A thermodynamic approach to non-local damage modelling of concrete

This paper focuses on the development of a thermodynamic approach to constitutive modelling of concrete materials, with emphasis on the use of non-local damage models. Effort is put on the construction of a consistent and rigorous thermodynamic framework, which readily allows the incorporation of non-local features into the constitutive modelling. This is an important feature in developing non-local constitutive models based on thermodynamics. Examples of non-local constitutive models derived from this framework and numerical examples are given to demonstrate the promising features of the proposed approach.     

Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Stem cell-based therapies with clinical applications require millions of cells. Therefore, repeated subculture is essential for cellular expansion, which is often complicated by replicative senescence. Cellular senescence contributes to reduced stem cell regenerative potential as it inhibits stem cell proliferation and differentiation as well as the activation of the senescence-associated secretory phenotype (SASP). In this study, we employed MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation. In vitro experiments showed that the MHY-1685‒primed hCSCs exhibited higher viability in response to oxidative stress and an enhanced proliferation potential compared to that of the unprimed senile hCSCs. Interestingly, priming MHY-1685 enhanced the expression of stemness-related markers in senile hCSCs and provided the differentiation potential of hCSCs into vascular lineages. In vivo experiment with echocardiography showed that transplantation of MHY-1685‒primed hCSCs improved cardiac function than that of the unprimed senile hCSCs at 4 weeks post-MI. In addition, hearts transplanted with MHY-1685-primed hCSCs exhibited significantly lower cardiac fibrosis and higher capillary density than that of the unprimed senile hCSCs. In confocal fluorescence imaging, MHY-1685‒primed hCSCs survived for longer durations than that of the unprimed senile hCSCs and had a higher potential to differentiate into endothelial cells (ECs) within the infarcted hearts. These findings suggest that MHY-1685 can rejuvenate senile hCSCs by modulating autophagy and that as a senescence inhibitor, MHY-1685 can provide opportunities to improve hCSC-based myocardial regeneration.Subject terms: Heart stem cells, Stem-cell therapies     

PEGylated poly(amidoamine) dendrimers-based drug loading vehicles for delivering carboplatin in treatment of various cancerous cells

Journal of Nanoparticle Research - Highly ordered TiO2 nanotube arrays (TiO2 NTs) were synthesized by anodization method using a titanium foil and further modified with nanoparticles...     

Some Computational Aspects of Geodesic Convex Sets in a Simple Polygon

In this article, we deal with some computational aspects of geodesic convex sets. Motzkin-type theorem, Radon-type theorem, and Helly-type theorem for geodesic convex sets are shown. In particular, given a finite collection of geodesic convex sets in a simple polygon and an “oracle,” which accepts as input three sets of the collection and which gives as its output an intersection point or reports its nonexistence; we present an algorithm for finding an intersection point of this collection.     

Electric field-induced magnetoresistance in spin-valve/piezoelectric multiferroic laminates for low-power spintronics

Electric field-induced magnetic anisotropy has been realized in the spin-valve-based {Ni₈₀Fe₂₀/Cu/Fe₅₀Co₅₀/IrMn}/piezoelectric multiferroic laminates. In this system, electric-field control of magnetization is accomplished by strain mediated magnetoelectric coupling. Practically, the magnetization in the magnetostrictive FeCo layer of the spin-valve structure rotates under an effective compressive stress caused by the inverse piezoelectric effect in external electrical fields. This phenomenon is evidenced by the magnetization and magnetoresistance changes under the electrical field applied across the piezoelectric layer. The result shows great potential for advanced low-power spintronic devices.     

Higher-order tangent epiderivatives and applications to duality in set-valued optimization

In the paper, we introduce higher-order tangent epiderivatives for set-valued maps. Then, we study some basic properties of these concepts. Finally, we establish some results on duality in set-valued optimization. Several examples are given to illustrate the obtained results.

     

Synthesis of novel chiral monophosphine ligands derived from isomannide and isosorbide. Application to enantioselective hydrogenation of olefins

A new class of monophosphine ligands has been prepared from natural chirality renewable source, 1,4:3,6-dianhydrohexitol compounds, via a nucleophilic substitution process, or a hydrophosphination reaction involving microwave activation. These ligands have been evaluated for the rhodium-catalyzed enantioselective hydrogenation of olefins giving good conversion and enantioselectivity up to 95% and 96% ee, respectively.