全文获取类型
收费全文 | 673篇 |
免费 | 20篇 |
国内免费 | 3篇 |
专业分类
化学 | 512篇 |
晶体学 | 1篇 |
力学 | 17篇 |
数学 | 78篇 |
物理学 | 88篇 |
出版年
2023年 | 7篇 |
2022年 | 19篇 |
2021年 | 15篇 |
2020年 | 11篇 |
2019年 | 7篇 |
2018年 | 10篇 |
2017年 | 5篇 |
2016年 | 19篇 |
2015年 | 20篇 |
2014年 | 17篇 |
2013年 | 30篇 |
2012年 | 40篇 |
2011年 | 34篇 |
2010年 | 27篇 |
2009年 | 25篇 |
2008年 | 44篇 |
2007年 | 29篇 |
2006年 | 38篇 |
2005年 | 33篇 |
2004年 | 29篇 |
2003年 | 24篇 |
2002年 | 25篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 13篇 |
1998年 | 7篇 |
1997年 | 7篇 |
1996年 | 8篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 5篇 |
1991年 | 13篇 |
1990年 | 6篇 |
1988年 | 12篇 |
1987年 | 3篇 |
1986年 | 10篇 |
1985年 | 9篇 |
1984年 | 3篇 |
1983年 | 7篇 |
1982年 | 8篇 |
1981年 | 5篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1941年 | 2篇 |
1937年 | 1篇 |
1934年 | 3篇 |
排序方式: 共有696条查询结果,搜索用时 15 毫秒
51.
Aurora Molinari Alfonso Oliva Marlene Arismendi Elizabeth Imbarack Cristian Glvez Javier Maldonado Arturo San Feliciano 《Journal of heterocyclic chemistry》2015,52(2):620-622
New fused pyrazolo‐1,4‐naphthoquinones were prepared from the reaction of hydrazines with 6‐(4‐methyl‐3‐pentenyl)‐1,4‐naphthoquinone. The reaction was extended to hydroxylamine to afford the corresponding isoxazolo‐1,4‐napthoquinone compound. 相似文献
52.
Accuracy assessment of the linear Poisson–Boltzmann equation and reparametrization of the OBC generalized Born model for nucleic acids and nucleic acid–protein complexes 下载免费PDF全文
Federico Fogolari Alessandra Corazza Gennaro Esposito 《Journal of computational chemistry》2015,36(9):585-596
The generalized Born model in the Onufriev, Bashford, and Case (Onufriev et al., Proteins: Struct Funct Genet 2004, 55, 383) implementation has emerged as one of the best compromises between accuracy and speed of computation. For simulations of nucleic acids, however, a number of issues should be addressed: (1) the generalized Born model is based on a linear model and the linearization of the reference Poisson–Boltmann equation may be questioned for highly charged systems as nucleic acids; (2) although much attention has been given to potentials, solvation forces could be much less sensitive to linearization than the potentials; and (3) the accuracy of the Onufriev–Bashford–Case (OBC) model for nucleic acids depends on fine tuning of parameters. Here, we show that the linearization of the Poisson Boltzmann equation has mild effects on computed forces, and that with optimal choice of the OBC model parameters, solvation forces, essential for molecular dynamics simulations, agree well with those computed using the reference Poisson–Boltzmann model. © 2015 Wiley Periodicals, Inc. 相似文献
53.
Sheng Yao Chun-Ping Tang Yang Ye Tibor Kurtn Attila Kiss-Szikszai Sndor Antus Gennaro Pescitelli Piero Salvadori Karsten Krohn 《Tetrahedron: Asymmetry》2008,19(17):2007-2014
Nine bis-9,10-dihydrophenanthrene and 9,10-dihydrophenanthrene/(dihydro)stilbene derivatives, including the new phochinenins G-L 1–6, were isolated from the whole plant of Pholidota chinensis. Their structures were elucidated on the basis of extensive spectroscopic investigations (1D, 2D NMR, and HR-EIMS). Owing to the sterically hindered rotation around the biaryl axis, some of these biaryl compounds can exist as a pair of enantiomers, but were isolated as racemates. Computed inversion barriers of selected atropisomeric derivatives suggested that phochinenins K 5, gymconpin C 7, and flavanthrin 9 have stable atropisomers. Their racemates were separated by HPLC on an optically active stationary phase, and were stereochemically characterized on-line by circular dichroism (CD) spectroscopy (LC-CD coupling), in conjunction with quantum-mechanics CD calculations. 相似文献
54.
P. Bruno M. Caselli G. de Gennaro P. Ielpo B.E. Daresta P.R. Dambruoso V. Paolillo C.M. Placentino L. Trizio 《Microchemical Journal》2008,88(2):121-129
The human activities in their various aspects cause a change in the natural air quality. This change results more marked in very populated and in high industrialized areas. Some pollutants emitted are typical of a particular activity. Each source of pollution is identified by its profile in the composition of the emissions in the environment. Multivariate receptor models can be used in order to apportion pollutants to the different sources assessing the contribution of each source to the total pollution.This paper deals with the application of Absolute Principal Component Scores (APCS) receptor model to data obtained from the automatic network of air quality monitoring in the city of Bari (South Italy). The parameters monitored by automatic networks, as bihourly values, are PM10, NOx, CO, Benzene, Toluene, Xilene. The data shown in this paper concerning 1 month almost of sampling in different monitoring stations of Bari Municipality during the period of time from January 2005 to April 2006. Moreover preliminary results obtained applying the APCS model to daily PM2.5 samples collected during SITECOS PRIN project are shown. The results concerning data collected in corso Cavour (Bari) during the month of October 2005.The results obtained by APCS receptor model seem to suggest a poor contribution of the “vehicular traffic source” and a relevant contribution of the “secondary particulate source” to particulate matter concentrations. 相似文献
55.
Bottaro M Frascarolo P Gosetti F Mazzucco E Gianotti V Polati S Pollici E Piacentini L Pavese G Gennaro MC 《Journal of the American Society for Mass Spectrometry》2008,19(8):1221-1229
The paper studies, with the help of HPLC-DAD-MS/MS technique, the hydrolytic and photoinduced degradation processes that take place in aqueous solutions of tribenuron methyl, both when preserved in the dark and when undergoing solar box irradiation under conditions that simulate sun light. The results indicate that the degradation products formed by hydrolysis alone and by photoirradiation are the same, but kinetics of the hydrolysis reaction is much slower. The degradation products are identified as 2-methoxy-4-methylamino-6-methyl-1,3,5-triazine (P1), methyl 2-aminosulfonylbenzoate (P2), and saccharin (P3) and quantified. Ecotoxicological biotests performed on 0.1 microg L(-1) photoirradiated solutions of the herbicide give a border line toxicity situation comparable to that of the precursor and indicate that the herbicide is characterized by low persistence in the environment, as required. Its degradation, however, does not lead to mineralization but to the formation of products of comparable toxicity. To evaluate the matrix effects, the photodegradation of the herbicide is also studied in the presence of rice paddy waters: the process is slower than in ultrapure water but leads to the same products. Experiments performed for comparison by irradiating ultrapure water solutions with UV lamp (254 nm) show that the degradation process is not only faster with respect to sunlight, but gives a different pathway, without in anyway leading to mineralization. 相似文献
56.
57.
58.
Dr. Carles Acosta-Silva Prof. Joan Bertran Prof. Vicenç Branchadell Prof. Antoni Oliva 《Chemphyschem》2020,21(22):2594-2604
The effect of solvent reaction fields and oriented electric fields on the Kemp elimination reaction between methylamine or imidazole and 5-nitrobenzisoxazole has been theoretically studied. The Kemp reaction is the most widely used for the design of new enzymes. Our results, using the SMD continuous model for solvents, are in quite good agreement with the experimental fact that the rate of the analogous reaction with butylamine is one order of magnitude smaller in water than in acetonitrile. In the case of external electric fields, our results show that they can increase or decrease the energy barrier depending on the magnitude and orientation of the field. A duly oriented electric field may have a notable catalytic effect on the reaction. So, external electric fields and reaction fields due to the medium can contribute to the design of new enzymes. Several factors that must be taken into account to increase the catalytic effect are discussed. 相似文献
59.
Highly selective enzymatic reductions of aldehydes to the corresponding alcohols was performed using an E. coli JM109 whole cell biocatalyst. A selective enzymatic method for the reduction of aldehydes could provide an eco-compatible alternative to chemical methods. The simplicity, fairly wide scope and the very high observed chemoselectivity of this approach are its most unique features. 相似文献
60.
Oliva MM Casado J Hennrich G López Navarrete JT 《The journal of physical chemistry. B》2006,110(39):19198-19206
The molecular and electronic structures of a series of all-meta-substituted phenylacetylene mesitylenes peripherally substituted with donor or acceptor (D-A) groups are studied. The impact of meta- and para-substitution patterns is also analyzed by employing Raman and optical spectroscopies in conjunction with theoretical calculations. Outer phenyl rings display a partial quinoid character induced by two different motifs: (i) outer phenyls --> triple bond charge transfer for the cases where these phenyls are substituted with electron-donors; (ii) double electron withdrawing effect in the molecules with the peripheral phenyls substituted with electron acceptors. A moderate tuning of the optical gap is observed in agreement with the partial blockade of pi-electron conjugation exerted by the meta disposition. The orbital structure of the compounds partially preserves that of the mesitylene group showing extra-conjugation due to the addition of the arms, so that conjugation is not entirely obstructed but partially impeded in the ground electronic state (i.e., electron occupied orbitals). As for the excited states, the low-lying energy empty orbitals offer better conditions for full conjugation over the whole molecular scaffold. Interesting optical properties such as overlapping centers along the lowest energy optical excitations and enhanced optical transparency with importance for the application of these materials in optoelectronics have been justified on the basis of the electronic structure. A greater degree of quinoidization, and more allowed pi-electron delocalization, over the entire molecule is recognized in the case of linear phenylacetylenes substituting in para positions the central core. 相似文献