactone-like chain −CH=CH−(C=O)−O− are fused. The large, negative inertial defect of coumarin is consistent with out-of-plane vibrations of the fused rings. 相似文献
103.
The system studied here principally is γ-APS + BADGE (γ-aminopropyltriethoxysilane + diglycidyl ether of bisphenol A). The reaction takes place even at −20°C. It is first the epoxy-amine autocatalytic second-order reaction, but we also have a cross-linking reaction which needs more time and higher temperature. The behaviour of this system is the same as γ-APS-PGE (phenylglycidyl ether) system: we can obtain the complete disappearance of OH groups. The thermomechanical properties of the reaction product considerably change with the temperature, moisture and curing time. 相似文献
104.
Xiao-Nan Zhang Albert T. Lam Qinqin Cheng Valentine V. Courouble Timothy S. Strutzenberg Jiawei Li Yiling Wang Hua Pei Bangyan L. Stiles Stan G. Louie Patrick R. Griffin Yong Zhang 《Chemical science》2022,13(7):1982
Among various protein posttranslational modifiers, poly-ADP-ribose polymerase 1 (PARP1) is a key player for regulating numerous cellular processes and events through enzymatic attachments of target proteins with ADP-ribose units donated by nicotinamide adenine dinucleotide (NAD+). Human PARP1 is involved in the pathogenesis and progression of many diseases. PARP1 inhibitors have received approvals for cancer treatment. Despite these successes, our understanding about PARP1 remains limited, partially due to the presence of various ADP-ribosylation reactions catalyzed by other PARPs and their overlapped cellular functions. Here we report a synthetic NAD+ featuring an adenosyl 3′-azido substitution. Acting as an ADP-ribose donor with high activity and specificity for human PARP1, this compound enables labelling and profiling of possible protein substrates of endogenous PARP1. It provides a unique and valuable tool for studying PARP1 in biology and pathology and may shed light on the development of PARP isoform-specific modulators.An analogue of nicotinamide adenine dinucleotide (NAD+) featuring an azido group at 3′-OH of adenosine moiety is found to possess high specificity for human PARP1-catalyzed protein poly-ADP-ribosylation. 相似文献
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106.
Junyi Gong Peifa Wei Yuanan Su Ying Li Xing Feng Jacky W. Y. Lam Dongzhou Zhang Xiangzhi Song Ben Zhong Tang 《中国化学快报》2018,29(10):1493-1496
Three salicylaldehyde Schiff base (SSB) with AIE behavior were designed and facilely synthesized through a condensation reaction. In solid and aggregation states, these SSB dyes exhibited yellow to red emission with large Stokes shift. One of SSB dyes could specifically stain lipid droplets in living cells. 相似文献
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109.
Adrian K. Y. Lam Craig A. Hutton Richard A. J. O'Hair 《Rapid communications in mass spectrometry : RCM》2010,24(17):2591-2604
A combination of electrospray ionisation (ESI), multistage and high‐resolution mass spectrometry experiments was used to compare the gas‐phase chemistry of the amino acids histidine (1), 2‐oxo‐histidine (2), and 2‐thioxo‐histidine (3). Collision‐induced dissociation (CID) of all three different proton‐bound heterodimers of these amino acids led to the relative gas‐phase proton affinity order of: histidine >2‐thioxo‐histidine >2‐oxo‐histidine. Density functional theory (DFT) calculations confirm this order, with the lower proton affinities of the oxidised histidine derivatives arising from their ability to adopt the more stable keto/thioketo tautomeric forms. All protonated amino acids predominately fragment via the combined loss of H2O and CO to yield a1 ions. Protonated 2 and 3 also undergo other small molecule losses including NH3 and the imine HN=CHCO2H. The observed differences in the fragmentation pathways are rationalised through DFT calculations, which reveal that while modification of histidine via the introduction of the oxygen atom in 2 or the sulfur atom in 3 does not affect the barriers against the loss of H2O+CO, barriers against the losses of NH3 and HN=CHCO2H are lowered relative to protonated histidine. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
110.