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41.
José Ernesto Falcón Dieguez Pablo Rodi Manuel A. Lores Guevara Ana Maria Gennaro 《Applied magnetic resonance》2010,38(4):443-453
An enhanced hemoglobin–membrane association has been previously documented in sickle cell anemia. However, it is not known
how this interaction is modified during the hemoglobin S polymerization process. In this work, we use a model of reconstituted
erythrocytes from ghost membranes whose cytoskeleton proteins had been previously labeled with the 4-maleimido Tempo spin
label, and that were subsequently resealed with hemoglobin S or A solutions. Using electron paramagnetic resonance spectroscopy,
we studied the time dependence of the spectral W/S parameter, indicative of the conformational state of cytoskeleton proteins
(mainly spectrin) under spontaneous deoxygenation, with the aim of detecting the eventual effects due to hemoglobin S polymerization.
The differences observed in the temporal behavior of W/S in erythrocytes reconstituted with both hemoglobins were considered
as experimental evidence of an increment in hemoglobin S–membrane interaction as a result of the polymerization process of
hemoglobin S under spontaneous deoxygenation. 相似文献
42.
In this note we extend the main result in [6] on artinian ideals failing Lefschetz properties, varieties satisfying Laplace equations and existence of suitable singular hypersurfaces. Moreover we characterize the minimal generation of ideals generated by powers of linear forms by the configuration of their dual points in the projective plane and we use this result to improve some propositions on line arrangements and Strong Lefschetz Property at range 2 in [6]. The starting point was an example in [3]. Finally we show the equivalence among failing SLP, Laplace equations and some unexpected curves introduced in [3]. 相似文献
43.
Razvigor Ossikovski Quang Nguyen Gennaro Picardi Joachim Schreiber Pierre Morin 《Journal of Raman spectroscopy : JRS》2008,39(5):661-672
We present the theory underlying the large numerical aperture objective micro‐Raman backscattering experiment and apply it to the elaboration of a characterization methodology for the determination of the stress tensor in strained cubic semiconductor structures. The presented stress characterization technique consists in monitoring the variations of the stress‐sensitive optical phonon peak position and linewidth while rotating stepwise the sample about its normal. The practical application of the technique is illustrated on a silicon‐on‐insulator (SOI) microelectronic structure demonstrating a plane stress‐tensor determination. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
44.
45.
P. Bruno M. Caselli G. de Gennaro P. Ielpo B.E. Daresta P.R. Dambruoso V. Paolillo C.M. Placentino L. Trizio 《Microchemical Journal》2008,88(2):121-129
The human activities in their various aspects cause a change in the natural air quality. This change results more marked in very populated and in high industrialized areas. Some pollutants emitted are typical of a particular activity. Each source of pollution is identified by its profile in the composition of the emissions in the environment. Multivariate receptor models can be used in order to apportion pollutants to the different sources assessing the contribution of each source to the total pollution.This paper deals with the application of Absolute Principal Component Scores (APCS) receptor model to data obtained from the automatic network of air quality monitoring in the city of Bari (South Italy). The parameters monitored by automatic networks, as bihourly values, are PM10, NOx, CO, Benzene, Toluene, Xilene. The data shown in this paper concerning 1 month almost of sampling in different monitoring stations of Bari Municipality during the period of time from January 2005 to April 2006. Moreover preliminary results obtained applying the APCS model to daily PM2.5 samples collected during SITECOS PRIN project are shown. The results concerning data collected in corso Cavour (Bari) during the month of October 2005.The results obtained by APCS receptor model seem to suggest a poor contribution of the “vehicular traffic source” and a relevant contribution of the “secondary particulate source” to particulate matter concentrations. 相似文献
46.
Bottaro M Frascarolo P Gosetti F Mazzucco E Gianotti V Polati S Pollici E Piacentini L Pavese G Gennaro MC 《Journal of the American Society for Mass Spectrometry》2008,19(8):1221-1229
The paper studies, with the help of HPLC-DAD-MS/MS technique, the hydrolytic and photoinduced degradation processes that take place in aqueous solutions of tribenuron methyl, both when preserved in the dark and when undergoing solar box irradiation under conditions that simulate sun light. The results indicate that the degradation products formed by hydrolysis alone and by photoirradiation are the same, but kinetics of the hydrolysis reaction is much slower. The degradation products are identified as 2-methoxy-4-methylamino-6-methyl-1,3,5-triazine (P1), methyl 2-aminosulfonylbenzoate (P2), and saccharin (P3) and quantified. Ecotoxicological biotests performed on 0.1 microg L(-1) photoirradiated solutions of the herbicide give a border line toxicity situation comparable to that of the precursor and indicate that the herbicide is characterized by low persistence in the environment, as required. Its degradation, however, does not lead to mineralization but to the formation of products of comparable toxicity. To evaluate the matrix effects, the photodegradation of the herbicide is also studied in the presence of rice paddy waters: the process is slower than in ultrapure water but leads to the same products. Experiments performed for comparison by irradiating ultrapure water solutions with UV lamp (254 nm) show that the degradation process is not only faster with respect to sunlight, but gives a different pathway, without in anyway leading to mineralization. 相似文献
47.
Baratta W Ballico M Esposito G Rigo P 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(18):5588-5595
The reaction of [RuCl(CNN)(dppb)] (1; HCNN=6-(4-methylphenyl)-2-pyridylmethylamine) with NaOiPr in 2-propanol/C6D6 affords the alcohol adduct alkoxide [Ru(OiPr)(CNN)(dppb)].n iPrOH (5), containing the Ru-NH2 linkage. The alkoxide [Ru(OiPr)(CNN)(dppb)] (4) is formed by treatment of the hydride [Ru(H)(CNN)(dppb)] (2) with acetone in C6D6. Complex 5 in 2-propanol/C6D6 equilibrates quickly with hydride 2 and acetone with an exchange rate of (5.4+/-0.2) s(-1) at 25 degrees C, higher than that found between 4 and 2 ((2.9+/-0.4) s(-1)). This fast process, involving a beta-hydrogen elimination versus ketone insertion into the Ru-H bond, occurs within a hydrogen-bonding network favored by the Ru-NH2 motif. The cationic alcohol complex [Ru(CNN)(dppb)(iPrOH)](BAr(f)4) (6; Ar(f)=3,5-C6H3(CF3)2), obtained from 1, Na[BAr(f)4], and 2-propanol, reacts with NaOiPr to afford 5. Complex 5 reacts with either 4,4'-difluorobenzophenone through hydride 2 or with 4,4'-difluorobenzhydrol through protonation, affording the alkoxide [Ru(OCH(4-C6H4F)2)(CNN)(dppb)] (7) in 90 and 85 % yield of the isolated product. The chiral CNN-ruthenium compound [RuCl(CNN)((S,S)-Skewphos)] (8), obtained by the reaction of [RuCl2(PPh3)3] with (S,S)-Skewphos and orthometalation of HCNN in the presence of NEt3, is a highly active catalyst for the enantioselective transfer hydrogenation of methylaryl ketones (turnover frequencies (TOFs) of up to 1.4 x 10(6) h(-1) at reflux were obtained) with up to 89% ee. Also the ketone CF3CO(4-C6H4F), containing the strong electron-withdrawing CF3 group, is reduced to the R alcohol with 64% ee and a TOF of 1.5 x 10(4) h(-1). The chiral alkoxide [Ru(OiPr)(CNN)((S,S)-Skewphos)]n iPrOH (9), obtained from 8 and NaOiPr in the presence of 2-propanol, reacts with CF3CO(4-C6H4F) to afford a mixture of the diastereomer alkoxides [Ru(OCH(CF3)(4-C6H4F))(CNN)((S,S)-Skewphos)] (10/11; 74% yield) with 67% de. This value is very close to the enantiomeric excess of the alcohol (R)-CF3CH(OH)(4-C6H4F) formed in catalysis, thus suggesting that diastereoisomeric alkoxides with the Ru-NH2 linkage are key species in the catalytic asymmetric transfer hydrogenation reaction. 相似文献
48.
Sheng Yao Chun-Ping Tang Yang Ye Tibor Kurtn Attila Kiss-Szikszai Sndor Antus Gennaro Pescitelli Piero Salvadori Karsten Krohn 《Tetrahedron: Asymmetry》2008,19(17):2007-2014
Nine bis-9,10-dihydrophenanthrene and 9,10-dihydrophenanthrene/(dihydro)stilbene derivatives, including the new phochinenins G-L 1–6, were isolated from the whole plant of Pholidota chinensis. Their structures were elucidated on the basis of extensive spectroscopic investigations (1D, 2D NMR, and HR-EIMS). Owing to the sterically hindered rotation around the biaryl axis, some of these biaryl compounds can exist as a pair of enantiomers, but were isolated as racemates. Computed inversion barriers of selected atropisomeric derivatives suggested that phochinenins K 5, gymconpin C 7, and flavanthrin 9 have stable atropisomers. Their racemates were separated by HPLC on an optically active stationary phase, and were stereochemically characterized on-line by circular dichroism (CD) spectroscopy (LC-CD coupling), in conjunction with quantum-mechanics CD calculations. 相似文献
49.
Here we report a simple and fast method for wine fingerprinting based on direct matrix-assisted laser desorption/ionization
(MALDI) mass spectrometry analysis of different red wine samples, useful for batch-to-batch analysis and for the detection
of key compounds even in trace amounts which may vary from vintage to vintage, and from one treatment to another one. A series
of 20 samples from different wines were subjected to MALDI mass spectrometry. We found that 2,5-dihydroxybenzoic acid is far superior with respect to all the matrices tested To the best of our knowledge this is the
first application of an effective wine profiling not limited to detection of anthocyanins. More than 80 molecular species
were detected. Moreover, qualitative and quantitative differences were observed, owing to the nature and relative abundance
of different chemical compounds among the wines. 相似文献
50.
Let be an integral projective curve. One defines the speciality index e(C) of C as the maximal integer t such that , where ω
C
denotes the dualizing sheaf of . Extending a classical result of Halphen concerning the speciality of a space curve, in the present paper we prove that
if is an integral degree d curve not contained in any surface of degree < s, in any threefold of degree < t, and in any fourfold of degree < u, and if , then Moreover equality holds if and only if C is a complete intersection of hypersurfaces of degrees u, , and . We give also some partial results in the general case , .
相似文献