The preparation of Calcipotriol by solid lipid nanoparticles and the encapsulation of drugs in solid lipids are expected to obtain a new preparation with strong cutin permeability, slow release and targeting effect, so as to improve the local therapeutic effect of the drug and reduce the occurrence of skin irritation symptoms. In this work, Calcipotriol solid lipid nanoparticle (CPT-SLN) preparation methods are introduced and the stability of CPT-SLNs gel was evaluated by appearance, leakage rate and content. The performance was stable in a low-temperature environment of 4 °C for 40 days. There were no significant changes in appearance, and drug content and permeability can be controlled around 0.00469% and 0.26. However, it has poor stability under the storage conditions of 25 °C and 40 °C at room temperature. Therefore, the suitable conditions for the gel storage should be around 4 °C and sealed away from light. Pharmacodynamic experiments showed that CPT solid lipid nanoparticle gel was more effective than market-sale Calcipotriol ointment in the treatment of psoriasis. Further clinical tests have shown that CPT-SLNS can cure plaque psoriasis more effectively.
Photocatalysis technology has been proved to be a potential strategy for removal of organic dyes, however high-power light sources are generally necessary to initiate photocatalytic reaction. In this work, we employed an excellent photocatalyst of Bi2WO6 with visible light harvest and meanwhile an intrinsic ferroelectricity, which realized the efficient degradation of organic dye via the synergetic photopiezocatalysis. Through coupling the illumination by a low-power (9 W) LED and the ultrasonic vibration (120 W) by an ultrasonic cleaner, the nanoflower-like Bi2WO6 composed of ultrathin nanosheets showed a much more enhanced photopiezocatalysis performance for purification of organic dye than the individual photocatalysis and piezocatalysis. Furthermore, the high mineralization efficiency and the good durability of the Bi2WO6 catalyst were demonstrated. The possible mechanism of photopiezocatalysis was finally proposed, where the ultrasound-induced piezoelectric field in Bi2WO6 drove photo-generated electrons and holes to diffuse along opposite directions, consequently promoting the separation efficiency of charge carriers. This work indicates that the synergetic photopiezocatalysis by coupling irradiation and ultrasonic vibration is a promising strategy to purify organic pollutants in wastewater. 相似文献
We make a mapping from Sierpinski fractals to a new class
of networks, the incompatibility networks, which are scale-free,
small-world, disassortative, and maximal planar graphs. Some
relevant characteristics of the networks such as degree
distribution, clustering coefficient, average path length, and
degree correlations are computed analytically and found to be
peculiarly rich. The method of network representation can be applied
to some real-life systems making it possible to study the complexity
of real networked systems within the framework of complex network
theory. 相似文献
In this paper,the frequency-locking and threshold current-lowering effects of a quantum cascade laser are studied and achieved.Combined with cavity-enhanced absorption spectroscopy,the noninvasive detection of H_2 with a prepared concentration of 500 ppm in multiple dissolved gases is performed and evaluated.The high frequency selectivity of 0.0051 cm~(-1) at an acquisition time of 1 s allows the sensitive detection of the(1-0) S(l) band of H_2 with a high accuracy of(96.53±0.29)%and shows that the detection limit to an absorption line of 4712.9046 cm~(-1) is approximately(17.26±0.63) ppm at an atmospheric pressure and a temperature of 20 ℃. 相似文献